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Review: could Methotrexate cause Progressive multifocal leukoencephalopathy?

Summary: Progressive multifocal leukoencephalopathy is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Prednisone, and have Rheumatoid arthritis.

We study 129,925 people who have side effects while taking Methotrexate from FDA and social media. Among them, 246 have Progressive multifocal leukoencephalopathy. Find out below who they are, when they have Progressive multifocal leukoencephalopathy and more.

You are not alone: join a support group for people who take Methotrexate and have Progressive multifocal leukoencephalopathy >>>

 

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,268 Methotrexate users)

Progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells) has been reported by people with multiple sclerosis, relapsing-remitting multiple sclerosis, chronic lymphocytic leukaemia, rheumatoid arthritis, non-hodgkin's lymphoma. (latest reports from 5,167 Progressive multifocal leukoencephalopathy patients)

On Apr, 4, 2015: 129,908 people reported to have side effects when taking Methotrexate. Among them, 246 people (0.19%) have Progressive Multifocal Leukoencephalopathy.

Trend of Progressive multifocal leukoencephalopathy in Methotrexate reports

Time on Methotrexate when people have Progressive multifocal leukoencephalopathy * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Progressive multifocal leukoencephalopathy3.03%36.36%21.21%0.00%6.06%27.27%6.06%

Gender of people who have Progressive multifocal leukoencephalopathy when taking Methotrexate * :

FemaleMale
Progressive multifocal leukoencephalopathy64.86%35.14%

Age of people who have Progressive multifocal leukoencephalopathy when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Progressive multifocal leukoencephalopathy0.00%0.41%7.85%4.13%3.31%16.94%24.38%42.98%

Severity of Progressive multifocal leukoencephalopathy when taking Methotrexate ** :

n/a

How people recovered from Progressive multifocal leukoencephalopathy ** :

n/a

Top conditions involved for these people * :

  1. Rheumatoid arthritis (123 people, 50.00%)
  2. Tonsil cancer (21 people, 8.54%)
  3. Systemic lupus erythematosus (14 people, 5.69%)
  4. Polymyositis (12 people, 4.88%)
  5. Dermatomyositis (11 people, 4.47%)

Top co-used drugs for these people * :

  1. Prednisone (58 people, 23.58%)
  2. Folic acid (56 people, 22.76%)
  3. Mabthera (51 people, 20.73%)
  4. Rituximab (48 people, 19.51%)
  5. Rituxan (45 people, 18.29%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of methotrexate and progressive multifocal leukoencephalopathy on

Do you have Progressive Multifocal Leukoencephalopathy while taking Methotrexate?

 

 

 

You are not alone! Join a support group on :
- support group for people who take Methotrexate and have Progressive Multifocal Leukoencephalopathy
- support group for people who take Methotrexate
- support group for people who have Progressive Multifocal Leukoencephalopathy

Drugs in real world that are associated with:

Could your condition cause:

Recent related drug studies (Check your drugs):

Recent Methotrexate related drug comparison:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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