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Review: could Methotrexate cause Pulmonary fibrosis (Idiopathic pulmonary fibrosis)?

Summary: Pulmonary fibrosis is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Folic acid, and have Rheumatoid arthritis.

We study 129,882 people who have side effects while taking Methotrexate from FDA and social media. Among them, 894 have Pulmonary fibrosis. Find out below who they are, when they have Pulmonary fibrosis and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Pulmonary fibrosis >>>

 

 

 

 

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,224 Methotrexate users)

Pulmonary fibrosis

Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs) has been reported by people with rheumatoid arthritis, osteoporosis, high blood pressure, idiopathic pulmonary fibrosis, high blood cholesterol. (latest reports from 10,006 Pulmonary fibrosis patients)

On Jan, 15, 2015: 129,882 people reported to have side effects when taking Methotrexate. Among them, 894 people (0.69%) have Pulmonary Fibrosis.

Trend of Pulmonary fibrosis in Methotrexate reports

Time on Methotrexate when people have Pulmonary fibrosis * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Pulmonary fibrosis7.11%16.89%11.56%15.56%24.89%15.56%8.44%

Gender of people who have Pulmonary fibrosis when taking Methotrexate * :

FemaleMale
Pulmonary fibrosis61.91%38.09%

Age of people who have Pulmonary fibrosis when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Pulmonary fibrosis0.00%0.99%1.98%0.99%3.58%4.69%16.17%71.60%

Severity of Pulmonary fibrosis when taking Methotrexate ** :

leastmoderateseveremost severe
Pulmonary fibrosis0.00%0.00%100.00%0.00%

How people recovered from Pulmonary fibrosis ** :

n/a

Top conditions involved for these people * :

  1. Rheumatoid arthritis (498 people, 55.70%)
  2. Osteoporosis (23 people, 2.57%)
  3. Psoriatic arthropathy (22 people, 2.46%)
  4. Depression (21 people, 2.35%)
  5. Hypertension (19 people, 2.13%)

Top co-used drugs for these people * :

  1. Folic acid (321 people, 35.91%)
  2. Humira (193 people, 21.59%)
  3. Remicade (181 people, 20.25%)
  4. Prednisone (161 people, 18.01%)
  5. Enbrel (137 people, 15.32%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Pulmonary Fibrosis while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Pulmonary Fibrosis
- support group for people who take Methotrexate
- support group for people who have Pulmonary Fibrosis

Recent conversations of related support groups:

Drugs in real world that are associated with:

Could your condition cause:

Can you answer these questions (Ask a question):

  • What does unmasking mean; and does it mean that i always had hight cholesterol and triglycerides, or did actemra increase them?
    I have failed many RA meds, and now receive actemera x's 10 months I have never had high cholesterol or triglycerides and did not get my cholesterol checked except for the baseline 2/2014 and 12/2014 I was 198 TChol and now am 245; my tri up 85 points. my MD said that now that my inflammation is normal it shows my true cholestorol. I don't understand.
  • Is it safe to take zocalo if you are taking humora and methotrexate
    Is it safe to take all three of these together? I need to know if there is any adverse side effects of taking these drugs at the same time?
  • Does anyone take oral methotrexate and use topical magnesium chloride oil. if you do, do you have any side effects?
    I would like to try the Magnesium Chloride topical oil, but because of the oral MTX, I was wondering if anyone was taking/using this combination and if there were any side effects to watch for.....
  • Can viral myositis make my mysathenai gravis flare up? (1 answer)
    I am feeling weak, out of breath, and have difficulty walking due to my swelling, achiness, and slight pain! I was feeling fine just a few weeks ago......... had traveled and had no complaints........
  • Hlab27 antigen and unexplained scratches caused by accutane
    Guinea pig user of Accutane 1982. Experimental drug (told at that time) when a woman hits menopause we are not sure what will happen. I have hit early menopause 42 to be exact. Conjunctivitis, unexplained swelling in fingers, toes, kness, pseudogout (not normal according to my rheumatologist) unexplained scratches in same location, forearms, lower thigh (by knee) fingers. Scratches always are in a line with a break in the line. When a woman hits menopause hormones cease and when this happens the path that Accutane takes to cease sebaceous gland function, skin proliferation ceases. Therefore, my friends the HLA B27 (abnormal antigen targeted for skin proliferation does not know where to go so it randomly attacks whatever organ it chooses. Accutane if I remember correctly and I do have proof, permanently alters DNA. There is no other way orally ingesting a retinolic acid it could control skin, hormonal cesessation. I have only been diagnosed thus far with psoriatic arthritis with no other explanations for these other symptoms. I wonder why this is and I also wonder why dermatologists refuse to take a biopsy of my skin to rule out cell skin proliferation dysfunction. What will this damaging drug attack next. Do no be fooled by Dr.s who tell you that you took this drug so long ago how could this be. Well folks, it is because it has already changed your DNA to the HLAB27 antigen. My question also is, what was supposed to be where this abnormal DNA antigen is and how come this antigen only shows up at menopause. My disease (autoimmune) is progressive) and has already attacked nervous, muscle, skin, joints etc. Interesting

More questions for: Methotrexate, Pulmonary fibrosis

You may be interested at these reviews (Write a review):

  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
  • Personalized review of arava (1 response)
    Have had RA for 10 years and was on Methotrexate those 10 years. Had nose bleeds which got progressively worse over the years and began to effect my quality of living. Doctor said it could NOT be the drug, but according to eHealth Me, it could. At urging of an ENT, I stopped taking Methotrexate and the nose bleeds have now almost completely stopped. My doctor put me on Arava 3 days ago and I am on eHealth to study the effects of it.

More reviews for: Methotrexate, Pulmonary fibrosis

Comments from related studies:

  • From this study (1 week ago):

  • Since taking my last methotrexate injection I have had gastritis/pancreatitis. Previously had ercp twice.

    Reply

  • From this study (2 weeks ago):

  • Happening for a year

    Reply

  • From this study (3 weeks ago):

  • I have been diagnosed with idiopathic pulmonary fibrosis

    Reply

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