Review: could Methotrexate cause Pulmonary Fibrosis?


Summary

Pulmonary fibrosis is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 2 - 5 years, also take medication Folic Acid, and have Rheumatoid arthritis . We study 191,458 people who have side effects while taking Methotrexate from FDA and social media. Among them, 1,066 have Pulmonary fibrosis. Find out below who they are, when they have Pulmonary fibrosis and more.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 205,730 users)

Pulmonary Fibrosis

Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs) has been reported by people with weight decreased, breathing difficulty, appetite - decreased, weakness, diarrhea (latest reports from 17,682 Pulmonary fibrosis patients).

On Sep, 18, 2016

191,458 people reported to have side effects when taking Methotrexate.
Among them, 1,066 people (0.56%) have Pulmonary Fibrosis


Number of reports submitted per year:

Could Methotrexate cause Pulmonary fibrosis?

Time on Methotrexate when people have Pulmonary Fibrosis *:

  • < 1 month: 6.7 %
  • 1 - 6 months: 15.79 %
  • 6 - 12 months: 12.44 %
  • 1 - 2 years: 15.79 %
  • 2 - 5 years: 21.53 %
  • 5 - 10 years: 20.57 %
  • 10+ years: 7.18 %

Gender of people who have Pulmonary Fibrosis when taking Methotrexate *:

  • female: 58.7 %
  • male: 41.3 %

Age of people who have Pulmonary Fibrosis when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 1.32 %
  • 10-19: 2.04 %
  • 20-29: 0.84 %
  • 30-39: 3.85 %
  • 40-49: 4.69 %
  • 50-59: 17.79 %
  • 60+: 69.47 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (565 people, 53.00%)
  • Psoriatic Arthropathy (31 people, 2.91%)
  • Osteoporosis (28 people, 2.63%)
  • Hypertension (28 people, 2.63%)
  • Prophylaxis (20 people, 1.88%)

Top co-used drugs for these people *:

  • Folic Acid (252 people, 23.64%)
  • Remicade (177 people, 16.60%)
  • Enbrel (170 people, 15.95%)
  • Prednisone (164 people, 15.38%)
  • Humira (162 people, 15.20%)

Top other side effects for these people *:

  • Pneumonia (159 people, 14.92%)
  • Dyspnoea (147 people, 13.79%)
  • Interstitial Lung Disease (114 people, 10.69%)
  • Respiratory Failure (95 people, 8.91%)
  • Pyrexia (95 people, 8.91%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Pulmonary fibrosis when taking Methotrexate?

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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