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Review: could Methotrexate cause Skin depigmentation?

Summary: Skin depigmentation is found among people who take Methotrexate, especially for people who are male, 30-39 old, also take medication Humira, and have Rheumatoid arthritis.

We study 129,908 people who have side effects while taking Methotrexate from FDA and social media. Among them, 9 have Skin depigmentation. Find out below who they are, when they have Skin depigmentation and more.

You are not alone: join a support group for people who take Methotrexate and have Skin depigmentation >>>



Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,250 Methotrexate users)

Skin depigmentation

Skin depigmentation (lightening of the skin) has been reported by people with rheumatoid arthritis, hepatitis c, high blood pressure, diabetes, birth control. (latest reports from 462 Skin depigmentation patients)

On Mar, 17, 2015: 129,897 people reported to have side effects when taking Methotrexate. Among them, 9 people (0.01%) have Skin Depigmentation.

Trend of Skin depigmentation in Methotrexate reports

Time on Methotrexate when people have Skin depigmentation * :


Gender of people who have Skin depigmentation when taking Methotrexate * :

Skin depigmentation50.00%50.00%

Age of people who have Skin depigmentation when taking Methotrexate * :

Skin depigmentation0.00%0.00%11.11%0.00%44.44%22.22%11.11%11.11%

Severity of Skin depigmentation when taking Methotrexate ** :


How people recovered from Skin depigmentation ** :


Top conditions involved for these people * :

  1. Rheumatoid arthritis (5 people, 55.56%)
  2. Hypersensitivity (1 people, 11.11%)
  3. Migraine (1 people, 11.11%)
  4. Psoriatic arthropathy (1 people, 11.11%)
  5. Bronchopulmonary aspergillosis (1 people, 11.11%)

Top co-used drugs for these people * :

  1. Humira (5 people, 55.56%)
  2. Cyclosporine (4 people, 44.44%)
  3. Methylprednisolone (3 people, 33.33%)
  4. Kestine (1 people, 11.11%)
  5. Emerge (1 people, 11.11%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of methotrexate and skin depigmentation on

Do you have Skin Depigmentation while taking Methotrexate?




You are not alone! Join a mobile support group on :
- support group for people who take Methotrexate and have Skin Depigmentation
- support group for people who take Methotrexate
- support group for people who have Skin Depigmentation

Drugs in real world that are associated with:

Could your condition cause:

Recent related drug studies (Check your drugs):

Recent Methotrexate related drug comparison:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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