Review: could Methotrexate cause Mood Swings?


Summary

Mood swings is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Folic Acid, and have Rheumatoid arthritis . We study 120,782 people who have side effects while taking Methotrexate from FDA and social media. Among them, 112 have Mood swings. Find out below who they are, when they have Mood swings and more.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 129,047 users)

Mood Swings

Mood swings (an extreme or rapid change in mood) has been reported by people with breathing difficulty, rashes, drug ineffective, memory loss, fatigue (latest reports from 23,874 Mood swings patients).

On Jul, 29, 2016

120,782 people reported to have side effects when taking Methotrexate.
Among them, 112 people (0.09%) have Mood Swings


Number of reports submitted per year:

Could Methotrexate cause Mood swings?

Time on Methotrexate when people have Mood Swings *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 50.0 %
  • 6 - 12 months: 12.5 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 12.5 %
  • 5 - 10 years: 12.5 %
  • 10+ years: 12.5 %

Gender of people who have Mood Swings when taking Methotrexate *:

  • female: 72.22 %
  • male: 27.78 %

Age of people who have Mood Swings when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 2.17 %
  • 10-19: 22.83 %
  • 20-29: 5.43 %
  • 30-39: 4.35 %
  • 40-49: 9.78 %
  • 50-59: 23.91 %
  • 60+: 31.52 %

Severity if Mood Swings when taking Methotrexate **:

  • least: 0.0 %
  • moderate: 75 %
  • severe: 25 %
  • most severe: 0.0 %

How people recovered from Mood Swings **:

  • while on drug: 33.33 %
  • after off the drug: 0.0 %
  • not yet: 66.67 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (34 people)
  • Crohn's Disease (7 people)
  • Juvenile Arthritis (6 people)
  • Arthritis (5 people)
  • Anxiety (5 people)

Top co-used drugs for these people *:

  • Folic Acid (27 people)
  • Humira (26 people)
  • Enbrel (22 people)
  • Prednisone (13 people)
  • Remicade (10 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Mood swings when taking Methotrexate?

Browse all side effects of Methotrexate

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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