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Review: could Methotrexate cause Weight gain (Weight increased)?

Summary: Weight gain is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Folic acid, and have Rheumatoid arthritis.

We study 129,882 people who have side effects while taking Methotrexate from FDA and social media. Among them, 1,304 have Weight gain. Find out below who they are, when they have Weight gain and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Weight gain >>>

 

 

 

 

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,224 Methotrexate users)

Weight gain

Weight gain has been reported by people with depression, high blood pressure, bipolar disorder, pain, high blood cholesterol. (latest reports from 76,545 Weight gain patients)

On Jan, 25, 2015: 129,882 people reported to have side effects when taking Methotrexate. Among them, 1,304 people (1.00%) have Weight Gain.

Trend of Weight gain in Methotrexate reports

Time on Methotrexate when people have Weight gain * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Weight gain47.32%20.54%4.46%12.50%9.82%3.57%1.79%

Gender of people who have Weight gain when taking Methotrexate * :

FemaleMale
Weight gain80.61%19.39%

Age of people who have Weight gain when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Weight gain0.27%3.29%4.80%4.89%11.47%19.64%27.56%28.09%

Severity of Weight gain when taking Methotrexate ** :

leastmoderateseveremost severe
Weight gain7.14%50.00%28.57%14.29%

How people recovered from Weight gain ** :

while on the drugafter off the drugnot yet
Weight gain0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (663 people, 50.84%)
  2. Pain (140 people, 10.74%)
  3. Hypertension (86 people, 6.60%)
  4. Vitamin supplementation (63 people, 4.83%)
  5. Psoriatic arthropathy (58 people, 4.45%)

Top co-used drugs for these people * :

  1. Folic acid (440 people, 33.74%)
  2. Enbrel (437 people, 33.51%)
  3. Prednisone (362 people, 27.76%)
  4. Humira (335 people, 25.69%)
  5. Omeprazole (120 people, 9.20%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Weight Gain while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Weight Gain
- support group for people who take Methotrexate
- support group for people who have Weight Gain

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More questions for: Methotrexate, Weight gain

You may be interested at these reviews (Write a review):

  • Terbinafine hydrochloride
    I would not reccomend this at all. I was described this drug 6months ago. Bad side effects still ongoing rapid weight gain and water retention in putting on 2 stone in less than 6months. No menstrual in ya year Bloatingin the face arms legs and gut. Been to the doctors said nothing can be done so how much longer can you put up with ffeeling like this.should not be prescribed. Makes you feel dreadfull.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Lyrica varied widely
    I was prescribed Lyrica for treatment of chronic pain. It was ineffective, but it knocked out the symptoms of interstitial. However, it also caused rapid weight gain (I went from 110 to 130 lbs. in just a few weeks) and my ankles started to swell. The pain doctor advised me to discontinue the drug, but the urologist suggested lowering the dose. I did, and the swelling went down. I weighed myself daily and watched what I ate, and my weight returned to normal within a month. Subsequently, I continued taking the lower dose and had no further problems. Then I developed severe spinal stenosis, and my dosage of Lyrica was increased to six 75 capsules daily, in addition to 480 mg of morphine sulphate. I tolerated the Lyrica well. After surgery, however, my ankles began to swell again, and although I didn't have a problem with weight gain, I developed a bright red rash from ankles to knees. I dropped the dosage of Lyrica to 50 mg twice daily, and had no further side effects. The rash simply disappeared, with no damage to the skin. Following the surgery, I was able to titrate off morphine completely. I continue to take Lyrica twice daily. It doesn't seem to affect pain (I still ache a bit, as I have degenerative changes in all joints) but it does dampen peripheral neuropathy, which I experience both in my toes and balls of my feet. It also dampens the neuropathy in my forehead, where I had four surgeries to remove a malignant melanoma. I have had no side effects other than those mentioned, and find it interesting the I could tolerate a high dosage of Lyrica prior to surgery, but after surgery could not, and that adverse side effects varied not only with the dosage but with my own physical condition. I don't find it to be highly effective in treating neuropathy, but it does still the tingling enough to let me sleep and take my mind off the condition.
  • Crestor side effects (1 response)
    I'm a vegetarian all my life , very athletic, I work out a lot , I run. In the last year or two My cholesterol seems to go high, my primary Doctor knows that I go for the healthy stuff so he advice a couple of things. But unfortunately nothing woks so he put me on Crestor, it has been a really bad experience, my menstrual periods don't come normal anymore, or sometimes it takes two or three months to come back again. I have hot flashes day or night, and the last one is that I'm gaining weight. I'm not sure what to do, any pill will give you side effects, I never read side effects. I'm 100% percent this is not coincides is real an is happening to me.
  • Depo provera overdose
    Dr acidentially gave me something like 9 times the normal dose of depo provera. My life has been miserable! I have fought excessive weight gain, infertility, severe cellulite, and acne for 20 years.

More reviews for: Methotrexate, Weight gain

Comments from related studies:

  • From this study (5 months ago):

  • Took synthroid after birth of daugther, 12 years ago. Eventually came off synthroid while takine kelp and selenium. Joint aches and pains, especially knees and elbows. TSH 4.22, which has doubled since starting methotrexate.

    Reply

  • From this study (9 months ago):

  • The abnormal dreams & mild hallucinations came only after starting the methylprednisolone a few days ago. They happen primarily when I am sleeping. I woke up last night with very unusual dreams & head/brain pain, and was quite concerned. I had taken 1 methylprednisolone & 1 cymbalta before bed. Earlier in the day, I had taken 2 methylprednisolone & 2 tramadol before a nap, and had similar, though not as severe issues. Trying to figure out what the interaction problem is. I did not take the muscle relaxant (cyclopenzaprine) before bed since I started the cortico steroid pack.

    Reply

    britsarmymom on Apr, 26, 2014:

    Mother just survived near brush with respiratory arrest. Hallucinated at night on Tramadol, argumentative with RN who reported her to MD. He planned to ADD Seroquel 25 mg to Tramadol, Neurontin, Remeron and Ativan in rehab facility. She declined Tramadol and Seroquel and was still so sedated her pulse ox went down to 84 with long periods of apnea and need for constant obs with frequent rousing for airway. MAJOR struggle with RN to get 02 and MD agreed to no more Tramodol at night and absolutely no Seroquel. How many elderly are lost this way?

    Reply

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