Review: could Methotrexate cause Mood swings?
Summary: Mood swings could be caused by Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take Folic acid, and have Rheumatoid arthritis.
We study 129,658 people who have side effects while taking Methotrexate from FDA and social media. Among them, 109 have Mood swings. Find out below who they are, when they have Mood swings and more.
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Methotrexate (latest outcomes from 130,985 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.
Mood swings (an extreme or rapid change in mood) (latest reports from 119,696 patients) has been reported by people with quit smoking, depression, birth control, attention deficit hyperactivity disorder, pain.
On Apr, 9, 2014: 129,615 people reported to have side effects when taking Methotrexate. Among them, 109 people (0.08%) have Mood Swings. They amount to 0.09% of all the 119,362 people who have Mood Swings on eHealthMe.
Time on Methotrexate when people have Mood swings * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
|Mood swings||0.00%||66.67%||0.00%||16.67%||0.00%||16.67%||0.00% |
Gender of people who have Mood swings when taking Methotrexate * :
|Mood swings||69.11%||30.89% |
Age of people who have Mood swings when taking Methotrexate * :
|Mood swings||0.00%||4.72%||19.81%||5.66%||4.72%||7.55%||24.53%||33.02% |
Severity of Mood swings when taking Methotrexate ** :
|least||moderate||severe||most severe |
|Mood swings||0.00%||50.00%||50.00%||0.00% |
How people recovered from Mood swings ** :
Top conditions involved for these people * :
- Rheumatoid arthritis (43 people, 39.45%)
- Crohn's disease (11 people, 10.09%)
- Anxiety (9 people, 8.26%)
- Arthritis (8 people, 7.34%)
- Blood cholesterol (8 people, 7.34%)
Top co-used drugs for these people * :
- Folic acid (44 people, 40.37%)
- Humira (37 people, 33.94%)
- Enbrel (23 people, 21.10%)
- Prednisone (16 people, 14.68%)
- Methotrexate sodium (15 people, 13.76%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Related topic: Methotrexate, Mood swings
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On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.
What is Methotrexate used for and how effective is it:
Other drugs that are used to treat the same conditions:
Could it be a symptom from a condition:
Drugs in real world that are associated with:
Could your condition cause it?
Comments from related studies:
From this study (2 years ago):
Heidi on Jun, 17, 2012:
I was on Methotrexate injections for a year & then went off of it for about five months. I've been back on it now for 3 weeks now. My family & friends have all noticed (as well as myself) that I have been irritable, moody, mean & edgy since restarting my Methotrexate treatment. I also am always tired while I am taking the drug. I feel as though I can't get enough sleep to feel refreshed & rested. The mood swings are really getting to me. I am actually contemplating stopping the medication for good due to the mood swings it is causing me. I am even on Prozac for depression/anxiety. I can't imagine how bad I would feel if I weren't taking that as well.
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