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Review: could Methotrexate cause Withdrawal syndrome?





Summary: Withdrawal syndrome is found among people who take Methotrexate, especially for people who are female, 30-39 old, have been taking the drug for < 1 month, also take medication Lyrica, and have Pain.

We study 129,858 people who have side effects while taking Methotrexate from FDA and social media. Among them, 44 have Withdrawal syndrome. Find out below who they are, when they have Withdrawal syndrome and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Withdrawal syndrome >>>

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 131,201 users)

Withdrawal syndrome

Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) has been reported by people with depression, pain, stress and anxiety, muscle spasticity, back pain.(latest reports from Withdrawal syndrome 9,186 patients)

On Dec, 14, 2014: 129,858 people reported to have side effects when taking Methotrexate. Among them, 44 people (0.03%) have Withdrawal Syndrome.

Trend of Withdrawal syndrome in Methotrexate reports

Time on Methotrexate when people have Withdrawal syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Withdrawal syndrome100.00%0.00%0.00%0.00%0.00%0.00%0.00%

Gender of people who have Withdrawal syndrome when taking Methotrexate * :

FemaleMale
Withdrawal syndrome79.25%20.75%

Age of people who have Withdrawal syndrome when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Withdrawal syndrome0.00%0.00%2.27%6.82%50.00%11.36%25.00%4.55%

Severity of Withdrawal syndrome when taking Methotrexate ** :

n/a

How people recovered from Withdrawal syndrome ** :

n/a

Top conditions involved for these people * :

  1. Pain (23 people, 52.27%)
  2. Rheumatoid arthritis (14 people, 31.82%)
  3. Fibromyalgia (12 people, 27.27%)
  4. Back pain (11 people, 25.00%)
  5. Depression (10 people, 22.73%)

Top co-used drugs for these people * :

  1. Lyrica (19 people, 43.18%)
  2. Folic acid (12 people, 27.27%)
  3. Fentanyl-100 (11 people, 25.00%)
  4. Oxycodone hcl (9 people, 20.45%)
  5. Percocet (8 people, 18.18%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Withdrawal Syndrome while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Withdrawal Syndrome
- support group for people who take Methotrexate
- support group for people who have Withdrawal Syndrome

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