Methotrexate and Venoocclusive liver disease - from FDA reports


Summary

Venoocclusive liver disease is found among people who take Methotrexate, especially for people who are male, 2-9 old , have been taking the drug for < 1 month, also take medication Cyclophosphamide, and have Stem cell transplant . We study 209,150 people who have side effects while taking Methotrexate from FDA. Among them, 381 have Venoocclusive liver disease. Find out below who they are, when they have Venoocclusive liver disease and more.

What to expect?

If you take Methotrexate and have Venoocclusive liver disease, find out what symptoms you could have in 1 year or longer.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,557 users)

Venoocclusive Liver Disease

Venoocclusive liver disease (small veins in the liver are obstructed) has been reported by people with acute myeloid leukaemia, stem cell transplant, bone marrow conditioning regimen, preventive health care, acute lymphocytic leukemia (all) (latest reports from 2,055 Venoocclusive liver disease patients).

On Feb, 08, 2017

209,150 people reported to have side effects when taking Methotrexate.
Among them, 381 people (0.18%) have Venoocclusive Liver Disease


Number of reports submitted per year:

Could Methotrexate cause Venoocclusive liver disease?

Time on Methotrexate when people have Venoocclusive Liver Disease *:

  • < 1 month: 93.1 %
  • 1 - 6 months: 3.45 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 3.45 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Venoocclusive Liver Disease when taking Methotrexate *:

  • female: 40.19 %
  • male: 59.81 %

Age of people who have Venoocclusive Liver Disease when taking Methotrexate *:

  • 0-1: 7.19 %
  • 2-9: 25.0 %
  • 10-19: 12.67 %
  • 20-29: 14.38 %
  • 30-39: 5.82 %
  • 40-49: 9.93 %
  • 50-59: 15.41 %
  • 60+: 9.59 %

Top conditions involved for these people *:

  • Stem Cell Transplant (76 people, 19.95%)
  • Bone Marrow Conditioning Regimen (51 people, 13.39%)
  • Graft Versus Host Disease (50 people, 13.12%)
  • Preventive Health Care (44 people, 11.55%)
  • Acute Lymphocytic Leukemia (all) (44 people, 11.55%)

Top co-used drugs for these people *:

  • Cyclophosphamide (125 people, 32.81%)
  • Cyclosporine (114 people, 29.92%)
  • Tacrolimus (82 people, 21.52%)
  • Prograf (68 people, 17.85%)
  • Busulfan (51 people, 13.39%)

Top other side effects for these people *:

  • Fever (51 people, 13.39%)
  • Ascites (50 people, 13.12%)
  • Graft Versus Host Disease (46 people, 12.07%)
  • Hepatomegaly (44 people, 11.55%)
  • Thrombocytopenia (43 people, 11.29%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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