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Review: could Methotrexate cause Weight loss?





Summary: Weight loss is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Folic acid, and have Rheumatoid arthritis.

We study 129,858 people who have side effects while taking Methotrexate from FDA and social media. Among them, 110 have Weight loss. Find out below who they are, when they have Weight loss and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Weight loss >>>

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (view latest outcomes from 131,201 users)

Weight loss

Weight loss has been reported by people with depression, bipolar disorder, schizophrenia, high blood pressure, stress and anxiety.(latest reports from Weight loss 16,911 patients)

On Dec, 14, 2014: 129,841 people reported to have side effects when taking Methotrexate. Among them, 110 people (0.08%) have Weight Loss.

Trend of Weight loss in Methotrexate reports

Time on Methotrexate when people have Weight loss * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Weight loss0.00%14.29%14.29%14.29%28.57%14.29%14.29%

Gender of people who have Weight loss when taking Methotrexate * :

FemaleMale
Weight loss82.61%17.39%

Age of people who have Weight loss when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Weight loss0.00%7.77%2.91%3.88%14.56%15.53%27.18%28.16%

Severity of Weight loss when taking Methotrexate ** :

leastmoderateseveremost severe
Weight loss0.00%33.33%33.33%33.33%

How people recovered from Weight loss ** :

while on the drugafter off the drugnot yet
Weight loss0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (47 people, 42.73%)
  2. Psoriatic arthropathy (14 people, 12.73%)
  3. Breast cancer (12 people, 10.91%)
  4. Prophylaxis (11 people, 10.00%)
  5. Vitamin supplementation (10 people, 9.09%)

Top co-used drugs for these people * :

  1. Folic acid (32 people, 29.09%)
  2. Prednisone (25 people, 22.73%)
  3. Enbrel (22 people, 20.00%)
  4. Humira (19 people, 17.27%)
  5. Alprazolam (17 people, 15.45%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Weight Loss while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Weight Loss
- support group for people who take Methotrexate
- support group for people who have Weight Loss

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  • I am a 56 year old female with rheumatoid arthritis. i also have found out i have osteoporosis. i keep getting right breast sensitivity also tingling and tenderness in right scapula area... (2 answers)
    I am a 56 year old female with tingling in my right shoulder blade and some tenderness. I have occasional breast discomfort in the same side and sometimes my rt. nipple feels sensitive. If I touch the area, the symptom on the nipple vanishes. at times the tingling travels into my neck and symptoms seem more noticeable in the evening. If I shower in a warm shower the symptoms will vanish for a time.. All my mammograms have been normal and never miss any but it has me very worried. I check my breasts often for lumps. From time to time it also seems like I have tenderness along the sternum on that side. I have rhematoid arthritis as well as was recently told I have osteoporosis. I had a thoracic x-ray and they can see loss of bone density and some vertebrae degeneration. Take methotrexate each week and folic acid every day....Any ideas out there???? Thanks
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    40 mg Lipitor for two months caused 8 pounds weight loss,thoughts of losing my mind ,racing heart rate,mental confusion,emergency visits twice,never in my life have gone to hospital by ambulance..5'11 178 BM 17 ,faithful gym rat ,all test ruled out physical issues,informed doctor, he didn't feel Lipitor was the cause,I stopped Lipitor 3 weeks later not losing weight ,bad dreams gone,feeling like myself again,hoping to regain the weight in time,Lisinpril 10 mg started two years ago ,has issues but did not connect until recently,3 months after taking started to have problems in the bedroom,only within the last 5 months did it occur to me was that was the cause of my sexual performance...had all test done testosterone ,blood work and all came back normal,stopped taking Lisinpril for 4 days a my manhood returned to normal!! Just spoke with doctor and says that shouldn't be????? Really ,he has since written me a new BP prescription,recent BP readings have been normal and will not take until BP rises....eating better ,with supplements ,,why Doctors don't believe the patient is incredulous ,thanks to sites like this people need to really question the health care their getting .....
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  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
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  • I have had insomnia off and on all my life until I turned 40 and the I was diagnosed with Psoriatic Arthritis and I was tired all the time and I was sleeping a lot for me and it was good to be able to sleep. The doctor put me on Methotrexate and Enbrel and I could still sleep not as much as before ...
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More related studies for: Methotrexate, Weight loss

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