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Home > Methotrexate > Weight gain > Methotrexate and Weight gain

Review: could Methotrexate cause Weight gain (Weight increased)?

Summary: Weight gain is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Folic acid, and have Rheumatoid arthritis.

We study 129,841 people who have side effects while taking Methotrexate from FDA and social media. Among them, 1,304 have Weight gain. Find out below who they are, when they have Weight gain and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Weight gain >>>

Methotrexate

Methotrexate (latest outcomes from 131,185 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

Trend of methotrexate reports

Weight gain

Weight gain (latest reports from 530,688 patients) has been reported by people with depression, high blood pressure, bipolar disorder, pain, high blood cholesterol.

Trend of Weight gain reports

On Oct, 25, 2014: 129,821 people reported to have side effects when taking Methotrexate. Among them, 1,304 people (1.00%) have Weight Gain.

Trend of Weight gain in Methotrexate reports

Time on Methotrexate when people have Weight gain * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Weight gain47.32%20.54%4.46%12.50%9.82%3.57%1.79%

Gender of people who have Weight gain when taking Methotrexate * :

FemaleMale
Weight gain80.61%19.39%

Age of people who have Weight gain when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Weight gain0.27%3.29%4.80%4.89%11.47%19.64%27.56%28.09%

Severity of Weight gain when taking Methotrexate ** :

leastmoderateseveremost severe
Weight gain7.14%50.00%28.57%14.29%

How people recovered from Weight gain ** :

while on the drugafter off the drugnot yet
Weight gain0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (663 people, 50.84%)
  2. Pain (140 people, 10.74%)
  3. Hypertension (86 people, 6.60%)
  4. Vitamin supplementation (63 people, 4.83%)
  5. Psoriatic arthropathy (58 people, 4.45%)

Top co-used drugs for these people * :

  1. Folic acid (440 people, 33.74%)
  2. Enbrel (437 people, 33.51%)
  3. Prednisone (362 people, 27.76%)
  4. Humira (335 people, 25.69%)
  5. Omeprazole (120 people, 9.20%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Weight Gain while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Weight Gain
- support group for people who take Methotrexate
- support group for people who have Weight Gain

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  • Are an increase in appetite & tiredness side effects of the birth control tri-sprintec?
    (Asked by a 23 year old woman who has Weight Gain, Increased Appetite, and takes Tri-sprintec)
    In the past I have taken the birth control Ortho Tri-Cyclen Lo and have never had any problems. I just switched to the generic brand, Tri-sprintec. I have now officially been taking Tri-Sprintec for 2 months. I recently started to notice that my appetite has increased and I've been eating A LOT more ...

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    (Asked by a 49 year old woman who has Scratches, Swelling, Burning, Nerve, Muscle Pain, Conjunctivitis, and takes Methotrexate)
    Guinea pig user of Accutane 1982. Experimental drug (told at that time) when a woman hits menopause we are not sure what will happen. I have hit early menopause 42 to be exact. Conjunctivitis, unexplained swelling in fingers, toes, kness, pseudogout (not normal according to my rheumatologist) une ...

  • Bisoprolol ,ive gained 56 pounds
    (Asked by a 60 year old man who has Weight Gain)
    i had a triple by pass,and was prescribed bisoprolol.since taking it i have gained 4 stones in weight ,ive tried diets ,exercise nothing takes the weight off ,should i stop the tablets.

  • Do the side effects of prolia either stop or lessen over the 6 month period between injections?
    (Asked by a 67 year old woman who has Back Pain, Acid Reflux, Fatigue, Abdominal Pain, Osteoarthritis Generalised, Headache - Mixed Tension Migraine, Itching, Weight Gain, Hot Flush, Musculoskeletal Discomfort, Pain - Abdomen, and takes Feraheme, Pantoprazole, Prolia)
    I am wondering if the side effects of Prolia go away or lessen during the six months it is taken for.

  • Has anybody had multi lobar pneumonia from reaction to methotrexate?
    (Asked by a 57 year old woman who has Migraine Without Aura, Anxiety And Stress, Major Depression With Psychotic Features, Bilateral Multilobar Pneumonia, Ankylosing Spondylitis, and takes Zyprexa, Methotrexate)
    Bilateral multilobar pneumonia - rheumatologist considers it was caused by a reaction to methotrexate I was taking for ankylosing spondylitis and I was lucky to survive. Anyone have this and later shown to have scarring of the lungs?

More questions for: Methotrexate, Weight gain

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  • Humira: my experience
    (Posted by a 66 year old man who has Ankylosing Spondylitis, Reiter's Syndrome, Psoriatic Arthritis, and takes Methotrexate Preservative Free, Enbrel, Humira)
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long. I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, ...

  • Lyrica varied widely
    (Posted by a 69 year old woman who has Peripheral Neuropathy, Chronic Pain, Bright-red Rash, Swelling Of Ankles, Weight Gain, and takes Lyrica)
    I was prescribed Lyrica for treatment of chronic pain. It was ineffective, but it knocked out the symptoms of interstitial. However, it also caused rapid weight gain (I went from 110 to 130 lbs. in just a few weeks) and my ankles started to swell. The pain doctor advised me to discontinue the dru ...

  • Crestor side effects
    (Posted by a 47 year old woman who has Weight Gain - Unintentional, Hot Flashes, Joint Swelling, Weight Gain, and takes Crestor)
    I'm a vegetarian all my life , very athletic, I work out a lot , I run. In the last year or two My cholesterol seems to go high, my primary Doctor knows that I go for the healthy stuff so he advice a couple of things. But unfortunately nothing woks so he put me on Crestor, it has been a really bad e ...

  • Depo provera overdose
    (Posted by a 47 year old woman who has Central Obesity, Obesity, Weight Gain, Exhaustion, Fatigue, Lethargy, Tiredness, Weariness, Vein Disorder, Milk Secretions, Libido Decreased, Infertility Female, Hair Loss, Bone Loss, Acne, Cellulite, Depression, and takes Depo-provera)
    Dr acidentially gave me something like 9 times the normal dose of depo provera. My life has been miserable! I have fought excessive weight gain, infertility, severe cellulite, and acne for 20 years.

  • Psoratic arthritis and trigeminal neuralgia
    (Posted by a 33 year old man who has Nasal Septum Deviation, Psoriasis, Psoriatic Arthritis, Trigeminal Neuralgia, Asthma Exercise Induced, and takes Methotrexate)
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic a ...

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