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Review: could Percocet cause Serotonin syndrome?

We study 24,247 people who have side effects while taking Percocet from FDA and social media. Among them, 23 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

Stay connected: join a mobile support group for people who take Percocet and have Serotonin syndrome >>>

Percocet

Percocet (latest outcomes from 26,398 users) has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain.

Serotonin syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) (latest reports from 34,500 patients) has been reported by people with depression, pain, stress and anxiety, major depression, bipolar disorder.

On Jul, 13, 2014: 24,239 people reported to have side effects when taking Percocet. Among them, 23 people (0.09%) have Serotonin Syndrome. They amount to 0.07% of all the 34,494 people who have Serotonin Syndrome on eHealthMe.

Trend of Serotonin syndrome in Percocet reports

Time on Percocet when people have Serotonin syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Serotonin syndrome0.00%100.00%0.00%0.00%0.00%0.00%0.00%

Age of people who have Serotonin syndrome when taking Percocet * :

0-12-910-1920-2930-3940-4950-5960+
Serotonin syndrome0.00%0.00%0.00%20.00%8.00%16.00%28.00%28.00%

Severity of Serotonin syndrome when taking Percocet ** :

leastmoderateseveremost severe
Serotonin syndrome0.00%0.00%0.00%100.00%

How people recovered from Serotonin syndrome ** :

n/a

Top conditions involved for these people * :

  1. Depression (11 people, 47.83%)
  2. Fibromyalgia (6 people, 26.09%)
  3. Anxiety (6 people, 26.09%)
  4. Pain (5 people, 21.74%)
  5. Insomnia (4 people, 17.39%)

Top co-used drugs for these people * :

  1. Clonazepam (7 people, 30.43%)
  2. Norvasc (7 people, 30.43%)
  3. Chantix (5 people, 21.74%)
  4. Amitriptyline hcl (5 people, 21.74%)
  5. Zoloft (5 people, 21.74%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Percocet and have Serotonin Syndrome
- group for people who take Percocet
- group for people who have Serotonin Syndrome

Comments from related studies:

  • From this study (1 week ago):

  • I've been diagnosed with sero-negative rheumatoid arthritis. I have only tested minimally positive on the anti-CCP test and had a slightly high SED rate. My most recent tests showed some slight elevation in some RA marker tests, but nothing really significant. My rheumatologist is now doubting whether I have RA or some other pain syndrome going on.

    Reply

    IHateRA on Jul, 22, 2014:

    My first RA Dr. put me on Plaquenil, it seemed to work for six months, then stopped - I thought the dose would be adjusted but it wasn't, so I went to another RA Doc - C-RP wasn't too high, sero neg. Was put on methotrexate - I ended up with a mouth sore the NEXT day, then bumps started appearing on my face, like zits, but NOT zits. I didn't touch them, but they ulcerated, left me full of scars on face, legs, etc - I have been OFF methotrexate for 5 years AND still have the same problem along with a daily fever (100+) and severe sweating - I knew the bumps were a sign of being allergic to Methotrexate, I quit it right away, called Dr. to get in - they told me 3 months (I was an established patient). In terms of fever and sweating, the ONLY thing I have in common with some of these posts and drug lists is METHOTREXATE - I wouldn't allow a pet to take it. I seem to have more in common with a friend who as MS - but my reg. doc doesn't listen to that. I can't take bio. drugs (live in "fungal" region), so I take pain medicine - as little as possible, I guess the Methotrexate is STILL messing with my body. I have a very good acupuncturist - when I told him that my Doc. wasn't "sure" about RA, he poked me (lightly) with his finger in two places and ask which hurt more. He confirmed the RA as it travels on certain meridians in Chinese medicine. Had I picked a different spot for hurting more, then we would have to figure out what I really had. My joints are deteriorating but now I'm afraid of the drugs for RA, so I just put up with and manage the pain (which is extreme) with pain meds, cold therapy (I love my cryo-cuff), and acupuncture. I wish that the side effects of RA drugs weren't as bad as they are! Leaving Cymbalta, Lyrica, Plaquenil and Methotrexate (all at different times) OUT of my body made me realize that they did affect me - I was "foggy" and sluggish mentally but didn't really notice it until I quit them.

    Reply

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Can you answer these questions (what is this?):

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    I took Percocet for pain for one week after rotator cuff surgery. My vision was blurred shortly after I began taking it, but I've been off of it for three weeks with no improvement in my vision. How long does this condition normally last?

  • Does gravol leave a sick sweet taste in your mouth?
    I just had an appendectomy and am on percocet and gravol. I have this disgusting sweet taste in my mouth that I can not get rid of with brushing my teeth and I'd like to know if this is a side effect of either of these drugs

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On eHealthMe, Percocet (acetaminophen; oxycodone hydrochloride) is often used for pain. Find out below the conditions Percocet is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

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