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Review: could Methotrexate cause Premature menopause?

Summary: Premature menopause is found among people who take Methotrexate, especially for people who are female, 30-39 old, also take medication Pyridoxine hcl, and have Rheumatoid arthritis.

We study 129,908 people who have side effects while taking Methotrexate from FDA and social media. Among them, 11 have Premature menopause. Find out below who they are, when they have Premature menopause and more.

You are not alone: join a support group for people who take Methotrexate and have Premature menopause >>>



Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,250 Methotrexate users)

Premature menopause

Premature menopause has been reported by people with birth control, depression, malignant melanoma, multiple sclerosis, rheumatoid arthritis. (latest reports from 558 Premature menopause patients)

On Mar, 29, 2015: 129,908 people reported to have side effects when taking Methotrexate. Among them, 11 people (0.01%) have Premature Menopause.

Trend of Premature menopause in Methotrexate reports

Time on Methotrexate when people have Premature menopause * :


Gender of people who have Premature menopause when taking Methotrexate * :

Premature menopause100.00%0.00%

Age of people who have Premature menopause when taking Methotrexate * :

Premature menopause0.00%0.00%18.18%9.09%45.45%27.27%0.00%0.00%

Severity of Premature menopause when taking Methotrexate ** :


How people recovered from Premature menopause ** :


Top conditions involved for these people * :

  1. Rheumatoid arthritis (8 people, 72.73%)
  2. Nausea (4 people, 36.36%)
  3. Bone sarcoma (3 people, 27.27%)
  4. Prophylaxis (2 people, 18.18%)

Top co-used drugs for these people * :

  1. Pyridoxine hcl (5 people, 45.45%)
  2. Rituximab (5 people, 45.45%)
  3. Dramin (5 people, 45.45%)
  4. Nimesulide (5 people, 45.45%)
  5. Deflazacort (5 people, 45.45%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Premature Menopause while taking Methotrexate?




You are not alone! Join a mobile support group on :
- support group for people who take Methotrexate and have Premature Menopause
- support group for people who take Methotrexate
- support group for people who have Premature Menopause

Drugs in real world that are associated with:

Could your condition cause:

Recent related drug studies (Check your drugs):

Recent Methotrexate related drug comparison:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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