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Review: could Methotrexate cause Withdrawal syndrome?

We study 129,773 people who have side effects while taking Methotrexate from FDA and social media. Among them, 44 have Withdrawal syndrome. Find out below who they are, when they have Withdrawal syndrome and more.

Stay connected: join a mobile support group for people who take Methotrexate and have Withdrawal syndrome >>>

Methotrexate

Methotrexate (latest outcomes from 131,102 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

Withdrawal syndrome

Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) (latest reports from 56,363 patients) has been reported by people with depression, pain, stress and anxiety, muscle spasticity, back pain.

On Aug, 14, 2014: 129,757 people reported to have side effects when taking Methotrexate. Among them, 44 people (0.03%) have Withdrawal Syndrome. They amount to 0.08% of all the 56,357 people who have Withdrawal Syndrome on eHealthMe.

Trend of Withdrawal syndrome in Methotrexate reports

Time on Methotrexate when people have Withdrawal syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Withdrawal syndrome100.00%0.00%0.00%0.00%0.00%0.00%0.00%

Gender of people who have Withdrawal syndrome when taking Methotrexate * :

FemaleMale
Withdrawal syndrome79.25%20.75%

Age of people who have Withdrawal syndrome when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Withdrawal syndrome0.00%0.00%2.27%6.82%50.00%11.36%25.00%4.55%

Severity of Withdrawal syndrome when taking Methotrexate ** :

n/a

How people recovered from Withdrawal syndrome ** :

n/a

Top conditions involved for these people * :

  1. Pain (23 people, 52.27%)
  2. Rheumatoid arthritis (14 people, 31.82%)
  3. Fibromyalgia (12 people, 27.27%)
  4. Back pain (11 people, 25.00%)
  5. Depression (10 people, 22.73%)

Top co-used drugs for these people * :

  1. Lyrica (19 people, 43.18%)
  2. Folic acid (12 people, 27.27%)
  3. Fentanyl-100 (11 people, 25.00%)
  4. Oxycodone hcl (9 people, 20.45%)
  5. Percocet (8 people, 18.18%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group to help out with your experience or learn from others anytime and anywhere:
- group for people who take Methotrexate and have Withdrawal Syndrome
- group for people who take Methotrexate
- group for people who have Withdrawal Syndrome

Comments from related studies:

  • From this study (3 days ago):

  • I have been taking methotrexate 10 mg (one injection a week) since 2002. I was then under Metoject (Methotrexate) 10 mg and then 7.5 mg until February 2013 when I had mouth sores. I was told I had mouth cancer in April 2014 and has been operated mid May at the Pitie Salpetriere hospital in Paris.

    Reply

  • From this study (5 days ago):

  • I have exhausted all drug options for overactive bladder due to "resistance." Including Botox injections that had moderate results but only lasted almost two months. Also, every injection was painfully felt although I was prepped with a pain minimizing treatment. I am searching for help if any of my medication are causing the resistance.

    Reply

  • From this study (1 week ago):

  • I've been diagnosed with sero-negative rheumatoid arthritis. I have only tested minimally positive on the anti-CCP test and had a slightly high SED rate. My most recent tests showed some slight elevation in some RA marker tests, but nothing really significant. My rheumatologist is now doubting whether I have RA or some other pain syndrome going on.

    Reply

    IHateRA on Jul, 22, 2014:

    My first RA Dr. put me on Plaquenil, it seemed to work for six months, then stopped - I thought the dose would be adjusted but it wasn't, so I went to another RA Doc - C-RP wasn't too high, sero neg. Was put on methotrexate - I ended up with a mouth sore the NEXT day, then bumps started appearing on my face, like zits, but NOT zits. I didn't touch them, but they ulcerated, left me full of scars on face, legs, etc - I have been OFF methotrexate for 5 years AND still have the same problem along with a daily fever (100+) and severe sweating - I knew the bumps were a sign of being allergic to Methotrexate, I quit it right away, called Dr. to get in - they told me 3 months (I was an established patient). In terms of fever and sweating, the ONLY thing I have in common with some of these posts and drug lists is METHOTREXATE - I wouldn't allow a pet to take it. I seem to have more in common with a friend who as MS - but my reg. doc doesn't listen to that. I can't take bio. drugs (live in "fungal" region), so I take pain medicine - as little as possible, I guess the Methotrexate is STILL messing with my body. I have a very good acupuncturist - when I told him that my Doc. wasn't "sure" about RA, he poked me (lightly) with his finger in two places and ask which hurt more. He confirmed the RA as it travels on certain meridians in Chinese medicine. Had I picked a different spot for hurting more, then we would have to figure out what I really had. My joints are deteriorating but now I'm afraid of the drugs for RA, so I just put up with and manage the pain (which is extreme) with pain meds, cold therapy (I love my cryo-cuff), and acupuncture. I wish that the side effects of RA drugs weren't as bad as they are! Leaving Cymbalta, Lyrica, Plaquenil and Methotrexate (all at different times) OUT of my body made me realize that they did affect me - I was "foggy" and sluggish mentally but didn't really notice it until I quit them.

    Reply

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On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

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