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Related topic: Methotrexate, Withdrawal syndrome

Review: could Methotrexate cause Withdrawal syndrome?

Summary: Withdrawal syndrome could be caused by Methotrexate, especially for people who are female, 30-39 old, have been taking the drug for < 1 month, also take Lyrica, and have Pain.

We study 129,668 people who have side effects while taking Methotrexate from FDA and social media. Among them, 44 have Withdrawal syndrome. Find out below who they are, when they have Withdrawal syndrome and more.

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Methotrexate

Methotrexate (latest outcomes from 130,985 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

Withdrawal syndrome

Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) (latest reports from 55,509 patients) has been reported by people with depression, pain, acupuncture and pain, stress and anxiety, muscle spasticity.

On Apr, 10, 2014: 129,615 people reported to have side effects when taking Methotrexate. Among them, 44 people (0.03%) have Withdrawal Syndrome. They amount to 0.08% of all the 55,257 people who have Withdrawal Syndrome on eHealthMe.

Trend of Withdrawal syndrome in Methotrexate reports

Time on Methotrexate when people have Withdrawal syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Withdrawal syndrome100.00%0.00%0.00%0.00%0.00%0.00%0.00%

Gender of people who have Withdrawal syndrome when taking Methotrexate * :

FemaleMale
Withdrawal syndrome79.25%20.75%

Age of people who have Withdrawal syndrome when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Withdrawal syndrome0.00%0.00%2.27%6.82%50.00%11.36%25.00%4.55%

Severity of Withdrawal syndrome when taking Methotrexate ** :

n/a

How people recovered from Withdrawal syndrome ** :

n/a

Top conditions involved for these people * :

  1. Pain (23 people, 52.27%)
  2. Rheumatoid arthritis (14 people, 31.82%)
  3. Fibromyalgia (12 people, 27.27%)
  4. Back pain (11 people, 25.00%)
  5. Depression (10 people, 22.73%)

Top co-used drugs for these people * :

  1. Lyrica (19 people, 43.18%)
  2. Folic acid (12 people, 27.27%)
  3. Fentanyl-100 (11 people, 25.00%)
  4. Oxycodone hcl (9 people, 20.45%)
  5. Percocet (8 people, 18.18%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

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On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Methotrexate used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

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  • From this study (2 days ago):

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