Methotrexate and Squamous cell carcinoma - from FDA reports


Summary

Squamous cell carcinoma is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 2 - 5 years, also take medication Folic Acid, and have Rheumatoid arthritis . We study 209,150 people who have side effects while taking Methotrexate from FDA. Among them, 529 have Squamous cell carcinoma. Find out below who they are, when they have Squamous cell carcinoma and more.

What to expect?

If you take Methotrexate and have Squamous cell carcinoma, find out what symptoms you could have in 1 year or longer.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,557 users)

Squamous Cell Carcinoma

Squamous cell carcinoma (a cancer of a kind of epithelial cell) has been reported by people with rheumatoid arthritis, psoriasis, osteoporosis, high blood pressure, crohn's disease (latest reports from 7,394 Squamous cell carcinoma patients).

On Feb, 05, 2017

209,150 people reported to have side effects when taking Methotrexate.
Among them, 529 people (0.25%) have Squamous Cell Carcinoma


Number of reports submitted per year:

Could Methotrexate cause Squamous cell carcinoma?

Time on Methotrexate when people have Squamous Cell Carcinoma *:

  • < 1 month: 9.09 %
  • 1 - 6 months: 7.27 %
  • 6 - 12 months: 10.91 %
  • 1 - 2 years: 10.91 %
  • 2 - 5 years: 43.64 %
  • 5 - 10 years: 18.18 %
  • 10+ years: 0.0 %

Gender of people who have Squamous Cell Carcinoma when taking Methotrexate *:

  • female: 54.31 %
  • male: 45.69 %

Age of people who have Squamous Cell Carcinoma when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.53 %
  • 10-19: 0.8 %
  • 20-29: 0.0 %
  • 30-39: 1.59 %
  • 40-49: 8.49 %
  • 50-59: 24.67 %
  • 60+: 63.93 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (306 people, 57.84%)
  • Psoriasis (49 people, 9.26%)
  • Psoriatic Arthropathy (39 people, 7.37%)
  • High Blood Pressure (26 people, 4.91%)
  • Crohn's Disease (18 people, 3.40%)

Top co-used drugs for these people *:

  • Folic Acid (155 people, 29.30%)
  • Remicade (143 people, 27.03%)
  • Humira (85 people, 16.07%)
  • Enbrel (68 people, 12.85%)
  • Prednisone (59 people, 11.15%)

Top other side effects for these people *:

  • Basal Cell Carcinoma (75 people, 14.18%)
  • Skin Cancer (20 people, 3.78%)
  • Actinic Keratosis (20 people, 3.78%)
  • Rheumatoid Arthritis (17 people, 3.21%)
  • Weight Decreased (16 people, 3.02%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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