Review: could Methotrexate cause Progressive multifocal leukoencephalopathy?
Summary: Progressive multifocal leukoencephalopathy is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Prednisone, and have Rheumatoid arthritis.
We study 129,858 people who have side effects while taking Methotrexate from FDA and social media. Among them, 246 have Progressive multifocal leukoencephalopathy. Find out below who they are, when they have Progressive multifocal leukoencephalopathy and more.
You are not alone: join a mobile support group for people who take Methotrexate and have Progressive multifocal leukoencephalopathy >>>
Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 131,201 users)
Progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells) has been reported by people with multiple sclerosis, relapsing-remitting multiple sclerosis, chronic lymphocytic leukaemia, non-hodgkin's lymphoma, rheumatoid arthritis.(latest reports from Progressive multifocal leukoencephalopathy 5,165 patients)
On Nov, 30, 2014: 129,841 people reported to have side effects when taking Methotrexate. Among them, 246 people (0.19%) have Progressive Multifocal Leukoencephalopathy.
Time on Methotrexate when people have Progressive multifocal leukoencephalopathy * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
|Progressive multifocal leukoencephalopathy||3.03%||36.36%||21.21%||0.00%||6.06%||27.27%||6.06% |
Gender of people who have Progressive multifocal leukoencephalopathy when taking Methotrexate * :
|Progressive multifocal leukoencephalopathy||64.86%||35.14% |
Age of people who have Progressive multifocal leukoencephalopathy when taking Methotrexate * :
|Progressive multifocal leukoencephalopathy||0.00%||0.41%||7.85%||4.13%||3.31%||16.94%||24.38%||42.98% |
Severity of Progressive multifocal leukoencephalopathy when taking Methotrexate ** :
How people recovered from Progressive multifocal leukoencephalopathy ** :
Top conditions involved for these people * :
- Rheumatoid arthritis (123 people, 50.00%)
- Tonsil cancer (21 people, 8.54%)
- Systemic lupus erythematosus (14 people, 5.69%)
- Polymyositis (12 people, 4.88%)
- Dermatomyositis (11 people, 4.47%)
Top co-used drugs for these people * :
- Prednisone (58 people, 23.58%)
- Folic acid (56 people, 22.76%)
- Mabthera (51 people, 20.73%)
- Rituximab (48 people, 19.51%)
- Rituxan (45 people, 18.29%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Do you have Progressive Multifocal Leukoencephalopathy while taking Methotrexate?
You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Progressive Multifocal Leukoencephalopathy
- support group for people who take Methotrexate
- support group for people who have Progressive Multifocal Leukoencephalopathy
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Drugs in real world that are associated with:
Could your condition cause:
Can you answer these questions (Ask a question):
- Hlab27 antigen and unexplained scratches caused by accutane
Guinea pig user of Accutane 1982. Experimental drug (told at that time) when a woman hits menopause we are not sure what will happen. I have hit early menopause 42 to be exact. Conjunctivitis, unexplained swelling in fingers, toes, kness, pseudogout (not normal according to my rheumatologist) unexplained scratches in same location, forearms, lower thigh (by knee) fingers. Scratches always are in a line with a break in the line. When a woman hits menopause hormones cease and when this happens the path that Accutane takes to cease sebaceous gland function, skin proliferation ceases. Therefore, my friends the HLA B27 (abnormal antigen targeted for skin proliferation does not know where to go so it randomly attacks whatever organ it chooses. Accutane if I remember correctly and I do have proof, permanently alters DNA. There is no other way orally ingesting a retinolic acid it could control skin, hormonal cesessation. I have only been diagnosed thus far with psoriatic arthritis with no other explanations for these other symptoms. I wonder why this is and I also wonder why dermatologists refuse to take a biopsy of my skin to rule out cell skin proliferation dysfunction. What will this damaging drug attack next. Do no be fooled by Dr.s who tell you that you took this drug so long ago how could this be. Well folks, it is because it has already changed your DNA to the HLAB27 antigen. My question also is, what was supposed to be where this abnormal DNA antigen is and how come this antigen only shows up at menopause. My disease (autoimmune) is progressive) and has already attacked nervous, muscle, skin, joints etc. Interesting
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- I am a 56 year old female with rheumatoid arthritis. i also have found out i have osteoporosis. i keep getting right breast sensitivity also tingling and tenderness in right scapula area... (2 answers)
I am a 56 year old female with tingling in my right shoulder blade and some tenderness. I have occasional breast discomfort in the same side and sometimes my rt. nipple feels sensitive. If I touch the area, the symptom on the nipple vanishes. at times the tingling travels into my neck and symptoms seem more noticeable in the evening. If I shower in a warm shower the symptoms will vanish for a time.. All my mammograms have been normal and never miss any but it has me very worried. I check my breasts often for lumps. From time to time it also seems like I have tenderness along the sternum on that side. I have rhematoid arthritis as well as was recently told I have osteoporosis. I had a thoracic x-ray and they can see loss of bone density and some vertebrae degeneration. Take methotrexate each week and folic acid every day....Any ideas out there???? Thanks
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I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.
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