Review: could Methotrexate cause Withdrawal syndrome?
Summary: Withdrawal syndrome is found among people who take Methotrexate, especially for people who are female, 30-39 old, have been taking the drug for < 1 month, also take medication Lyrica, and have Pain.
We study 129,897 people who have side effects while taking Methotrexate from FDA and social media. Among them, 44 have Withdrawal syndrome. Find out below who they are, when they have Withdrawal syndrome and more.
You are not alone: join a mobile support group for people who take Methotrexate and have Withdrawal syndrome >>>
Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,243 Methotrexate users)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) has been reported by people with depression, pain, stress and anxiety, muscle spasticity, back pain. (latest reports from 9,228 Withdrawal syndrome patients)
On Feb, 16, 2015: 129,897 people reported to have side effects when taking Methotrexate. Among them, 44 people (0.03%) have Withdrawal Syndrome.
Time on Methotrexate when people have Withdrawal syndrome * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
|Withdrawal syndrome||100.00%||0.00%||0.00%||0.00%||0.00%||0.00%||0.00% |
Gender of people who have Withdrawal syndrome when taking Methotrexate * :
|Withdrawal syndrome||79.25%||20.75% |
Age of people who have Withdrawal syndrome when taking Methotrexate * :
|Withdrawal syndrome||0.00%||0.00%||2.27%||6.82%||50.00%||11.36%||25.00%||4.55% |
Severity of Withdrawal syndrome when taking Methotrexate ** :
How people recovered from Withdrawal syndrome ** :
Top conditions involved for these people * :
- Pain (23 people, 52.27%)
- Rheumatoid arthritis (14 people, 31.82%)
- Fibromyalgia (12 people, 27.27%)
- Back pain (11 people, 25.00%)
- Depression (10 people, 22.73%)
Top co-used drugs for these people * :
- Lyrica (19 people, 43.18%)
- Folic acid (12 people, 27.27%)
- Fentanyl-100 (11 people, 25.00%)
- Oxycodone hcl (9 people, 20.45%)
- Percocet (8 people, 18.18%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Get connected: join our support group of methotrexate and withdrawal syndrome on
Do you have Withdrawal Syndrome while taking Methotrexate?
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- support group for people who have Withdrawal Syndrome
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- Does humira cause excessive sweating?
Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
- Would the tinnitus abate with if i discontinue methotrexate?
I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
- Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?
- What does unmasking mean; and does it mean that i always had hight cholesterol and triglycerides, or did actemra increase them?
I have failed many RA meds, and now receive actemera x's 10 months I have never had high cholesterol or triglycerides and did not get my cholesterol checked except for the baseline 2/2014 and 12/2014 I was 198 TChol and now am 245; my tri up 85 points. my MD said that now that my inflammation is normal it shows my true cholestorol. I don't understand.
- Is it safe to take zocalo if you are taking humora and methotrexate
Is it safe to take all three of these together? I need to know if there is any adverse side effects of taking these drugs at the same time?
More questions for: Methotrexate, Withdrawal syndrome
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I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.
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- Psoratic arthritis and trigeminal neuralgia
hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
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Comments from related studies:
From this study (7 days ago):
I had the flu for two weeks it has been gone two weeks but I stayed fatigued with dry cough. I had my infusion of Simponi Aria 10 days ago. My Methotrexate injection is due tomorrow.
From this study (1 week ago):
motoboy on Jan, 29, 2015:
I've recently stopped taking ibuprofen after many years of taking it daily. I take between 800 to 1500 mg a day, mostly before bed to sleep. I have had a lot of sport injuries do it was for joint pain. It's been about a week since taking any and I'm getting really bad headaches. Can't seem to find this as a withdrawal issue... any one else experience this? Thanks!
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