Review: could Omeprazole cause Fluid Retention?


Fluid retention is found among people who take Omeprazole, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Furosemide, and have Hypertension . We study 107,700 people who have side effects while taking Omeprazole from FDA and social media. Among them, 327 have Fluid retention. Find out below who they are, when they have Fluid retention and more.

You are not alone

Join a support group for people who take Omeprazole and have Fluid retention >>>

Personalized health information

On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 86 million people have used us. 300+ peer-reviewed medical journals have referenced our original studies. Start now >>>


Omeprazole has active ingredients of omeprazole. It is often used in gastrooesophageal reflux disease. (latest outcomes from Omeprazole 112,454 users)

Fluid Retention

Fluid retention (an abnormal accumulation of fluid in the blood) has been reported by people with breathing difficulty, pain, weakness, diarrhea, fatigue (latest reports from 23,045 Fluid retention patients).

On Aug, 28, 2016

107,700 people reported to have side effects when taking Omeprazole.
Among them, 327 people (0.3%) have Fluid Retention

Number of reports submitted per year:

Could Omeprazole cause Fluid retention?

Time on Omeprazole when people have Fluid Retention *:

  • < 1 month: 57.69 %
  • 1 - 6 months: 7.69 %
  • 6 - 12 months: 15.38 %
  • 1 - 2 years: 11.54 %
  • 2 - 5 years: 3.85 %
  • 5 - 10 years: 3.85 %
  • 10+ years: 0.0 %

Gender of people who have Fluid Retention when taking Omeprazole *:

  • female: 62.58 %
  • male: 37.42 %

Age of people who have Fluid Retention when taking Omeprazole *:

  • 0-1: 0.0 %
  • 2-9: 0.71 %
  • 10-19: 1.06 %
  • 20-29: 2.47 %
  • 30-39: 4.24 %
  • 40-49: 11.31 %
  • 50-59: 13.78 %
  • 60+: 66.43 %

Severity if Fluid Retention when taking Omeprazole **:

  • least: 16.67 %
  • moderate: 50.0 %
  • severe: 33.33 %
  • most severe: 0.0 %

How people recovered from Fluid Retention **:

  • while on drug: 0.0 %
  • after off the drug: 0.0 %
  • not yet: 100 %

Top conditions involved for these people *:

  • Hypertension (41 people)
  • Prophylaxis (37 people)
  • Gastrooesophageal Reflux Disease (27 people)
  • Depression (27 people)
  • Pain (23 people)

Top co-used drugs for these people *:

  • Furosemide (70 people)
  • Lasix (40 people)
  • Aspirin (37 people)
  • Allopurinol (34 people)
  • Prednisone (33 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Fluid retention when taking Omeprazole?

Browse all side effects of Omeprazole

a b c d e f g h i j k l m n o p q r s t u v w x y z

Drugs that are associated with Fluid retention

Fluid retention

Could your condition cause Fluid retention

Fluid retention

Can you answer these questions?

More questions for: Omeprazole, Fluid retention

You may be interested in these reviews

More reviews for: Omeprazole, Fluid retention

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.