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Review: could Methotrexate cause Vomiting?

Summary: Vomiting could be caused by Methotrexate, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take Folic acid, and have Rheumatoid arthritis.

We study 129,658 people who have side effects while taking Methotrexate from FDA and social media. Among them, 3,178 have Vomiting. Find out below who they are, when they have Vomiting and more.

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Methotrexate

Methotrexate (latest outcomes from 130,985 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis, psoriatic arthritis. Commonly reported side effects of Methotrexate include fever, injection site pain, joint pain, rheumatoid arthritis aggravated, nausea.

Vomiting

Vomiting (latest reports from 1,061,990 patients) has been reported by people with high blood pressure, pain, pain relief by acupuncture, acupuncture and pain, type 2 diabetes.

On Apr, 13, 2014: 129,658 people reported to have side effects when taking Methotrexate. Among them, 3,865 people (2.98%) have Vomiting. They amount to 0.36% of all the 1,059,980 people who have Vomiting on eHealthMe.

Trend of Vomiting in Methotrexate reports

Time on Methotrexate when people have Vomiting * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Vomiting38.82%20.39%9.65%10.75%13.82%4.39%2.19%

Gender of people who have Vomiting when taking Methotrexate * :

FemaleMale
Vomiting73.59%26.41%

Age of people who have Vomiting when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Vomiting0.58%8.39%11.77%4.52%9.15%12.82%20.69%32.06%

Severity of Vomiting when taking Methotrexate ** :

leastmoderateseveremost severe
Vomiting0.00%58.33%33.33%8.33%

How people recovered from Vomiting ** :

while on the drugafter off the drugnot yet
Vomiting0.00%14.29%85.71%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (1,601 people, 41.42%)
  2. Pain (240 people, 6.21%)
  3. Prophylaxis (172 people, 4.45%)
  4. Hypertension (167 people, 4.32%)
  5. Osteoporosis (146 people, 3.78%)

Top co-used drugs for these people * :

  1. Folic acid (1,122 people, 29.03%)
  2. Humira (751 people, 19.43%)
  3. Prednisone (724 people, 18.73%)
  4. Enbrel (607 people, 15.71%)
  5. Remicade (570 people, 14.75%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Methotrexate, Vomiting

You can also:

On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Methotrexate used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (2 years ago):

  • godsgirl on Apr, 27, 2011:

    Started enbrel in Sept. 2010.Have had R.A. since I was teenty-four am now 55,I have had four cases of choking, not sure if it has anything to do with my non stop sinus infection..but I am planning to get off it.Was hoping someone else had some info about this choking crap

    Reply

    sue nicholls on Dec, 26, 2011:

    i startted on Embrel Sept. 2011 it took approx 3 months before i saw any positive effects, ihave had chest inf. and 2 flare ups, what bothers me most is constant nausea and dry heaving and fatigue, the pain is managable now but my quality of life is not very good as i am too tired to do much of anything although this is preferable to the pain, i feel as if i am between a rock and a hard place!

    Reply

    rlpainter on Mar, 29, 2012:

    Fatigue appears to be progressive. I have less and less energy.

    Reply

  • From this study (3 years ago):

  • AL GYAM on Jul, 27, 2011:

    I use Spironolactone to treat my high blood pressure and experience abnormal dreams accompanied by screamiong. It has happened 2 times within a month.
    Al

    Reply

    AL GYAM on Jul, 27, 2011:

    AL GYAM

    Sex: Male
    Age: 60 +
    I use Spironolactone to treat my high blood pressure and experience abnormal dreams accompanied by screaming. It has happened 2 times within a month.
    Al

    Reply

  • From this study (3 years ago):

  • I started out taking Methotrexate tablets with Folic Acid and Meloxocam. The Nausea and Vomiting would last for three days and I couldn't get out of bed. The Rheumatologist switched me to Methotrexate Injections and told me to stay on the Folic Acid and Meloxocam and the nausea would ease up. However, it did not. I would take my injections on Monday and still spent 2 1/2 to 3 days with my head in the trash can and unable to get out of bed. When I finally did get to feeling better, it was time to start over again. Then after 16 weeks of treatment I developed 23 lbs of cysts on my ovaries and had to have the ovaries, tubes, and cysts removed. I lost six teeth while taking the medication. The exhaustion never eased at all. After 16 weeks, I stopped the medication to have the partial hysterectomy. My Rheumatologist then wanted me to start on Humaria injections. Humaria comes with a warning that if you have ever had cancer you shouldn't take this medication. I previously had cervical cancer and discussed this with my physician. His response: "Well...if you get cancer from taking this medication then it is just your bad luck." Needless to say I was speechless. I have not started taking the Humaria and am off the Methotrexate, Folic Acid, and Meloxocam. My swelling and pain symptoms are worse and I am still very tired (but I also have Fibromyalgia, Chronic Fatigue and Sleep Apnea) but I know longer have my head in the trash can and do not spend three days at a time in bed.

    Reply

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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