Review: could Methotrexate cause Premature Menopause?


Premature menopause is found among people who take Methotrexate, especially for people who are 30-39 old also take medication Deflazacort, and have Rheumatoid arthritis . We study 191,459 people who have side effects while taking Methotrexate from FDA and social media. Among them, 14 have Premature menopause. Find out below who they are, when they have Premature menopause and more.

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Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,455 users)

Premature Menopause

Premature menopause has been reported by people with birth control, depression, metastatic malignant melanoma, multiple sclerosis, malignant melanoma (latest reports from 779 Premature menopause patients).

On Sep, 21, 2016

191,459 people reported to have side effects when taking Methotrexate.
Among them, 14 people (0.01%) have Premature Menopause

Number of reports submitted per year:

Could Methotrexate cause Premature menopause?

Age of people who have Premature Menopause when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 16.67 %
  • 20-29: 8.33 %
  • 30-39: 41.67 %
  • 40-49: 33.33 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (9 people, 64.29%)
  • Nausea (4 people, 28.57%)
  • Bone Sarcoma (4 people, 28.57%)
  • Prophylaxis (2 people, 14.29%)
  • Gestational Trophoblastic Tumour (1 person, 7.14%)

Top co-used drugs for these people *:

  • Rituximab (5 people, 35.71%)
  • Pyridoxine Hcl (5 people, 35.71%)
  • Nimesulide (5 people, 35.71%)
  • Dramin (5 people, 35.71%)
  • Deflazacort (5 people, 35.71%)

Top other side effects for these people *:

  • Weight Increased (5 people, 35.71%)
  • Skin Lesion (5 people, 35.71%)
  • Pruritus (5 people, 35.71%)
  • Hypothyroidism (5 people, 35.71%)
  • Erythema (5 people, 35.71%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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