Methotrexate and Premature menopause - from FDA reports


Summary

Premature menopause is found among people who take Methotrexate, especially for people who are 40-49 old , have been taking the drug for 6 - 12 months, also take medication Pyridoxine Hcl, and have Nausea. This review analyzes which people have Premature menopause with Methotrexate. It is created by eHealthMe based on reports of 231,270 people who have side effects when taking Methotrexate from FDA , and is updated regularly.

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On Oct, 23, 2017

231,270 people reported to have side effects when taking Methotrexate.
Among them, 25 people (0.01%) have Premature menopause


Number of reports submitted per year:

Could Methotrexate cause Premature menopause?

Time on Methotrexate when people have Premature menopause *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 100 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Age of people who have Premature menopause when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 15.79 %
  • 20-29: 5.26 %
  • 30-39: 26.32 %
  • 40-49: 52.63 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Top conditions involved for these people *:

  • Nausea (5 people, 20.00%)
  • Bone Sarcoma (4 people, 16.00%)
  • Preventive Health Care (3 people, 12.00%)
  • Gestational Trophoblastic Tumor (2 people, 8.00%)
  • Ovarian Failure (1 person, 4.00%)

Top co-used drugs for these people *:

  • Pyridoxine Hcl (5 people, 20.00%)
  • Ifosfamide (4 people, 16.00%)
  • Cisplatin (4 people, 16.00%)
  • Prednisolone (3 people, 12.00%)
  • Dactinomycin (3 people, 12.00%)

Top other side effects for these people *:

  • Rashes (7 people, 28.00%)
  • Weight Increased (6 people, 24.00%)
  • Itching (5 people, 20.00%)
  • Hypothyroidism (5 people, 20.00%)
  • Amenorrhea (4 people, 16.00%)

* Approximation only. Some reports may have incomplete information.

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Premature menopause and drugs with ingredients of methotrexate sodium.

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Premature menopause and Methotrexate from FDA and eHealthMe reports

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 234,878 users)

Premature menopause

Premature menopause has been reported by people with birth control, depression, multiple sclerosis, metastatic malignant melanoma, malignant melanoma (latest reports from 841 Premature menopause patients).

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