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Review: could Methotrexate cause Venoocclusive liver disease?

Summary: Venoocclusive liver disease could be caused by Methotrexate, especially for people who are male, 2-9 old, have been taking the drug for < 1 month, also take Cyclosporine, and have Bone marrow conditioning regimen.

We study 129,658 people who have side effects while taking Methotrexate from FDA and social media. Among them, 303 have Venoocclusive liver disease. Find out below who they are, when they have Venoocclusive liver disease and more.

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Methotrexate

Methotrexate (latest outcomes from 130,985 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis, psoriatic arthritis. Commonly reported side effects of Methotrexate include fever, injection site pain, joint pain, rheumatoid arthritis aggravated, nausea.

Venoocclusive liver disease

Venoocclusive liver disease (small veins in the liver are obstructed) (latest reports from 7,637 patients) has been reported by people with acute myeloid leukaemia, stem cell transplant, prophylaxis against graft versus host disease, bone marrow conditioning regimen, bone marrow transplant.

On Apr, 9, 2014: 129,615 people reported to have side effects when taking Methotrexate. Among them, 303 people (0.23%) have Venoocclusive Liver Disease. They amount to 3.98% of all the 7,619 people who have Venoocclusive Liver Disease on eHealthMe.

Trend of Venoocclusive liver disease in Methotrexate reports

Time on Methotrexate when people have Venoocclusive liver disease * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Venoocclusive liver disease92.68%3.66%0.00%3.66%0.00%0.00%0.00%

Gender of people who have Venoocclusive liver disease when taking Methotrexate * :

FemaleMale
Venoocclusive liver disease42.81%57.19%

Age of people who have Venoocclusive liver disease when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Venoocclusive liver disease5.88%24.31%14.12%16.47%4.31%10.98%19.22%4.71%

Severity of Venoocclusive liver disease when taking Methotrexate ** :

n/a

How people recovered from Venoocclusive liver disease ** :

n/a

Top conditions involved for these people * :

  1. Bone marrow conditioning regimen (46 people, 15.18%)
  2. Graft versus host disease (46 people, 15.18%)
  3. Prophylaxis (40 people, 13.20%)
  4. Bone marrow transplant (38 people, 12.54%)
  5. Acute lymphocytic leukaemia (24 people, 7.92%)

Top co-used drugs for these people * :

  1. Cyclosporine (132 people, 43.56%)
  2. Cyclophosphamide (126 people, 41.58%)
  3. Tacrolimus (91 people, 30.03%)
  4. Prograf (66 people, 21.78%)
  5. Acyclovir (52 people, 17.16%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Methotrexate, Venoocclusive liver disease

You can also:

On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Methotrexate used for and how effective is it:

Other drugs that are used to treat the same conditions:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (1 day ago):

  • Trying to determine if the timing of these drugs- especially the weekly mtx- should be staggered during the day to ensure they are appropriately absorbed. Periodic seizures continue- about once a quarter.

    Reply

  • From this study (3 days ago):

  • I never had any symptoms of raynauds until is was put on methotrexate,and then Enbrel,and now Humira.I used a automotive laser thermometer to check my arm
    temp. which was 97 degrees,however my fingers on the same arm were between
    69-72 degrees.

    Reply

  • From this study (4 days ago):

  • Dosage for methotrexate is 15 to 17 mg. over ten year period.
    Have been taking about 800 mg. of frolic acid per day, plus whatever occurs naturally in food.
    For about a year have been dealing with urinary retention. Don't know if there is a connection.
    Will be seeing my doctor tomorrow .

    Also take generic Zantac

    Reply

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- Methotrexate side effects

 

Related symptom

- Venoocclusive Liver Disease

 

 

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