Review: could Niacin cause Rhabdomyolysis?
Summary: Rhabdomyolysis is found among people who take Niacin, especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months, also take medication Simvastatin, and have High blood cholesterol.
We study 5,770 people who have side effects while taking Niacin from FDA and social media. Among them, 142 have Rhabdomyolysis. Find out below who they are, when they have Rhabdomyolysis and more.
You are not alone: join a mobile support group for people who take Niacin and have Rhabdomyolysis >>>
Niacin has active ingredients of niacin. It is often used in high blood cholesterol. (latest outcomes from 6,316 Niacin users)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down) has been reported by people with high blood cholesterol, hyperlipidaemia, high blood pressure, depression, ill-defined disorder. (latest reports from 34,107 Rhabdomyolysis patients)
On Mar, 2, 2015: 5,769 people reported to have side effects when taking Niacin. Among them, 142 people (2.46%) have Rhabdomyolysis.
Time on Niacin when people have Rhabdomyolysis * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
Gender of people who have Rhabdomyolysis when taking Niacin * :
Age of people who have Rhabdomyolysis when taking Niacin * :
Severity of Rhabdomyolysis when taking Niacin ** :
How people recovered from Rhabdomyolysis ** :
Top conditions involved for these people * :
- Blood cholesterol increased (32 people, 22.54%)
- Hyperlipidaemia (24 people, 16.90%)
- Hypercholesterolaemia (10 people, 7.04%)
- Hypertension (5 people, 3.52%)
- Post herpetic neuralgia (3 people, 2.11%)
Top co-used drugs for these people * :
- Simvastatin (40 people, 28.17%)
- Baycol (33 people, 23.24%)
- Zocor (32 people, 22.54%)
- Aspirin (23 people, 16.20%)
- Bezafibrate (21 people, 14.79%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
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Could your condition cause:
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More questions for: Niacin, Rhabdomyolysis
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- Lyrica caused my kidneys to shut down
I was on Lyrica for 6 weeks and it almost killed me. I was so weak at the end that my daughter had to help me get out of bed go to the bathroom. I gained 22 lbs in 10 days. I gained over 40 lbs in 6 weeks. My ankles and feet were so swollen that the skin was starting to break open. I was in and out of the hospital until one of the doctors realized that my muscle tissue was breaking down and causing my kidneys to shut down. I have permenant nerve damage and issues with my speech and memory. I could not even take care of my children. I had to have someone with me at all times. I still have issues with my kidneys and edema. I lose my train of thought have through a sentence. I can no longer do basic math in my head. This drug forever changed my life.
- Avelox with prednisone and nabumetome = disaster
I was prescribed that combination of drugs in January 2013 when I went to my family doctor with a bad chest congestion and painful knees. After starting on the drugs, I got a severely painful neck and thumb and noticed some tingling in my left foot. I took the whole course of the avelox and prednisone, though I discontinued the nabumetome. I kept getting weaker and weaker till I could hardly walk. I ended up in the emergency room and was first diagnosed with Rhabdomyolysis but rushed to a bigger hospital for further diagnosis and treatment. I was close to needing blood, my kidneys were shutting down and I could barely walk. I was so weak! My right hand and left foot went "to sleep" and still haven't woken up. ( as of October 2013)
After many, many tests, they came up with a tentative diagnosis of vasculitis and myositis.
Then I had a kidney biopsy which confirmed the vasculitis and I was immediately treated with chemotherapy -- cytoxin for 6 months.
IAlthough I do feel much better, I am still suffering and taking drugs for the vasculitis and I am told that I may go into remission, but it could flare up again anytime. I am convinced that it was the drug combination that caused all this. I had been feeling great and had a daily walking routine of walking 2 to 5 miles per day, and no other complaints.
The nephrologist did say that while it might be that the vasculitis was drug induced, it didn't matter because I have it and he's treating it and would be doing it this way no matter how I got it.
When I told my family doctor that I thought it was the drug combination that caused my problems, he seemed surprised and really no discussion. I told them to put it in my medical records to NEVER give me a flouroquinolone drug again.
Yesterday when I went for a blood test and urinalysis ( which I was doing biweekly, but now every 6 weeks), it showed that I have a UTI and guess what the family doctor called in a prescription for? Cipro!!!! And he knows I'm still on prednisone and have only 30% kidney function!!!!!!
While I am not a litigious person, this really makes me so upset!!! I don't have the money to try to sue, but if telling my story will help keep unsuspecting people from the horrible damage this has caused, I feel obligrdmtomspeak up. I have had a terrible year. And I'm still not okay. And the drugs 'm taking make me susceptible to other problems. I'm still all puffed up from the prednisone. A couple of weeks ago I decided to try going for walks again, hopefully to lose some of this weight and build up my strength. It is so hard for me and my left foot hurts so bad. My legs feel so heavy it is a real struggle to walk a mile. But at least I can. When I was at my sickest, could barely walk to the bathroom and I could not get up from the toilet without using my arms to pull myself up. I couldn't go up the two steps to get into my house without help. I couldn't go upstairs to my bedroom for months.
More reviews for: Niacin, Rhabdomyolysis
Comments from related studies:
From this study (3 years ago):
Mohan Lakhani, MD on Jun, 9, 2012:
The combination therapy increases the likelyhood of rhabdo. Simvastatin at 80MG is ill advised because this dose also causes an inreased propensity for rhabdo. Infact FDA has issued a blavk box warning on that dose unless its a dose you have taken chronically.
Adding Niacin to a statin has not been shown to be of benefit based on the AIM HIGH trail that looked at statin ans niacin combination.
It may be reasonable to try statin therapy alone only (withouy statins or fibrate drugs) under medical supervision. Greater preferencr should be given to a water soluable drug
Mel on May, 22, 2012:
I am a 55 year caucasion female with hyperlipidaemia/dyslipidaemia. I was on statin drugs for over 10 years with no complications (Crestor, Simvastatin). After genetic testing revealed high risk factors, my doctor increased my Simvastatin to 80 mg. I took this dose for a year with no problems then added Niaspan 1000 twice a day. Several weeks later I was hospitalized with rhabdomyolysis. My CPK and liver enzymes were off the chart for 3 days. I recovered successfully after one week with no kidney damage. I was fortunate. My doctor says I can never take the statin drugs again but wants me to continue the Niaspan at 500 twice a day. I am not sure if it was the Simvastatin or the Niaspan that caused it but I believe it was likely the combination of high dose statin and niacin that triggered the condition. I am not sure that it is safe to take Niacin now.
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