Review: could Niacin cause Rhabdomyolysis?
Summary: Rhabdomyolysis is found among people who take Niacin, especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months, also take medication Simvastatin, and have High blood cholesterol. We study 5,774 people who have side effects while taking Niacin from FDA and social media. Among them, 142 have Rhabdomyolysis. Find out below who they are, when they have Rhabdomyolysis and more.
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Niacin has active ingredients of niacin. It is often used in high blood cholesterol. (latest outcomes from 6,319 Niacin users)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down) has been reported by people with high blood cholesterol, hyperlipidaemia, high blood pressure, depression, ill-defined disorder. (latest reports from 34,107 Rhabdomyolysis patients)
On May, 3, 2015: 5,771 people reported to have side effects when taking Niacin. Among them, 142 people (2.46%) have Rhabdomyolysis.
Time on Niacin when people have Rhabdomyolysis * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
Gender of people who have Rhabdomyolysis when taking Niacin * :
Age of people who have Rhabdomyolysis when taking Niacin * :
Severity of Rhabdomyolysis when taking Niacin ** :
How people recovered from Rhabdomyolysis ** :
Top conditions involved for these people * :
- Blood cholesterol increased (32 people, 22.54%)
- Hyperlipidaemia (24 people, 16.90%)
- Hypercholesterolaemia (10 people, 7.04%)
- Hypertension (5 people, 3.52%)
- Post herpetic neuralgia (3 people, 2.11%)
Top co-used drugs for these people * :
- Simvastatin (40 people, 28.17%)
- Baycol (33 people, 23.24%)
- Zocor (32 people, 22.54%)
- Aspirin (23 people, 16.20%)
- Bezafibrate (21 people, 14.79%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
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Comments from related studies:
From this study (3 years ago):
Mohan Lakhani, MD on Jun, 9, 2012:
The combination therapy increases the likelyhood of rhabdo. Simvastatin at 80MG is ill advised because this dose also causes an inreased propensity for rhabdo. Infact FDA has issued a blavk box warning on that dose unless its a dose you have taken chronically.
Adding Niacin to a statin has not been shown to be of benefit based on the AIM HIGH trail that looked at statin ans niacin combination.
It may be reasonable to try statin therapy alone only (withouy statins or fibrate drugs) under medical supervision. Greater preferencr should be given to a water soluable drug
Mel on May, 22, 2012:
I am a 55 year caucasion female with hyperlipidaemia/dyslipidaemia. I was on statin drugs for over 10 years with no complications (Crestor, Simvastatin). After genetic testing revealed high risk factors, my doctor increased my Simvastatin to 80 mg. I took this dose for a year with no problems then added Niaspan 1000 twice a day. Several weeks later I was hospitalized with rhabdomyolysis. My CPK and liver enzymes were off the chart for 3 days. I recovered successfully after one week with no kidney damage. I was fortunate. My doctor says I can never take the statin drugs again but wants me to continue the Niaspan at 500 twice a day. I am not sure if it was the Simvastatin or the Niaspan that caused it but I believe it was likely the combination of high dose statin and niacin that triggered the condition. I am not sure that it is safe to take Niacin now.
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