Methotrexate and Pulmonary fibrosis - from FDA reports


Summary

Pulmonary fibrosis is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 2 - 5 years, also take medication Folic Acid, and have Rheumatoid arthritis . We study 209,150 people who have side effects while taking Methotrexate from FDA. Among them, 1,195 have Pulmonary fibrosis. Find out below who they are, when they have Pulmonary fibrosis and more.

What to expect?

If you take Methotrexate and have Pulmonary fibrosis, find out what symptoms you could have in 1 year or longer.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,557 users)

Pulmonary Fibrosis

Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs) has been reported by people with rheumatoid arthritis, idiopathic pulmonary fibrosis, osteoporosis, high blood pressure, atrial fibrillation/flutter (latest reports from 20,695 Pulmonary fibrosis patients).

On Jan, 24, 2017

209,150 people reported to have side effects when taking Methotrexate.
Among them, 1,195 people (0.57%) have Pulmonary Fibrosis


Number of reports submitted per year:

Could Methotrexate cause Pulmonary fibrosis?

Time on Methotrexate when people have Pulmonary Fibrosis *:

  • < 1 month: 7.02 %
  • 1 - 6 months: 15.29 %
  • 6 - 12 months: 10.33 %
  • 1 - 2 years: 15.7 %
  • 2 - 5 years: 22.73 %
  • 5 - 10 years: 19.83 %
  • 10+ years: 9.09 %

Gender of people who have Pulmonary Fibrosis when taking Methotrexate *:

  • female: 58.97 %
  • male: 41.03 %

Age of people who have Pulmonary Fibrosis when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 1.19 %
  • 10-19: 2.27 %
  • 20-29: 0.76 %
  • 30-39: 3.99 %
  • 40-49: 4.75 %
  • 50-59: 17.15 %
  • 60+: 69.9 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (645 people, 53.97%)
  • High Blood Pressure (39 people, 3.26%)
  • Psoriatic Arthropathy (33 people, 2.76%)
  • Osteoporosis (29 people, 2.43%)
  • Pain (21 people, 1.76%)

Top co-used drugs for these people *:

  • Folic Acid (266 people, 22.26%)
  • Enbrel (209 people, 17.49%)
  • Humira (184 people, 15.40%)
  • Remicade (182 people, 15.23%)
  • Prednisone (174 people, 14.56%)

Top other side effects for these people *:

  • Pneumonia (253 people, 21.17%)
  • Breathing Difficulty (159 people, 13.31%)
  • Interstitial Lung Disease (125 people, 10.46%)
  • Respiratory Acidosis (109 people, 9.12%)
  • Cough (106 people, 8.87%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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