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Review: could Niacin cause Mania?

Summary: Mania is reported only by a few people who take Niacin.

We study 5,767 people who have side effects while taking Niacin from FDA and social media. Among them, 4 have Mania. Find out below who they are, when they have Mania and more.

You are not alone: join a mobile support group for people who take Niacin and have Mania >>>






Niacin has active ingredients of niacin. It is often used in high blood cholesterol. (latest outcomes from 6,313 Niacin users)


Mania (a state of abnormally elevated or irritable mood) has been reported by people with bipolar disorder, depression, quit smoking, stress and anxiety, bipolar i disorder. (latest reports from 10,833 Mania patients)

On Dec, 30, 2014: 5,767 people reported to have side effects when taking Niacin. Among them, 4 people (0.07%) have Mania.

Trend of Mania in Niacin reports

Time on Niacin when people have Mania * :


Gender of people who have Mania when taking Niacin * :


Age of people who have Mania when taking Niacin * :


Severity of Mania when taking Niacin ** :


How people recovered from Mania ** :


Top conditions involved for these people * :

  1. Cognitive disorder (2 people, 50.00%)
  2. Bipolar i disorder (1 people, 25.00%)
  3. Autism spectrum disorder (1 people, 25.00%)
  4. Abnormal behaviour (1 people, 25.00%)

Top co-used drugs for these people * :

  1. Aricept (3 people, 75.00%)
  2. Pravastatin (2 people, 50.00%)
  3. Levothyroxine sodium (2 people, 50.00%)
  4. Propranolol hydrochloride (2 people, 50.00%)
  5. Tamsulosin hcl (2 people, 50.00%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Mania while taking Niacin?

You are not alone! Join a mobile support group:
- support group for people who take Niacin and have Mania
- support group for people who take Niacin
- support group for people who have Mania

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  • Will taking a fiber supplement at the same time as niaspan create a problem/interaction
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    will the niacin have a positive effect on my diabetic foot ulcer?

More questions for: Niacin, Mania

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More reviews for: Niacin, Mania

Comments from related studies:

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  • From this study (2 months ago):

  • I am a 61 year old female, who, after taking DESYREL / TRAZADONE 100mg per day, for 19 days, (Oct 25-Nov 13, 2014), developed a complete psychosis and was institutionalized for 4 days. I had awoken at 1am, Friday November 14, 2014 and was acting and feeling very strange, upon which my husband wisely chose to get me to the ER. I was given a HEAD CT, with negative findings, upon arrival.

    On November 14, 2014 I was "Baker Acted", (as I do reside in Florida), into a hellish psychiatric ward where care was minimal, at best. The Trazadone was prescribed by my PCP for sleep disturbances, including sleep paralysis. I was also using KLONOPIN / CLONAZEPAM 1mg daily for unwarranted anxiety, for approximately 6 weeks prior to the addition of Trazadone, as prescribed by my PCP.

    I was forced to quit the following 3 medications 'cold turkey' / immediately: Trazadone, Clonazepam & Tramadol. I experienced screaming nightmares, convulsions and hallucinations. It was like living in a dark parallel universe to say the least.

    While taking the Trazadone I experienced horrific hallucinations, delusions, hypermania, SEVERE CONFUSION (I asked my own husband who he was), SEVERE AND TOTAL LOSS OF APPETITE. I have lost 20 lbs within 2 weeks. My bowels are nearly destroyed as a a result of this issue. I am struggling to ingest healthy foods. Today it took me 2 hours to eat an apple. It has been 12 days since my last 'normal' BM.

    Also I experienced SEVERE WORSENING SWELLING of (bilateral) ankles and feet, as well as SEVERE NECK PAIN AND STIFFNESS that did not previously exist. The neck pain persists after 9 days of discontinuation, it is SEVERE, 10+ on the pain scale, nothing, ice or heat, ibuprofen or naproxen, is relieving it at all. (I am crying as I type this report. I am writing this report to warn others.)

    Due to bowel pain, lower right quadrant, of which I suspected appendicitis, I was once again in the ER on Nov 19, 2014 where I was given an ABDOMINAL CT. The findings were negative in all regards.

    Bowel issues and SEVERE NECK PAIN/Stiffness ( C-spine feels like it is on fire) are persistent 9 days after discontinuing Trazadone.

    I am now only taking Levothyroxine (hypothyroidism), Prozac 40mg and Tramadol PRN.

    I have done extensive web searches regarding Trazadone in order to educate myself regarding it's deadly dangers. In particular, if taken with ULTRAM/Tramadol it can cause 🌀 SEROTONIN SYNDROME, 🌀 to which I have drawn the conclusion I experienced and was fortunate to survive.

    (As it turns out it is CONTRAINDICATED with the occasional Tramadol 50mg I use for diagnosed back pain.) it is also CONTRAINDICATED for females over age 60 in which it has caused known brain injury in at least 70 reported cases according to my research.

    I will be informing a psychiatrist I was ordered to see and my PCP within the forthcoming 2 weeks., Nov 24th and Dec 8th respectively, of my unfortunate experience. I have added Trazadone to my medical allergies list to insure my own safety.


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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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