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Review: could Methotrexate cause Rash (Rashes)?

Summary: Rash is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Folic acid, and have Rheumatoid arthritis.

We study 129,897 people who have side effects while taking Methotrexate from FDA and social media. Among them, 3,876 have Rash. Find out below who they are, when they have Rash and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Rash >>>

 

 

 

 

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,236 Methotrexate users)

Rash

Rash (redness) has been reported by people with rheumatoid arthritis, high blood pressure, high blood cholesterol, depression, osteoporosis. (latest reports from 151,029 Rash patients)

On Feb, 28, 2015: 129,897 people reported to have side effects when taking Methotrexate. Among them, 3,988 people (3.07%) have Rash.

Trend of Rash in Methotrexate reports

Time on Methotrexate when people have Rash * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Rash34.82%20.94%13.18%8.00%11.76%8.00%3.29%

Gender of people who have Rash when taking Methotrexate * :

FemaleMale
Rash74.37%25.63%

Age of people who have Rash when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Rash0.38%3.42%6.85%3.75%8.05%16.70%23.11%37.73%

Severity of Rash when taking Methotrexate ** :

leastmoderateseveremost severe
Rash7.14%71.43%14.29%7.14%

How people recovered from Rash ** :

while on the drugafter off the drugnot yet
Rash0.00%12.50%87.50%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (2,490 people, 62.44%)
  2. Pain (292 people, 7.32%)
  3. Psoriatic arthropathy (280 people, 7.02%)
  4. Hypertension (232 people, 5.82%)
  5. Prophylaxis (228 people, 5.72%)

Top co-used drugs for these people * :

  1. Folic acid (1,500 people, 37.61%)
  2. Humira (1,433 people, 35.93%)
  3. Enbrel (910 people, 22.82%)
  4. Prednisone (754 people, 18.91%)
  5. Remicade (673 people, 16.88%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Methotrexate and rash on

Do you have Rash while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Rash
- support group for people who take Methotrexate
- support group for people who have Rash

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Can you answer these questions (Ask a question):

  • What is the mortality rate for septicemia
    A single sleepwalking episode. Recent termination of cigarette use.
  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
  • Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
    I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?
  • What does unmasking mean; and does it mean that i always had hight cholesterol and triglycerides, or did actemra increase them?
    I have failed many RA meds, and now receive actemera x's 10 months I have never had high cholesterol or triglycerides and did not get my cholesterol checked except for the baseline 2/2014 and 12/2014 I was 198 TChol and now am 245; my tri up 85 points. my MD said that now that my inflammation is normal it shows my true cholestorol. I don't understand.

More questions for: Methotrexate, Rash

You may be interested at these reviews (Write a review):

  • Lamotrigine severe rash
    I started taking 100mg of Teva-Lamotrigine Nov 22 once daily. I got a refill on Dec 5 that was Mylan-Lamotrigine. Two days later I woke up with an odd hot feeling rash all over my body and severe fatigue. I went back to bed 1/2 hour later after taking my regular Wellbutrin and the Lamotrigine. I woke up late morning. It got progressively worse during the day and I had a headache,fever and chills. I took the anti-histimine Aerius later that day which didn't help. The next day I went to a walk in clinic and they said it wasn't the Lamotrigine and thought it was a virus and did a throat swab. The fever and chills went away after a few days but I still have the rash. Finally after a week I saw a doctor that agreed it was the drug and I am now on the second week of Prednisone steroid treatment and prescription Reactin which is helping slowly. I have reported it to the Mylan drug company.
  • Rash from eating kale
    I ate kale for the first time on Monday. I only had a small bowl of fresh mixed green salad, so it wasn't entirely Kale. By Tuesday, I had a small rash on my left hip. I ignored it at first. Thursday evening, I decided to eat a large kale salad with other veggies and salmon, all of which I have eaten regularly aside from kale. Friday morning, my entire body was covered in the same rash that appeared Tuesday. I went to the ER. The doc said it was some type of allergic reaction. The ONLY thing I did/consumed different was the kale. I can't find much about it's reactions, though.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.

More reviews for: Methotrexate, Rash

Comments from related studies:

  • From this study (7 months ago):

  • I have developed a rash on my upper arms, elbows, back and groin areas

    Reply

    Dennis Walter on Aug, 2, 2014:

    That sound like a Fixed drug eruption

    Reply

  • From this study (1 year ago):

  • There are red circles that seem to keep getting bigger on my arms, leg, stomach, backend,shoulder,and my neck! They are not going away and getting bigger. The doctors have given me different diagnosises and the most recent is that I have ringworm, but because methotrexate weakens the immune system(it is an immune suppressent) that the ringworm is spreading quickly and getting bigger!

    Reply

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