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Review: could Methotrexate cause Mood swings?

Summary: Mood swings is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Folic acid, and have Rheumatoid arthritis.

We study 129,897 people who have side effects while taking Methotrexate from FDA and social media. Among them, 112 have Mood swings. Find out below who they are, when they have Mood swings and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Mood swings >>>

 

 

 

 

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,243 Methotrexate users)

Mood swings

Mood swings (an extreme or rapid change in mood) has been reported by people with quit smoking, depression, birth control, attention deficit hyperactivity disorder, stress and anxiety. (latest reports from 24,771 Mood swings patients)

On Feb, 12, 2015: 129,882 people reported to have side effects when taking Methotrexate. Among them, 112 people (0.09%) have Mood Swings.

Trend of Mood swings in Methotrexate reports

Time on Methotrexate when people have Mood swings * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Mood swings0.00%55.56%0.00%11.11%11.11%11.11%11.11%

Gender of people who have Mood swings when taking Methotrexate * :

FemaleMale
Mood swings69.84%30.16%

Age of people who have Mood swings when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Mood swings0.00%4.59%20.18%5.50%4.59%9.17%23.85%32.11%

Severity of Mood swings when taking Methotrexate ** :

leastmoderateseveremost severe
Mood swings0.00%80.00%20.00%0.00%

How people recovered from Mood swings ** :

while on the drugafter off the drugnot yet
Mood swings50.00%0.00%50.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (44 people, 39.29%)
  2. Crohn's disease (11 people, 9.82%)
  3. Anxiety (9 people, 8.04%)
  4. Pain (8 people, 7.14%)
  5. Arthritis (8 people, 7.14%)

Top co-used drugs for these people * :

  1. Folic acid (45 people, 40.18%)
  2. Humira (38 people, 33.93%)
  3. Enbrel (24 people, 21.43%)
  4. Prednisone (17 people, 15.18%)
  5. Methotrexate sodium (15 people, 13.39%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of methotrexate and mood swings on

Do you have Mood Swings while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Mood Swings
- support group for people who take Methotrexate
- support group for people who have Mood Swings

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Could your condition cause:

Can you answer these questions (Ask a question):

  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
  • Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
    I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?
  • What does unmasking mean; and does it mean that i always had hight cholesterol and triglycerides, or did actemra increase them?
    I have failed many RA meds, and now receive actemera x's 10 months I have never had high cholesterol or triglycerides and did not get my cholesterol checked except for the baseline 2/2014 and 12/2014 I was 198 TChol and now am 245; my tri up 85 points. my MD said that now that my inflammation is normal it shows my true cholestorol. I don't understand.
  • Is it safe to take zocalo if you are taking humora and methotrexate
    Is it safe to take all three of these together? I need to know if there is any adverse side effects of taking these drugs at the same time?

More questions for: Methotrexate, Mood swings

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    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

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    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
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  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
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More reviews for: Methotrexate, Mood swings

Comments from related studies:

  • From this study (3 years ago):

  • Heidi on Jun, 17, 2012:

    I was on Methotrexate injections for a year & then went off of it for about five months. I've been back on it now for 3 weeks now. My family & friends have all noticed (as well as myself) that I have been irritable, moody, mean & edgy since restarting my Methotrexate treatment. I also am always tired while I am taking the drug. I feel as though I can't get enough sleep to feel refreshed & rested. The mood swings are really getting to me. I am actually contemplating stopping the medication for good due to the mood swings it is causing me. I am even on Prozac for depression/anxiety. I can't imagine how bad I would feel if I weren't taking that as well.

    Reply

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