Methotrexate and Venoocclusive liver disease - from FDA reports


Summary

Venoocclusive liver disease is found among people who take Methotrexate, especially for people who are male, 2-9 old , have been taking the drug for < 1 month, also take medication Cyclophosphamide, and have Stem cell transplant. This review analyzes which people have Venoocclusive liver disease with Methotrexate. It is created by eHealthMe based on reports of 223,372 people who have side effects when taking Methotrexate from FDA, and is updated regularly.

What to expect?

If you take Methotrexate and have Venoocclusive liver disease, find out what symptoms you could have in 1 year or longer.

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On May, 13, 2017

223,372 people reported to have side effects when taking Methotrexate.
Among them, 393 people (0.18%) have Venoocclusive Liver Disease


Number of reports submitted per year:

Could Methotrexate cause Venoocclusive liver disease?

Time on Methotrexate when people have Venoocclusive Liver Disease *:

  • < 1 month: 90.72 %
  • 1 - 6 months: 6.19 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 3.09 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Venoocclusive Liver Disease when taking Methotrexate *:

  • female: 39.88 %
  • male: 60.12 %

Age of people who have Venoocclusive Liver Disease when taking Methotrexate *:

  • 0-1: 6.95 %
  • 2-9: 24.5 %
  • 10-19: 12.25 %
  • 20-29: 14.9 %
  • 30-39: 5.63 %
  • 40-49: 9.6 %
  • 50-59: 15.23 %
  • 60+: 10.93 %

Top conditions involved for these people *:

  • Stem Cell Transplant (76 people, 19.34%)
  • Bone Marrow Conditioning Regimen (53 people, 13.49%)
  • Graft Versus Host Disease (50 people, 12.72%)
  • Acute Lymphocytic Leukemia (all) (50 people, 12.72%)
  • Preventive Health Care (46 people, 11.70%)

Top co-used drugs for these people *:

  • Cyclophosphamide (125 people, 31.81%)
  • Cyclosporine (114 people, 29.01%)
  • Tacrolimus (82 people, 20.87%)
  • Prograf (69 people, 17.56%)
  • Busulfan (51 people, 12.98%)

Top other side effects for these people *:

  • Fever (53 people, 13.49%)
  • Ascites (50 people, 12.72%)
  • Graft Versus Host Disease (46 people, 11.70%)
  • Thrombocytopenia (44 people, 11.20%)
  • Hepatomegaly (44 people, 11.20%)

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Venoocclusive liver disease when taking Methotrexate?

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 226,881 users)

Venoocclusive Liver Disease

Venoocclusive liver disease (small veins in the liver are obstructed) has been reported by people with acute myeloid leukaemia, stem cell transplant, bone marrow conditioning regimen, preventive health care, acute lymphocytic leukemia (all) (latest reports from 2,180 Venoocclusive liver disease patients).

Browse all side effects of Methotrexate

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Drugs that are associated with Venoocclusive liver disease

Venoocclusive liver disease

Could your condition cause Venoocclusive liver disease

Venoocclusive liver disease

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What would happen?

Forecast new side effects and undetected conditions when you take Methotrexate and have Venoocclusive liver disease.

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