Review: could Methotrexate cause Progressive Multifocal Leukoencephalopathy?


Summary

Progressive multifocal leukoencephalopathy is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 5 - 10 years, also take medication Prednisone, and have Rheumatoid arthritis . We study 150,777 people who have side effects while taking Methotrexate from FDA and social media. Among them, 274 have Progressive multifocal leukoencephalopathy. Find out below who they are, when they have Progressive multifocal leukoencephalopathy and more.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 152,717 users)

Progressive Multifocal Leukoencephalopathy

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells) has been reported by people with apraxia, agitation, confusional state, jc virus infection, monoparesis (latest reports from 5,752 Progressive multifocal leukoencephalopathy patients).

On Aug, 24, 2016

150,777 people reported to have side effects when taking Methotrexate.
Among them, 274 people (0.18%) have Progressive Multifocal Leukoencephalopathy


Number of reports submitted per year:

Could Methotrexate cause Progressive multifocal leukoencephalopathy?

Time on Methotrexate when people have Progressive Multifocal Leukoencephalopathy *:

  • < 1 month: 7.69 %
  • 1 - 6 months: 28.21 %
  • 6 - 12 months: 20.51 %
  • 1 - 2 years: 2.56 %
  • 2 - 5 years: 7.69 %
  • 5 - 10 years: 30.77 %
  • 10+ years: 2.56 %

Gender of people who have Progressive Multifocal Leukoencephalopathy when taking Methotrexate *:

  • female: 67.28 %
  • male: 32.72 %

Age of people who have Progressive Multifocal Leukoencephalopathy when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.83 %
  • 10-19: 7.08 %
  • 20-29: 2.92 %
  • 30-39: 5.0 %
  • 40-49: 17.92 %
  • 50-59: 24.17 %
  • 60+: 42.08 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (123 people)
  • Tonsil Cancer (19 people)
  • Systemic Lupus Erythematosus (15 people)
  • Polymyositis (15 people)
  • Dermatomyositis (13 people)

Top co-used drugs for these people *:

  • Prednisone (60 people)
  • Mabthera (58 people)
  • Rituximab (56 people)
  • Folic Acid (51 people)
  • Cyclophosphamide (45 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Progressive multifocal leukoencephalopathy when taking Methotrexate?

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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