Review: could Methotrexate cause Pulmonary Fibrosis?


Summary

Pulmonary fibrosis is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 2 - 5 years, also take medication Folic Acid, and have Rheumatoid arthritis . We study 128,586 people who have side effects while taking Methotrexate from FDA and social media. Among them, 934 have Pulmonary fibrosis. Find out below who they are, when they have Pulmonary fibrosis and more.

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Methotrexate

Methotrexate has active ingredients of methotrexate. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 129,243 users)

Pulmonary Fibrosis

Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs) has been reported by people with death, chills, hypotension, disease progression, pneumonia (latest reports from 9,748 Pulmonary fibrosis patients).

On Jul, 20, 2016

128,586 people reported to have side effects when taking Methotrexate.
Among them, 934 people (0.73%) have Pulmonary Fibrosis


Number of reports submitted per year:

Could Methotrexate cause Pulmonary fibrosis?

Time on Methotrexate when people have Pulmonary Fibrosis *:

  • < 1 month: 8.04 %
  • 1 - 6 months: 18.09 %
  • 6 - 12 months: 11.56 %
  • 1 - 2 years: 15.08 %
  • 2 - 5 years: 22.11 %
  • 5 - 10 years: 17.09 %
  • 10+ years: 8.04 %

Gender of people who have Pulmonary Fibrosis when taking Methotrexate *:

  • female: 60.97 %
  • male: 39.03 %

Age of people who have Pulmonary Fibrosis when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.81 %
  • 10-19: 1.89 %
  • 20-29: 1.08 %
  • 30-39: 3.92 %
  • 40-49: 5.0 %
  • 50-59: 15.68 %
  • 60+: 71.62 %

Severity if Pulmonary Fibrosis when taking Methotrexate **:

  • least: 0.0 %
  • moderate: 0.0 %
  • severe: 100 %
  • most severe: 0.0 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (421 people)
  • Osteoporosis (22 people)
  • Psoriatic Arthropathy (21 people)
  • Depression (18 people)
  • Prophylaxis (17 people)

Top co-used drugs for these people *:

  • Folic Acid (247 people)
  • Remicade (168 people)
  • Prednisone (148 people)
  • Enbrel (130 people)
  • Humira (119 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Pulmonary fibrosis when taking Methotrexate?

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Drugs that are associated with Pulmonary fibrosis

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Could your condition cause Pulmonary fibrosis

Pulmonary fibrosis

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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