Methotrexate and Premature menopause - from FDA reports


Premature menopause is found among people who take Methotrexate, especially for people who are 30-39 old also take medication Pyridoxine Hcl, and have Rheumatoid arthritis . We study 209,150 people who have side effects while taking Methotrexate from FDA. Among them, 14 have Premature menopause. Find out below who they are, when they have Premature menopause and more.

What to expect?

If you take Methotrexate and have Premature menopause, find out what symptoms you could have in 1 year or longer.

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Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,560 users)

Premature Menopause

Premature menopause has been reported by people with birth control, depression, multiple sclerosis, metastatic malignant melanoma, malignant melanoma (latest reports from 780 Premature menopause patients).

On Feb, 16, 2017

209,150 people reported to have side effects when taking Methotrexate.
Among them, 14 people (0.01%) have Premature Menopause

Number of reports submitted per year:

Could Methotrexate cause Premature menopause?

Age of people who have Premature Menopause when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 16.67 %
  • 20-29: 8.33 %
  • 30-39: 41.67 %
  • 40-49: 33.33 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (9 people, 64.29%)
  • Nausea (4 people, 28.57%)
  • Bone Sarcoma (4 people, 28.57%)
  • Preventive Health Care (2 people, 14.29%)
  • Gestational Trophoblastic Tumor (1 person, 7.14%)

Top co-used drugs for these people *:

  • Pyridoxine Hcl (5 people, 35.71%)
  • Ifosfamide (4 people, 28.57%)
  • Cisplatin (4 people, 28.57%)
  • Etoposide (3 people, 21.43%)
  • Arava (3 people, 21.43%)

Top other side effects for these people *:

  • Rashes (6 people, 42.86%)
  • Weight Increased (5 people, 35.71%)
  • Itching (5 people, 35.71%)
  • Hypothyroidism (5 people, 35.71%)
  • Hypersensitivity (4 people, 28.57%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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