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Review: could Methotrexate cause Rash (Rashes)?

Summary: Rash is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Folic acid, and have Rheumatoid arthritis.

We study 129,882 people who have side effects while taking Methotrexate from FDA and social media. Among them, 3,988 have Rash. Find out below who they are, when they have Rash and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Rash >>>

 

 

 

 

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,233 Methotrexate users)

Rash

Rash (redness) has been reported by people with rheumatoid arthritis, high blood pressure, high blood cholesterol, osteoporosis, depression. (latest reports from 150,999 Rash patients)

On Jan, 28, 2015: 129,882 people reported to have side effects when taking Methotrexate. Among them, 3,988 people (3.07%) have Rash.

Trend of Rash in Methotrexate reports

Time on Methotrexate when people have Rash * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Rash34.82%20.94%13.18%8.00%11.76%8.00%3.29%

Gender of people who have Rash when taking Methotrexate * :

FemaleMale
Rash74.37%25.63%

Age of people who have Rash when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Rash0.38%3.42%6.85%3.75%8.05%16.70%23.11%37.73%

Severity of Rash when taking Methotrexate ** :

leastmoderateseveremost severe
Rash7.14%71.43%14.29%7.14%

How people recovered from Rash ** :

while on the drugafter off the drugnot yet
Rash0.00%12.50%87.50%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (2,490 people, 62.44%)
  2. Pain (292 people, 7.32%)
  3. Psoriatic arthropathy (280 people, 7.02%)
  4. Hypertension (232 people, 5.82%)
  5. Prophylaxis (228 people, 5.72%)

Top co-used drugs for these people * :

  1. Folic acid (1,500 people, 37.61%)
  2. Humira (1,433 people, 35.93%)
  3. Enbrel (910 people, 22.82%)
  4. Prednisone (754 people, 18.91%)
  5. Remicade (673 people, 16.88%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Rash while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Rash
- support group for people who take Methotrexate
- support group for people who have Rash

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More questions for: Methotrexate, Rash

You may be interested at these reviews (Write a review):

  • Lamotrigine severe rash
    I started taking 100mg of Teva-Lamotrigine Nov 22 once daily. I got a refill on Dec 5 that was Mylan-Lamotrigine. Two days later I woke up with an odd hot feeling rash all over my body and severe fatigue. I went back to bed 1/2 hour later after taking my regular Wellbutrin and the Lamotrigine. I woke up late morning. It got progressively worse during the day and I had a headache,fever and chills. I took the anti-histimine Aerius later that day which didn't help. The next day I went to a walk in clinic and they said it wasn't the Lamotrigine and thought it was a virus and did a throat swab. The fever and chills went away after a few days but I still have the rash. Finally after a week I saw a doctor that agreed it was the drug and I am now on the second week of Prednisone steroid treatment and prescription Reactin which is helping slowly. I have reported it to the Mylan drug company.
  • Rash from eating kale
    I ate kale for the first time on Monday. I only had a small bowl of fresh mixed green salad, so it wasn't entirely Kale. By Tuesday, I had a small rash on my left hip. I ignored it at first. Thursday evening, I decided to eat a large kale salad with other veggies and salmon, all of which I have eaten regularly aside from kale. Friday morning, my entire body was covered in the same rash that appeared Tuesday. I went to the ER. The doc said it was some type of allergic reaction. The ONLY thing I did/consumed different was the kale. I can't find much about it's reactions, though.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.

More reviews for: Methotrexate, Rash

Comments from related studies:

  • From this study (6 months ago):

  • I have developed a rash on my upper arms, elbows, back and groin areas

    Reply

    Dennis Walter on Aug, 2, 2014:

    That sound like a Fixed drug eruption

    Reply

  • From this study (13 months ago):

  • There are red circles that seem to keep getting bigger on my arms, leg, stomach, backend,shoulder,and my neck! They are not going away and getting bigger. The doctors have given me different diagnosises and the most recent is that I have ringworm, but because methotrexate weakens the immune system(it is an immune suppressent) that the ringworm is spreading quickly and getting bigger!

    Reply

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