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Review: could Methotrexate cause Memory loss?

Summary: Memory loss is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Folic acid, and have Rheumatoid arthritis.

We study 129,882 people who have side effects while taking Methotrexate from FDA and social media. Among them, 763 have Memory loss. Find out below who they are, when they have Memory loss and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Memory loss >>>

 

 

 

 

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,233 Methotrexate users)

Memory loss

Memory loss has been reported by people with multiple sclerosis, depression, pain, high blood pressure, high blood cholesterol. (latest reports from 63,324 Memory loss patients)

On Jan, 12, 2015: 129,858 people reported to have side effects when taking Methotrexate. Among them, 763 people (0.59%) have Memory Loss.

Trend of Memory loss in Methotrexate reports

Time on Methotrexate when people have Memory loss * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Memory loss32.71%20.56%9.35%6.54%14.95%12.15%3.74%

Gender of people who have Memory loss when taking Methotrexate * :

FemaleMale
Memory loss71.28%28.72%

Age of people who have Memory loss when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Memory loss0.00%1.52%10.66%3.32%5.96%19.81%22.99%35.73%

Severity of Memory loss when taking Methotrexate ** :

leastmoderateseveremost severe
Memory loss21.05%42.11%26.32%10.53%

How people recovered from Memory loss ** :

while on the drugafter off the drugnot yet
Memory loss0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (399 people, 52.29%)
  2. Hypertension (65 people, 8.52%)
  3. Psoriatic arthropathy (52 people, 6.82%)
  4. Osteoporosis (48 people, 6.29%)
  5. Pain (45 people, 5.90%)

Top co-used drugs for these people * :

  1. Folic acid (245 people, 32.11%)
  2. Enbrel (188 people, 24.64%)
  3. Humira (161 people, 21.10%)
  4. Prednisone (148 people, 19.40%)
  5. Remicade (120 people, 15.73%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Memory Loss while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Memory Loss
- support group for people who take Methotrexate
- support group for people who have Memory Loss

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More questions for: Methotrexate, Memory loss

You may be interested at these reviews (Write a review):

  • Methadone and forgetting basic things.
    I have been in MMT (Methadone Maintenance Treatment) for around 7 1/2 years for chronic pain. I have gotten to where I forget things that I never would or did before and the longer in time the worse it has gotten I am currently looking at some different meds for treatment. The loss of memory is everything from childhood memories to what I did yesterday I may pay something and if I dont write it diwn I will forget it things I have known all my life I have forgotten. I can't say 100% it is from the MMT or not however I will sag I had no such problems before and I am at age 38 so I believe I am much too young to have severe memory loss that I am currently experiencing and whats scary is what if it never comes back and continues to decline?
  • Percocet and memory loss
    A close friend of mine has been using prescription Percocet for 5 to 6 years. Her MD first prescribed the lowest dosage possible to be taken 3 to 4 times daily for pain. I am aware that this medication frequently needs to be increased because it will become less effective. I don't know how many times he has increased the dosage but it has been many times. I believe now she is taking the highest dosage of it up to four to six times daily and six tablets at a time. I have made several attempts to tell her the information I know about Percocet and to have her to ask her MD about her now short and long term memory problems. Her response is to shout at me, telling me she needs that much for pain and to mind my own business when I tell her about the negative side effects I see, especially her daily and hourly memory problems. She has also said she has no reason to speak to her doctor about memory problems. I think that is because she fears he might lower the dosage. My concern about her poor memory only causes her to tell me I am the one with a bad memory, even though the only pain meds I infrequently take are OTC ones. According to my MD, I have been told my memory for my age of 63 is perfectly fine and better than most for my age. Also I take no medications with the side effects that cause memory problems. In addition when my MD prescribes new medication I always read the info that accompanies them, do research online and pay attention to all warnings and side effect info. The few times I have had side effects they have only been GI problems and I have consulted my MD regarding those and work with my MD for an alternative medication. My friend NEVER EVER reads any of the accompanying material that comes with her prescriptions. Also she never looks up her medications online to get additional information, including possible side effects. I worry about her very much and fear she now has an addiction to Percocet. Several years ago she asked her MD for Chantix to stop smoking, never reading the info supplied with the prescription. I urged to read the info and side effects. She declined, telling me she knew what she was doing. After two weeks of using Chantix she had a mental break down and ended up on the psych ward of our local hospital for 3 weeks. That medication was the first that began to cause her to have memory problems. She accepted that fact for about a month then dismissed it claiming her memory problems were over. They weren't because she was still taking Percocet. I understand no one wants to be told by a friend they suspect that person has memory problems, but I haven't done so to be mean or cruel, but only out of great love and concern. At this point with all the Percocet she takes daily she really is at a level to be considered an addict and I fear soon she will convince her MD to increase the dosage because it no longer controls her pain. I've written this review as a cautionary tale to inform others to be vigilant with their family, friends and loved ones as Percocet can and does cause short and long term memory loss. Although all my efforts to assist and speak to my friend have failed, please don't give up on those in your life who you notice are experiencing memory loss signs that take Percocet. If possible speak to them or their MD. Oh, and be prepared to be yelled at that you are the one with memory problems or to be told to mind your own business. And please, please read the information that accompanies all of your medications.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Higher than a kite, and dumber than one of those saying i can no longer remember!
    I told my shrink I didn't want to try anymore antidepressants... that they make me crazy-stupid(pristiq), crazy-nympho(wellbutrin), or crazy-sloth(lexapro). I have complex ptsd, did, and gad. I really don't want to take anything... I just want to work out, eat right, and try to put myself back on track. It seems like every time I try these pills I get pushed off course. Anyways here's my experience with pristiq. Day1) dilation ofpupils was noticed with in a few hours, it started to feel like I was on sshrooms....I'd look in the mirror and feel so much love...just stand there staring. I slept better than I did in months. Day 2) Sadly though, when I woke up I couldn't climax, it was like I was numb. My pupils were still dilated and I still felt an out pouring of love and admiration while looking at myself. I tried hard not to fixate and get ready for work. I noticed that my tummy wasn't bloated anymore, I hadn't felt this much releaf in months. As I took my daily 50mg I reassured myself that it was ok not to climax in favor of all the good things I'm feeling now. Pristiq didn't interfere with my routine other than climaxing. Day 3) I awoke well rested with a happy tummy and it didn't bother me a bit not to climax, I jumped out of bed and started my day with vigor. The moment I took my dose and left the house is the last thing I remember! From what I wrote in my calendar, the notes I took, and my phone history I can piece together the things I did for 7 more days!!! I went to work, but my coworker was on holidays so it was just me alone in the office, I have no family or friends in this country (I moved to get away from a bad situation, hence cptsd) anyways I had no interaction. The only thing that brought me out was probably that I stopped taking the medication on day7 (According to the amount of medication left)....it's taken 14 more days to get out of the pristiq fog. During that time I've experienced nightly vivid dreams/ nightmares, extreme sweating and high body temperature, my stomach discomfort fluctuates but I can control it through diet, I'm able to climax again though it takes time, my pupils returned to normal a few days after I returned to myself...I seem to have memory impairment.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine

More reviews for: Methotrexate, Memory loss

Comments from related studies:

  • From this study (3 months ago):

  • I find I can read something but have a difficult time relating what I have just read to another person. Although I understand what I have read, I just seem to have great difficulty putting it into words to relate

    Reply

  • From this study (13 months ago):

  • Several months after starting xarelto short term memory losses became annoying, just normal things, but seemed more often. Now I have to write everything down and daughter has to go to appts with me because I can't remember what to say or what doctor said to do.
    Have "fainted" 3 times unexpectedly, with no warning at all,and no memory,just what people around me say happened.
    None of this happened until after I was put on xarelto.

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  • From this study (2 years ago):

  • I have moments of confusion and things don't look right. I forget to finish things. I get confused about my whereabouts every once in a while.Small every day tasks I forget how to do. Things I do every day like taking the key out of the ignition.It comes back to me in a few minutes but I feel so stupid while it is happening.

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