Review: could Methotrexate cause Venoocclusive Liver Disease?


Venoocclusive liver disease is found among people who take Methotrexate, especially for people who are male, 2-9 old , have been taking the drug for < 1 month, also take medication Cyclosporine, and have Stem cell transplant . We study 128,586 people who have side effects while taking Methotrexate from FDA and social media. Among them, 336 have Venoocclusive liver disease. Find out below who they are, when they have Venoocclusive liver disease and more.

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It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 129,243 users)

Venoocclusive Liver Disease

Venoocclusive liver disease (small veins in the liver are obstructed) has been reported by people with multi-organ failure, disseminated intravascular coagulation, sinusitis, pneumonia, rhabdomyosarcoma (latest reports from 1,551 Venoocclusive liver disease patients).

On Jul, 23, 2016

128,586 people reported to have side effects when taking Methotrexate.
Among them, 336 people (0.26%) have Venoocclusive Liver Disease

Number of reports submitted per year:

Could Methotrexate cause Venoocclusive liver disease?

Time on Methotrexate when people have Venoocclusive Liver Disease *:

  • < 1 month: 92.68 %
  • 1 - 6 months: 3.66 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 3.66 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Venoocclusive Liver Disease when taking Methotrexate *:

  • female: 43.45 %
  • male: 56.55 %

Age of people who have Venoocclusive Liver Disease when taking Methotrexate *:

  • 0-1: 6.1 %
  • 2-9: 23.98 %
  • 10-19: 14.23 %
  • 20-29: 15.04 %
  • 30-39: 4.47 %
  • 40-49: 11.38 %
  • 50-59: 19.92 %
  • 60+: 4.88 %

Top conditions involved for these people *:

  • Stem Cell Transplant (69 people)
  • Graft Versus Host Disease (45 people)
  • Bone Marrow Transplant (38 people)
  • Bone Marrow Conditioning Regimen (31 people)
  • Prophylaxis (24 people)

Top co-used drugs for these people *:

  • Cyclosporine (112 people)
  • Cyclophosphamide (109 people)
  • Tacrolimus (78 people)
  • Prograf (60 people)
  • Acyclovir (41 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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