Methotrexate and Renal failure - from FDA reports


Summary

Renal failure is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Prednisone, and have Rheumatoid arthritis . We study 209,150 people who have side effects while taking Methotrexate from FDA. Among them, 1,699 have Renal failure. Find out below who they are, when they have Renal failure and more.

What to expect?

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,560 users)

Renal Failure

Renal failure (kidney dysfunction) has been reported by people with high blood pressure, multiple myeloma, coronary artery bypass, diabetes, rheumatoid arthritis (latest reports from 82,171 Renal failure patients).

On Feb, 06, 2017

209,150 people reported to have side effects when taking Methotrexate.
Among them, 1,699 people (0.81%) have Renal Failure


Number of reports submitted per year:

Could Methotrexate cause Renal failure?

Time on Methotrexate when people have Renal Failure *:

  • < 1 month: 48.73 %
  • 1 - 6 months: 8.23 %
  • 6 - 12 months: 6.65 %
  • 1 - 2 years: 9.49 %
  • 2 - 5 years: 11.71 %
  • 5 - 10 years: 8.86 %
  • 10+ years: 6.33 %

Gender of people who have Renal Failure when taking Methotrexate *:

  • female: 56.44 %
  • male: 43.56 %

Age of people who have Renal Failure when taking Methotrexate *:

  • 0-1: 0.68 %
  • 2-9: 2.66 %
  • 10-19: 12.97 %
  • 20-29: 3.34 %
  • 30-39: 4.86 %
  • 40-49: 12.67 %
  • 50-59: 20.56 %
  • 60+: 42.26 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (607 people, 35.73%)
  • High Blood Pressure (106 people, 6.24%)
  • Acute Lymphocytic Leukemia (all) (89 people, 5.24%)
  • Osteoporosis (81 people, 4.77%)
  • Preventive Health Care (65 people, 3.83%)

Top co-used drugs for these people *:

  • Prednisone (273 people, 16.07%)
  • Humira (263 people, 15.48%)
  • Folic Acid (259 people, 15.24%)
  • Enbrel (188 people, 11.07%)
  • Remicade (183 people, 10.77%)

Top other side effects for these people *:

  • Sepsis (252 people, 14.83%)
  • Pneumonia (215 people, 12.65%)
  • Fever (202 people, 11.89%)
  • Diarrhea (201 people, 11.83%)
  • Anaemia (189 people, 11.12%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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