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Review: could Methotrexate cause Renal failure?

Summary: Renal failure could be caused by Methotrexate, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take Prednisone, and have Rheumatoid arthritis.

We study 129,658 people who have side effects while taking Methotrexate from FDA and social media. Among them, 1,150 have Renal failure. Find out below who they are, when they have Renal failure and more.

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Methotrexate

Methotrexate (latest outcomes from 130,985 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

Renal failure

Renal failure (kidney dysfunction) (latest reports from 424,509 patients) has been reported by people with high blood pressure, coronary artery bypass, diabetes, multiple myeloma, pain.

On Apr, 12, 2014: 129,658 people reported to have side effects when taking Methotrexate. Among them, 1,417 people (1.09%) have Renal Failure. They amount to 0.33% of all the 430,136 people who have Renal Failure on eHealthMe.

Trend of Renal failure in Methotrexate reports

Time on Methotrexate when people have Renal failure * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Renal failure48.57%8.57%6.79%8.57%15.71%7.14%4.64%

Gender of people who have Renal failure when taking Methotrexate * :

FemaleMale
Renal failure58.46%41.54%

Age of people who have Renal failure when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Renal failure0.72%3.06%15.38%3.70%4.91%13.12%19.81%39.29%

Severity of Renal failure when taking Methotrexate ** :

leastmoderateseveremost severe
Renal failure0.00%50.00%50.00%0.00%

How people recovered from Renal failure ** :

n/a

Top conditions involved for these people * :

  1. Rheumatoid arthritis (461 people, 32.53%)
  2. Hypertension (77 people, 5.43%)
  3. Osteoporosis (72 people, 5.08%)
  4. Acute lymphocytic leukaemia (67 people, 4.73%)
  5. Prophylaxis (46 people, 3.25%)

Top co-used drugs for these people * :

  1. Prednisone (312 people, 22.02%)
  2. Folic acid (287 people, 20.25%)
  3. Humira (219 people, 15.46%)
  4. Cyclophosphamide (218 people, 15.38%)
  5. Remicade (197 people, 13.90%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Methotrexate, Renal failure

You can also:

On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Methotrexate used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (13 months ago):

  • I had a little recovery of the renal function since y stop azulfidine an methtrexate, a week ago

    Reply

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