Methotrexate and Progressive multifocal leukoencephalopathy - from FDA reports


Summary

Progressive multifocal leukoencephalopathy is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 5 - 10 years, also take medication Prednisone, and have Rheumatoid arthritis. This review analyzes which people have Progressive multifocal leukoencephalopathy with Methotrexate. It is created by eHealthMe based on reports of 223,372 people who have side effects when taking Methotrexate from FDA, and is updated regularly.

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On May, 01, 2017

223,372 people reported to have side effects when taking Methotrexate.
Among them, 340 people (0.15%) have Progressive Multifocal Leukoencephalopathy


Number of reports submitted per year:

Could Methotrexate cause Progressive multifocal leukoencephalopathy?

Time on Methotrexate when people have Progressive Multifocal Leukoencephalopathy *:

  • < 1 month: 9.43 %
  • 1 - 6 months: 26.42 %
  • 6 - 12 months: 18.87 %
  • 1 - 2 years: 1.89 %
  • 2 - 5 years: 9.43 %
  • 5 - 10 years: 30.19 %
  • 10+ years: 3.77 %

Gender of people who have Progressive Multifocal Leukoencephalopathy when taking Methotrexate *:

  • female: 65.66 %
  • male: 34.34 %

Age of people who have Progressive Multifocal Leukoencephalopathy when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.68 %
  • 10-19: 6.76 %
  • 20-29: 2.36 %
  • 30-39: 6.42 %
  • 40-49: 17.91 %
  • 50-59: 21.96 %
  • 60+: 43.92 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (145 people, 42.65%)
  • Tonsil Cancer (22 people, 6.47%)
  • Systemic Lupus Erythematosus (21 people, 6.18%)
  • Polymyositis (15 people, 4.41%)
  • Acute Lymphocytic Leukemia (all) (14 people, 4.12%)

Top co-used drugs for these people *:

  • Prednisone (62 people, 18.24%)
  • Folic Acid (53 people, 15.59%)
  • Cyclophosphamide (50 people, 14.71%)
  • Rituxan (43 people, 12.65%)
  • Prednisolone (42 people, 12.35%)

Top other side effects for these people *:

  • Jc Virus Infection (38 people, 11.18%)
  • Speech Impairment (adult) (32 people, 9.41%)
  • Pneumonia (23 people, 6.76%)
  • Weakness (19 people, 5.59%)
  • Lymphopenia (18 people, 5.29%)

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Progressive multifocal leukoencephalopathy when taking Methotrexate?

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 226,881 users)

Progressive Multifocal Leukoencephalopathy

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells) has been reported by people with multiple sclerosis, relapsing-remitting multiple sclerosis, chronic lymphocytic leukaemia, non-hodgkin's lymphoma, rheumatoid arthritis (latest reports from 7,639 Progressive multifocal leukoencephalopathy patients).

Browse all side effects of Methotrexate

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Progressive multifocal leukoencephalopathy

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Progressive multifocal leukoencephalopathy

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What would happen?

Forecast new side effects and undetected conditions when you take Methotrexate and have Progressive multifocal leukoencephalopathy.

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