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Review: could Methotrexate cause Memory loss?





Summary: Memory loss is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Folic acid, and have Rheumatoid arthritis.

We study 129,858 people who have side effects while taking Methotrexate from FDA and social media. Among them, 763 have Memory loss. Find out below who they are, when they have Memory loss and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Memory loss >>>

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (view latest outcomes from 131,201 users)

Memory loss

Memory loss has been reported by people with multiple sclerosis, depression, high blood pressure, pain, high blood cholesterol.(view latest reports from 62,109 patients)

On Dec, 13, 2014: 129,841 people reported to have side effects when taking Methotrexate. Among them, 763 people (0.59%) have Memory Loss.

Trend of Memory loss in Methotrexate reports

Time on Methotrexate when people have Memory loss * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Memory loss32.71%20.56%9.35%6.54%14.95%12.15%3.74%

Gender of people who have Memory loss when taking Methotrexate * :

FemaleMale
Memory loss71.28%28.72%

Age of people who have Memory loss when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Memory loss0.00%1.52%10.66%3.32%5.96%19.81%22.99%35.73%

Severity of Memory loss when taking Methotrexate ** :

leastmoderateseveremost severe
Memory loss21.05%42.11%26.32%10.53%

How people recovered from Memory loss ** :

while on the drugafter off the drugnot yet
Memory loss0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (399 people, 52.29%)
  2. Hypertension (65 people, 8.52%)
  3. Psoriatic arthropathy (52 people, 6.82%)
  4. Osteoporosis (48 people, 6.29%)
  5. Pain (45 people, 5.90%)

Top co-used drugs for these people * :

  1. Folic acid (245 people, 32.11%)
  2. Enbrel (188 people, 24.64%)
  3. Humira (161 people, 21.10%)
  4. Prednisone (148 people, 19.40%)
  5. Remicade (120 people, 15.73%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Memory Loss while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Memory Loss
- support group for people who take Methotrexate
- support group for people who have Memory Loss

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Drugs in real world that are associated with:

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Can you answer these questions (Ask a question):

  • Hlab27 antigen and unexplained scratches caused by accutane
    Guinea pig user of Accutane 1982. Experimental drug (told at that time) when a woman hits menopause we are not sure what will happen. I have hit early menopause 42 to be exact. Conjunctivitis, unexplained swelling in fingers, toes, kness, pseudogout (not normal according to my rheumatologist) unexplained scratches in same location, forearms, lower thigh (by knee) fingers. Scratches always are in a line with a break in the line. When a woman hits menopause hormones cease and when this happens the path that Accutane takes to cease sebaceous gland function, skin proliferation ceases. Therefore, my friends the HLA B27 (abnormal antigen targeted for skin proliferation does not know where to go so it randomly attacks whatever organ it chooses. Accutane if I remember correctly and I do have proof, permanently alters DNA. There is no other way orally ingesting a retinolic acid it could control skin, hormonal cesessation. I have only been diagnosed thus far with psoriatic arthritis with no other explanations for these other symptoms. I wonder why this is and I also wonder why dermatologists refuse to take a biopsy of my skin to rule out cell skin proliferation dysfunction. What will this damaging drug attack next. Do no be fooled by Dr.s who tell you that you took this drug so long ago how could this be. Well folks, it is because it has already changed your DNA to the HLAB27 antigen. My question also is, what was supposed to be where this abnormal DNA antigen is and how come this antigen only shows up at menopause. My disease (autoimmune) is progressive) and has already attacked nervous, muscle, skin, joints etc. Interesting
    Reply
  • My sister has been taking depakote cogentin and geodon and suffers with great memory loss inability to carry on a conversation and drops things all the time is this the effect of these drugs? (1 answer)
    Sister takes over 16 perscriptions but the ones mentioned are severe.. due to being bi-polar, and severe agoraphobia and anxiety with depression..is this now her life? Not being able to fully comprehend or remember anything? Dropping things and falling when under the full impact of this medication? I either need to get some acceptance or find answers to the effects this medicine is causing..afraid to change up her medicines but needless to say I am worried...
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  • What's wrong with me?
    I have always been very impatient about everything. I'm never on time
    I can't get anything accomplished around the house I can't concentrate or focus to get the laundry done or the dishes...I walk in circles most days accomplishing nothing!
    Paperwork really stresses me! Wheat her it be for my kids school or for work (I'm a new realtor)
    I just can't seem to do it and always have to ask for help or have someone do it for me! I get very frustrated easily.
    I tend to rant in about things that have no meaning or importance and dismiss important things or forget them at home (signed contracts, keys...)
    I'm getting worse and my dr has put me in seroquill xr recently and I've been on wellbutrin now for about two months. My depression is somewhat better by I still have NO focus and can't seem to get anything done! Weeks go by and I just don't know what I've done with my time!!!
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  • Does one ever get their memory back after discontinueing the tysabri?
    vesicare 10mg x1 bupropion 150mg x1
    lisinopril 5mg as needed bupropion 300mg x1
    fluoxetine 20mg x1 alprazolam 0.5mg - bedtime
    vigil 250mg x1 melatonin 3mg - bedtime
    aubagio 14mg. x1 diphenhydramine 50mg - bedtime
    carvedilol 6.25mg x1 aspirin 500mg - bedtime
    bupropion 300mg x1
    baclofen 10mg as needed DO I NEED ANYTHING ELSE?
    alprazolam 0.5mg
    benedryl 50mg.
    bupropion 300mg
    Reply
  • Has anybody had multi lobar pneumonia from reaction to methotrexate?
    Bilateral multilobar pneumonia - rheumatologist considers it was caused by a reaction to methotrexate I was taking for ankylosing spondylitis and I was lucky to survive. Anyone have this and later shown to have scarring of the lungs?
    Reply

More questions for: Methotrexate, Memory loss

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  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
    Reply
  • Higher than a kite, and dumber than one of those saying i can no longer remember!
    I told my shrink I didn't want to try anymore antidepressants... that they make me crazy-stupid(pristiq), crazy-nympho(wellbutrin), or crazy-sloth(lexapro). I have complex ptsd, did, and gad. I really don't want to take anything... I just want to work out, eat right, and try to put myself back on track. It seems like every time I try these pills I get pushed off course. Anyways here's my experience with pristiq. Day1) dilation ofpupils was noticed with in a few hours, it started to feel like I was on sshrooms....I'd look in the mirror and feel so much love...just stand there staring. I slept better than I did in months. Day 2) Sadly though, when I woke up I couldn't climax, it was like I was numb. My pupils were still dilated and I still felt an out pouring of love and admiration while looking at myself. I tried hard not to fixate and get ready for work. I noticed that my tummy wasn't bloated anymore, I hadn't felt this much releaf in months. As I took my daily 50mg I reassured myself that it was ok not to climax in favor of all the good things I'm feeling now. Pristiq didn't interfere with my routine other than climaxing. Day 3) I awoke well rested with a happy tummy and it didn't bother me a bit not to climax, I jumped out of bed and started my day with vigor. The moment I took my dose and left the house is the last thing I remember! From what I wrote in my calendar, the notes I took, and my phone history I can piece together the things I did for 7 more days!!! I went to work, but my coworker was on holidays so it was just me alone in the office, I have no family or friends in this country (I moved to get away from a bad situation, hence cptsd) anyways I had no interaction. The only thing that brought me out was probably that I stopped taking the medication on day7 (According to the amount of medication left)....it's taken 14 more days to get out of the pristiq fog. During that time I've experienced nightly vivid dreams/ nightmares, extreme sweating and high body temperature, my stomach discomfort fluctuates but I can control it through diet, I'm able to climax again though it takes time, my pupils returned to normal a few days after I returned to myself...I seem to have memory impairment.
    Reply
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
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  • Epipen and memory loss
    I have been constantly injected with epipen which has caused severe memory loss.
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  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
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  • I have had insomnia off and on all my life until I turned 40 and the I was diagnosed with Psoriatic Arthritis and I was tired all the time and I was sleeping a lot for me and it was good to be able to sleep. The doctor put me on Methotrexate and Enbrel and I could still sleep not as much as before ...
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More related studies for: Methotrexate, Memory loss

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