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Review: could Methotrexate cause Rash?

Summary: Rash could be caused by Methotrexate, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take Folic acid, and have Rheumatoid arthritis.

We study 129,658 people who have side effects while taking Methotrexate from FDA and social media. Among them, 3,874 have Rash. Find out below who they are, when they have Rash and more.

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Methotrexate

Methotrexate (latest outcomes from 130,985 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

Rash

Rash (redness) (latest reports from 965,510 patients) has been reported by people with rheumatoid arthritis, high blood pressure, high blood cholesterol, osteoporosis, depression.

On Apr, 11, 2014: 129,615 people reported to have side effects when taking Methotrexate. Among them, 3,986 people (3.08%) have Rash. They amount to 0.41% of all the 963,694 people who have Rash on eHealthMe.

Trend of Rash in Methotrexate reports

Time on Methotrexate when people have Rash * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Rash34.99%20.80%13.24%8.04%11.82%7.80%3.31%

Gender of people who have Rash when taking Methotrexate * :

FemaleMale
Rash74.36%25.64%

Age of people who have Rash when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Rash0.38%3.42%6.85%3.75%8.03%16.71%23.12%37.73%

Severity of Rash when taking Methotrexate ** :

leastmoderateseveremost severe
Rash8.33%66.67%16.67%8.33%

How people recovered from Rash ** :

while on the drugafter off the drugnot yet
Rash0.00%16.67%83.33%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (2,489 people, 62.44%)
  2. Pain (292 people, 7.33%)
  3. Psoriatic arthropathy (280 people, 7.02%)
  4. Hypertension (232 people, 5.82%)
  5. Prophylaxis (228 people, 5.72%)

Top co-used drugs for these people * :

  1. Folic acid (1,500 people, 37.63%)
  2. Humira (1,433 people, 35.95%)
  3. Enbrel (910 people, 22.83%)
  4. Prednisone (754 people, 18.92%)
  5. Remicade (673 people, 16.88%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Methotrexate, Rash

You can also:

On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Methotrexate used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (4 months ago):

  • There are red circles that seem to keep getting bigger on my arms, leg, stomach, backend,shoulder,and my neck! They are not going away and getting bigger. The doctors have given me different diagnosises and the most recent is that I have ringworm, but because methotrexate weakens the immune system(it is an immune suppressent) that the ringworm is spreading quickly and getting bigger!

    Reply

  • From this study (2 years ago):

  • I started taking the methotrexate yesterday. I have a fine raised red rash on my hands up to my elbows. It's itchy but not really bad.

    Reply

  • From this study (2 years ago):

  • Mrs Susan Spence on Dec, 9, 2011:

    WITHOUT YOUR HELP I WOULD NEVER HAVE KNOWN WHY I STARTED SLEEP WALKING AND ASHAMED TO SAY WET THE BED. I HAVE PSORIASIS ARTHRITIS AND WAS STARTED ON PLAQUENIL WHILST ALREADY TAKING A HIGH DOSE OF AMITRIPTYLINE. DURING SLEEP WALKING I FELL OVER AND CRACKED MY HEAD SERIOUSLY. WITHIN 48 HOURS OF WITHDRAWING MYSELF OFF PLAQUENIL I WAS BACK TO NORMAL. THANKYOU SO MUCH. I AM PASSING THIS ON TO THE HEALTH PROFESSIONALS THAT NEED TO KNOW.

    Reply

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