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Review: could Plaquenil cause Serum sickness?

Summary: Serum sickness is found among people who take Plaquenil, especially for people who are female, 60+ old, also take medication Prednisone, and have Rheumatoid arthritis.

We study 14,750 people who have side effects while taking Plaquenil from FDA and social media. Among them, 22 have Serum sickness. Find out below who they are, when they have Serum sickness and more.

You are not alone: join a support group for people who take Plaquenil and have Serum sickness >>>



Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in rheumatoid arthritis. (latest outcomes from 15,559 Plaquenil users)

Serum sickness

Serum sickness (hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum) has been reported by people with crohn's disease, asthma, rheumatoid arthritis, premedication, kidney transplant. (latest reports from 1,916 Serum sickness patients)

On Apr, 19, 2015: 14,744 people reported to have side effects when taking Plaquenil. Among them, 22 people (0.15%) have Serum Sickness.

Trend of Serum sickness in Plaquenil reports

Time on Plaquenil when people have Serum sickness * :


Gender of people who have Serum sickness when taking Plaquenil * :

Serum sickness75.00%25.00%

Age of people who have Serum sickness when taking Plaquenil * :

Serum sickness0.00%0.00%8.70%8.70%8.70%8.70%26.09%39.13%

Severity of Serum sickness when taking Plaquenil ** :


How people recovered from Serum sickness ** :


Top conditions involved for these people * :

  1. Rheumatoid arthritis (10 people, 45.45%)
  2. Hypokalaemia (4 people, 18.18%)
  3. Sjogren's syndrome (2 people, 9.09%)
  4. Multiple myeloma (2 people, 9.09%)
  5. Lupus nephritis (2 people, 9.09%)

Top co-used drugs for these people * :

  1. Prednisone (9 people, 40.91%)
  2. Hydrochlorothiazide (6 people, 27.27%)
  3. Remicade (6 people, 27.27%)
  4. Mabthera (6 people, 27.27%)
  5. Dexamethasone (6 people, 27.27%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of plaquenil and serum sickness on

Do you have Serum Sickness while taking Plaquenil?




You are not alone! Join a support group on :
- support group for people who take Plaquenil and have Serum Sickness
- support group for people who take Plaquenil
- support group for people who have Serum Sickness

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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