Review: could Methotrexate cause Weight Gain?


Summary

Weight gain is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Enbrel, and have Rheumatoid arthritis . We study 191,459 people who have side effects while taking Methotrexate from FDA and social media. Among them, 2,357 have Weight gain. Find out below who they are, when they have Weight gain and more.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 205,727 users)

Weight Gain

Weight gain has been reported by people with breathing difficulty, abdominal pain, memory loss, fatigue, dizziness (latest reports from 114,274 Weight gain patients).

On Sep, 18, 2016

191,459 people reported to have side effects when taking Methotrexate.
Among them, 2,357 people (1.23%) have Weight Gain


Number of reports submitted per year:

Could Methotrexate cause Weight gain?

Time on Methotrexate when people have Weight Gain *:

  • < 1 month: 46.4 %
  • 1 - 6 months: 14.4 %
  • 6 - 12 months: 6.4 %
  • 1 - 2 years: 14.4 %
  • 2 - 5 years: 10.4 %
  • 5 - 10 years: 5.6 %
  • 10+ years: 2.4 %

Gender of people who have Weight Gain when taking Methotrexate *:

  • female: 80.46 %
  • male: 19.54 %

Age of people who have Weight Gain when taking Methotrexate *:

  • 0-1: 0.22 %
  • 2-9: 2.29 %
  • 10-19: 3.1 %
  • 20-29: 4.03 %
  • 30-39: 8.92 %
  • 40-49: 18.82 %
  • 50-59: 30.58 %
  • 60+: 32.05 %

Severity if Weight Gain when taking Methotrexate **:

  • least: 0.0 %
  • moderate: 66.67 %
  • severe: 25.0 %
  • most severe: 8.33 %

How people recovered from Weight Gain **:

  • while on drug: 0.0 %
  • after off the drug: 0.0 %
  • not yet: 100 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (1,331 people, 56.47%)
  • Pain (195 people, 8.27%)
  • Hypertension (153 people, 6.49%)
  • Psoriatic Arthropathy (139 people, 5.90%)
  • Depression (93 people, 3.95%)

Top co-used drugs for these people *:

  • Enbrel (682 people, 28.94%)
  • Folic Acid (552 people, 23.42%)
  • Humira (482 people, 20.45%)
  • Prednisone (449 people, 19.05%)
  • Folic Acid. (330 people, 14.00%)

Top other side effects for these people *:

  • Arthralgia (447 people, 18.96%)
  • Pain (376 people, 15.95%)
  • Fatigue (340 people, 14.43%)
  • Drug Ineffective (276 people, 11.71%)
  • Headache (253 people, 10.73%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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