Review: could Methotrexate cause Mood Swings?


Mood swings is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 5 - 10 years, also take medication Folic Acid, and have Rheumatoid arthritis . We study 150,778 people who have side effects while taking Methotrexate from FDA and social media. Among them, 138 have Mood swings. Find out below who they are, when they have Mood swings and more.

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Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 160,929 users)

Mood Swings

Mood swings (an extreme or rapid change in mood) has been reported by people with suicidal ideation, rashes, drug ineffective, fatigue, pain (latest reports from 28,902 Mood swings patients).

On Aug, 26, 2016

150,778 people reported to have side effects when taking Methotrexate.
Among them, 138 people (0.09%) have Mood Swings

Number of reports submitted per year:

Could Methotrexate cause Mood swings?

Time on Methotrexate when people have Mood Swings *:

  • < 1 month: 16.67 %
  • 1 - 6 months: 25.0 %
  • 6 - 12 months: 8.33 %
  • 1 - 2 years: 8.33 %
  • 2 - 5 years: 8.33 %
  • 5 - 10 years: 25.0 %
  • 10+ years: 8.33 %

Gender of people who have Mood Swings when taking Methotrexate *:

  • female: 73.68 %
  • male: 26.32 %

Age of people who have Mood Swings when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 3.74 %
  • 10-19: 14.02 %
  • 20-29: 7.48 %
  • 30-39: 5.61 %
  • 40-49: 15.89 %
  • 50-59: 26.17 %
  • 60+: 27.1 %

Severity if Mood Swings when taking Methotrexate **:

  • least: 0.0 %
  • moderate: 75 %
  • severe: 25 %
  • most severe: 0.0 %

How people recovered from Mood Swings **:

  • while on drug: 33.33 %
  • after off the drug: 0.0 %
  • not yet: 66.67 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (57 people)
  • Hypertension (11 people)
  • Sleep Disorder (9 people)
  • Crohn's Disease (9 people)
  • Depression (7 people)

Top co-used drugs for these people *:

  • Folic Acid (44 people)
  • Humira (36 people)
  • Enbrel (33 people)
  • Prednisone (23 people)
  • Remicade (15 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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