Review: could Methotrexate cause Shortness of breath (Breathing difficulty)?
Summary: Shortness of breath is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Folic acid, and have Rheumatoid arthritis. We study 129,934 people who have side effects while taking Methotrexate from FDA and social media. Among them, 4,489 have Shortness of breath. Find out below who they are, when they have Shortness of breath and more.
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Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,279 Methotrexate users)
Shortness of breath
Shortness of breath has been reported by people with high blood pressure, asthma, rheumatoid arthritis, pain, chronic obstructive pulmonary disease. (latest reports from 165,511 Shortness of breath patients)
On May, 5, 2015: 129,925 people reported to have side effects when taking Methotrexate. Among them, 3,588 people (2.76%) have Shortness Of Breath.
Time on Methotrexate when people have Shortness of breath * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
|Shortness of breath||18.91%||25.51%||9.11%||11.16%||18.22%||12.07%||5.01% |
Gender of people who have Shortness of breath when taking Methotrexate * :
|Shortness of breath||72.10%||27.90% |
Age of people who have Shortness of breath when taking Methotrexate * :
|Shortness of breath||0.51%||1.57%||3.42%||4.19%||7.78%||13.92%||22.14%||46.46% |
Severity of Shortness of breath when taking Methotrexate ** :
|least||moderate||severe||most severe |
|Shortness of breath||8.00%||56.00%||28.00%||8.00% |
How people recovered from Shortness of breath ** :
|while on the drug||after off the drug||not yet |
|Shortness of breath||4.55%||9.09%||86.36% |
Top conditions involved for these people * :
- Rheumatoid arthritis (2,220 people, 61.87%)
- Pain (273 people, 7.61%)
- Hypertension (244 people, 6.80%)
- Psoriatic arthropathy (213 people, 5.94%)
- Arthritis (139 people, 3.87%)
Top co-used drugs for these people * :
- Folic acid (1,335 people, 37.21%)
- Humira (1,111 people, 30.96%)
- Remicade (718 people, 20.01%)
- Prednisone (676 people, 18.84%)
- Enbrel (570 people, 15.89%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
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Comments from related studies:
From this study (1 month ago):
Have taken methotrexate for 20 plus years. Decided to up my dosage from 10 mg to 12.5 mg about 3 months ago... then to 15 mg shortly after. I also have a history of asthma, but currently non-active.
From this study (9 months ago):
Sarcoidosis caused complete heart block. Pacemaker implanted in December 2009 but for the past two years I have had palpitations caused by around 3.7 million ectopic heartbeats per year.
Sarcoidosis also in lungs and eyes. Extended use of Pred Forte caused development of cataracts, one of which has been removed and I am awaiting the second operation.
Breathlessness is caused by lack of oxygen entering the bloodstream and my ongoing heart problems
Rarely able to sleep properly due to pain, sleeping for about 20 minutes at a time when I become so exhausted that the pain can't keep me awake
Muscle and joint pain have made me weak and clumsy.Pain is felt all over, from head to toes along with muscle cramps and intense burning sensation to skin on lower legs.
ACE levels fluctuate but average 110 - 150.
Blood pressure on average is 150 / 78 - no treatment given
I also take Nefopam Hydrochloride (Acupan) for pain but this drug is not on the list.
Immobility, fatigue and constant pain have left me very depressed ad harbouring thoughts of suicide. My 15 year old granddaughter has lived with me since the death of my daughter 11 years ago and it is my hope that I will live long enough to see her settled in college and independent after which the only thing I have to look forward to is to end my own suffering.
IchikireiLV on Sep, 5, 2014:
I was so sorry to read your comment, but glad I encountered it. PLEASE PLEASE don't ever think of taking your own life! I know what it is like to suffer. I injured myself 7 yrs ago, got a spinal implant that failed, compressed my spine, corroded and left me with heavy metal toxicity which caused adrenal failure, hypothyroid and many other serious health conditions. I have lived a life of chronic pain, fatigue and difficulty, so I know exactly where you are coming from! Some days I am so weak and have so much pain that I cannot get out of bed or care for myself. At times I try to puch myself to do the simplest things and my body is so frail I can barely catch my breath and feel like I gave to crawl back to my bed, dripping in sweat, dehydrated and defeated... but I still go on in hopes that there will be a better day. I ENCOURAGE YOU TO SEE A PAIN MANAGEMENT DR. MONTHLY FOR MEDICATIONS TO CONTROL YOUR PAIN! This alone will improve your daily life immensely! Pain will make you depressed! I also use Savella. It helps with Neuropathy pain AND DEPRESSION. Dont give up because doctors arent helping you enough. MAKE THEM! Its unacceptable that they are not following thru but I myself have experienced this many times.. Find another better, more compassionate Dr. Read Dr. reviews online, start with a primary care family dr, a pain dr and a rhuematologist for Sarcoidosis... make sure the Dr. is experienced with Sarcoidosis.. if not, find another one. I hope this helps you and gives you a direction to follow. Once your pain is controlled, things will be a lot better. Good luck and wishes of health and most of all HOPE and HAPPINESS 😄😄
Kath Nugent on Aug, 26, 2014:
I was diagnosed with Lymphatic Sarcoidosis 15 years ago. After massive weight loss, a node in my neck the size of a small egg, and at the same time an
area of my gum opened up were i had a tooth removed 20 years earlier, Sarcoid grew out of this opening !!it was like a piece of green string. My GP & Consultant tried to pull it out but failed,it was about an inch long. i was sent away with no further appointment, So i went to see my Dentist who seemed to know what it was and sent me to the Hospital Dentist who did a jaw bone Scraping and arranged for the node in neck to be removed for biopsy, both biopsy came back as Sarcoidosis. i was then x rayed and was found to have it in on my lungs as well. at this point i had active Sarcoidosis in my Lymphatic system, bone, lungs. However it as never been active in my lungs !!! it did however eat away the inside of my nose, it attacked my eyes i almost went blind, i lost my balance,it was in my brain.
i was so tired, and after so many steroids i was having a bad reaction to them in various organs and was taken of them. i did recover from this as the Sarcoid went dormant. i have recently been diagnosed with a brain tumor and raised platelets. given that Sarcoidosis is next door to Cancer and that i feel absolutely wasted and week!!! i am feeling anxious about the outcome of more tests. But we all have to go sometime and i know there are people out there worse than me !!! i send you all love & light and hope we can all have the strength to help each other through whatever is thrown at us!! not easy by any means. Happy to answer any questions if it will help anyone Take care Kath Nugent
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