Review: could Methotrexate cause Squamous Cell Carcinoma?


Squamous cell carcinoma is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 2 - 5 years, also take medication Folic Acid, and have Rheumatoid arthritis . We study 197,008 people who have side effects while taking Methotrexate from FDA and social media. Among them, 492 have Squamous cell carcinoma. Find out below who they are, when they have Squamous cell carcinoma and more.

Personalized health information

On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 86 million people have used us. 300+ peer-reviewed medical journals have referenced our original studies. Start now >>>


Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,455 users)

Squamous Cell Carcinoma

Squamous cell carcinoma (a cancer of a kind of epithelial cell) has been reported by people with rheumatoid arthritis, psoriasis, osteoporosis, high blood pressure, crohn's disease (latest reports from 7,391 Squamous cell carcinoma patients).

On Oct, 18, 2016

197,008 people reported to have side effects when taking Methotrexate.
Among them, 492 people (0.25%) have Squamous Cell Carcinoma

Number of reports submitted per year:

Could Methotrexate cause Squamous cell carcinoma?

Time on Methotrexate when people have Squamous Cell Carcinoma *:

  • < 1 month: 9.43 %
  • 1 - 6 months: 5.66 %
  • 6 - 12 months: 11.32 %
  • 1 - 2 years: 11.32 %
  • 2 - 5 years: 43.4 %
  • 5 - 10 years: 18.87 %
  • 10+ years: 0.0 %

Gender of people who have Squamous Cell Carcinoma when taking Methotrexate *:

  • female: 55.15 %
  • male: 44.85 %

Age of people who have Squamous Cell Carcinoma when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.58 %
  • 10-19: 0.87 %
  • 20-29: 0.0 %
  • 30-39: 1.73 %
  • 40-49: 7.8 %
  • 50-59: 23.7 %
  • 60+: 65.32 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (285 people, 57.93%)
  • Psoriasis (43 people, 8.74%)
  • Psoriatic Arthropathy (38 people, 7.72%)
  • Hypertension (25 people, 5.08%)
  • Crohn's Disease (17 people, 3.46%)

Top co-used drugs for these people *:

  • Folic Acid (153 people, 31.10%)
  • Remicade (136 people, 27.64%)
  • Humira (83 people, 16.87%)
  • Enbrel (63 people, 12.80%)
  • Prednisone (55 people, 11.18%)

Top other side effects for these people *:

  • Basal Cell Carcinoma (74 people, 15.04%)
  • Skin Cancer (17 people, 3.46%)
  • Rheumatoid Arthritis (17 people, 3.46%)
  • Actinic Keratosis (17 people, 3.46%)
  • Weight Decreased (16 people, 3.25%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Squamous cell carcinoma when taking Methotrexate?

Browse all side effects of Methotrexate

a b c d e f g h i j k l m n o p q r s t u v w x y z

Drugs that are associated with Squamous cell carcinoma

Squamous cell carcinoma

Could your condition cause Squamous cell carcinoma

Squamous cell carcinoma

Related studies

Can you answer these questions?

More questions for: Methotrexate, Squamous cell carcinoma

You may be interested in these reviews

More reviews for: Methotrexate, Squamous cell carcinoma

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.