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Review: could Methotrexate cause Premature menopause?

We study 129,746 people who have side effects while taking Methotrexate from FDA and social media. Among them, 11 have Premature menopause. Find out below who they are, when they have Premature menopause and more.

Stay connected: get help anytime and anywhere for people who take Methotrexate and have Premature menopause >>>


Methotrexate (latest outcomes from 131,079 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

Premature menopause

Premature menopause (latest reports from 1,526 patients) has been reported by people with birth control, depression, malignant melanoma, multiple sclerosis, rheumatoid arthritis.

On Jul, 16, 2014: 129,740 people reported to have side effects when taking Methotrexate. Among them, 11 people (0.01%) have Premature Menopause. They amount to 0.72% of all the 1,523 people who have Premature Menopause on eHealthMe.

Trend of Premature menopause in Methotrexate reports

Time on Methotrexate when people have Premature menopause * :


Gender of people who have Premature menopause when taking Methotrexate * :

Premature menopause100.00%0.00%

Age of people who have Premature menopause when taking Methotrexate * :

Premature menopause0.00%0.00%18.18%9.09%45.45%27.27%0.00%0.00%

Severity of Premature menopause when taking Methotrexate ** :


How people recovered from Premature menopause ** :


Top conditions involved for these people * :

  1. Rheumatoid arthritis (8 people, 72.73%)
  2. Nausea (4 people, 36.36%)
  3. Bone sarcoma (3 people, 27.27%)
  4. Prophylaxis (2 people, 18.18%)

Top co-used drugs for these people * :

  1. Pyridoxine hcl (5 people, 45.45%)
  2. Rituximab (5 people, 45.45%)
  3. Dramin (5 people, 45.45%)
  4. Nimesulide (5 people, 45.45%)
  5. Deflazacort (5 people, 45.45%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

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  • Manda1074 on Jun, 19, 2014:

    This is crazy! I was perfectly fertile and doing great until I got the dep shot. Immediately bloated up like 6 ms pregnant after just even a glass of water much more a meal! Gained over 50 lbs in 7 ms! Now I have been off the shot for 4 ms and they told me the reason I am almost bedridden miserable with SEVERE fatigue is because I am somehow POST menopausal???? Why the heck didn the Dr warn me of this with the other symptoms??? Ugh!!! Any suggestions? I cant lose weight.... bloated badly after any and everything and soooo tired bc body isnt digesting food bc of the bloating!


    lisa on Jul, 6, 2012:

    I am going the through the same problem, night sweats,mood swings two stone in weight gain. I came off the depo over 18 months ago and still no period. I have just had my hormone levels done and i am extremley low and just been told i am premenopausal at 32 years old!! i am really unhappy and wish this had been made clear to me from the start. I am now trying to boost my levels with herbal remedies ad high estroegen foods in the hope it will restore my fertility.


    Cynthia on Mar, 29, 2013:

    i was told that the depo sent me into an induced menopause! UGH! I was like what the hell is that... i mean it has been crazy!! I am on my 3rd depo shot as of feb 2013 and just waiting for this shot to leave my system. I just want these symptoms to leave... nausea, hot flashes, not able to sleep (keep waking up), constipated, and bloating,,, ugh... The depo is nothing to play with. I am done! If ya need to talk to me my email is

    I was wondering what everyone is doing for their symptoms?


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On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Methotrexate used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

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