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Review: could Omeprazole cause High blood sugar?

Summary: High blood sugar could be caused by Omeprazole, especially for people who are male, 60+ old, have been taking the drug for < 1 month, also take Aspirin, and have Multiple myeloma.

We study 89,577 people who have side effects while taking Omeprazole from FDA and social media. Among them, 407 have High blood sugar. Find out below who they are, when they have High blood sugar and more.

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Omeprazole (latest outcomes from 92,443 users) has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease.

High blood sugar

High blood sugar (high blood sugar) (latest reports from 141,911 patients) has been reported by people with high blood pressure, type 2 diabetes, diabetes, depression, bipolar disorder.

On Apr, 15, 2014: 89,577 people reported to have side effects when taking Omeprazole. Among them, 407 people (0.45%) have High Blood Sugar. They amount to 0.29% of all the 140,543 people who have High Blood Sugar on eHealthMe.

Trend of High blood sugar in Omeprazole reports

Time on Omeprazole when people have High blood sugar * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
High blood sugar50.00%11.36%6.82%4.55%11.36%11.36%4.55%

Gender of people who have High blood sugar when taking Omeprazole * :

High blood sugar40.68%59.32%

Age of people who have High blood sugar when taking Omeprazole * :

High blood sugar0.00%0.27%0.81%1.08%3.24%12.70%18.92%62.97%

Severity of High blood sugar when taking Omeprazole ** :

leastmoderateseveremost severe
High blood sugar16.67%50.00%16.67%16.67%

How people recovered from High blood sugar ** :

while on the drugafter off the drugnot yet
High blood sugar0.00%20.00%80.00%

Top conditions involved for these people * :

  1. Multiple myeloma (53 people, 13.02%)
  2. Hypertension (51 people, 12.53%)
  3. Prophylaxis (39 people, 9.58%)
  4. Type 2 diabetes mellitus (32 people, 7.86%)
  5. Insomnia (25 people, 6.14%)

Top co-used drugs for these people * :

  1. Aspirin (101 people, 24.82%)
  2. Furosemide (70 people, 17.20%)
  3. Lasix (70 people, 17.20%)
  4. Dexamethasone (66 people, 16.22%)
  5. Aredia (59 people, 14.50%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Omeprazole, High blood sugar

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On eHealthMe, Omeprazole (omeprazole) is often used for gastroesophageal reflux disease. Find out below the conditions Omeprazole is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Omeprazole used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (2 years ago):

  • Am I having a drug interaction which is causing my blood sugars to rise? My blood sugar 2 hrs ago was 459.


  • From this study (2 years ago):

  • I have been on Lisinopril for high blood pressure for 25 years, no problems. About 15 years ago I began having problems with reflux. I took Aciphex for about 6 years and the problem went away. 3 years ago I had to begin treatment for reflux again, this time with Prilosec OTC. I took it for about 6 months and was able to stop again. I had to have two stents in my heart 20 months ago (blockage only, no heart attack) and was on Plavix for 6 very long months. I am still having issues with internal bleeding even after stopping the Plavix. Dr put me on Omeprazole while I was still on the Plavix. About 6 months after starting the Omeprazole my doctor announced that I had type 2 diabetes, which floored me. He put me on Metformin and I began battling high glucose levels. About 6 months ago, I stopped taking the Omeprazole and my sugar levels went down significantly, even to the point that I could stop my medication (while limiting sugar and carbs). I started back on the Omeprazole three weeks ago, and my sugar has skyrocketed again. I am back on the full dose of Metformin (1500 mg a day), but my sugar ranges from 120 after fasting to 260 at peak times. I am looking for an alternative to the Omeprazole, and I am certain it was at least partly responsible for my developement of type 2 Diabetes. I wonder how many others this has happened to. The sad thing is that the Doctors don't have a clue about any of this.


  • From this study (4 years ago):

  • trace amounts of blood in urine; Dr. prescribed Cipro antibiotic, blood sugar high (173) from normal of 114-120. I'm a Type II Diabetic


Can you answer these questions (what is this?):

More questions for: Omeprazole, High blood sugar

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More reviews for: Omeprazole, High blood sugar

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Related study

- Omeprazole side effects


Related symptom

- High Blood Sugar



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