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Review: could Plaquenil cause Shortness of breath (Breathing difficulty)?

Summary: Shortness of breath is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years, also take medication Methotrexate, and have Rheumatoid arthritis.

We study 14,723 people who have side effects while taking Plaquenil from FDA and social media. Among them, 732 have Shortness of breath. Find out below who they are, when they have Shortness of breath and more.

You are not alone: join a mobile support group for people who take Plaquenil and have Shortness of breath >>>

 

 

 

 

Plaquenil

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in rheumatoid arthritis. (latest outcomes from 15,529 Plaquenil users)

Shortness of breath

Shortness of breath has been reported by people with high blood pressure, asthma, rheumatoid arthritis, pain, chronic obstructive pulmonary disease. (latest reports from 165,355 Shortness of breath patients)

On Dec, 29, 2014: 14,712 people reported to have side effects when taking Plaquenil. Among them, 596 people (4.05%) have Shortness Of Breath.

Trend of Shortness of breath in Plaquenil reports

Time on Plaquenil when people have Shortness of breath * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Shortness of breath12.28%15.79%10.53%31.58%8.77%14.04%7.02%

Gender of people who have Shortness of breath when taking Plaquenil * :

FemaleMale
Shortness of breath83.75%16.25%

Age of people who have Shortness of breath when taking Plaquenil * :

0-12-910-1920-2930-3940-4950-5960+
Shortness of breath0.00%0.38%0.38%6.26%6.64%17.46%27.70%41.18%

Severity of Shortness of breath when taking Plaquenil ** :

leastmoderateseveremost severe
Shortness of breath15.38%69.23%15.38%0.00%

How people recovered from Shortness of breath ** :

while on the drugafter off the drugnot yet
Shortness of breath0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (252 people, 42.28%)
  2. Systemic lupus erythematosus (74 people, 12.42%)
  3. Osteoporosis (49 people, 8.22%)
  4. Hypertension (47 people, 7.89%)
  5. Pain (27 people, 4.53%)

Top co-used drugs for these people * :

  1. Methotrexate (157 people, 26.34%)
  2. Prednisone (152 people, 25.50%)
  3. Folic acid (115 people, 19.30%)
  4. Humira (89 people, 14.93%)
  5. Enbrel (89 people, 14.93%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Shortness Of Breath while taking Plaquenil?

You are not alone! Join a mobile support group:
- support group for people who take Plaquenil and have Shortness Of Breath
- support group for people who take Plaquenil
- support group for people who have Shortness Of Breath

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    I am a pharmacy student in his final year on rotation at the VA Memorial Hospital. While working up a patient I noticed she has called many times complaining of "panic attacks" stating that she can't breath and has chest tightness. Over the previous two week I also noticed she has been to the ER for these same symptoms.

    Patient is a 61 year old female, with history of hypertension, dyslipidemia, migraine without aura, and while I don't see a specific diagnosis the patient current has a script for albuterol and at one time had a script for ipratropium. Patient has been a lifelone smoker who quit this past June.

    This patient was diagnosed with migraine headaches in 1986 and has been on propranolol 80mg ever since - 28 years. Interestingly, 1986 was around the time Inderal lost its patent and propranolol became generic.

    The patient served in the army from 1972-1976 during the vietnam war. She has a history of mental health issues (not sure what) and anxiety. I feel she has been "labeled" and current episodes of "panic attacks" are answered with benzodiazapines and she is sent on her way.

    During my first look into propranolol, the very first page said, "Check with your doctor immediately if you have any of the following side effects:
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    This caught my attention. I then started probing deeper and found an article written by Dr. Noreen Kassem titled "The Long Term Side Effects of Propranolol." In the article she wrote, "...propranolol and other beta blockers can also worsen breathing disorders, such as emphysema and asthma, because they constrict the air passageways of the lungs and can cause fluid build-up in the lungs. This can result in shortness of breath, difficulty breathing and chest tightness in patients who are on propranolol for long periods of time, or who have respiratory disorders."

    I tried to find Dr. Kassem to no avail. I wanted to know exactly where she got this information. I would like to find some primary literature on this topic but haven't had any luck. I need proof, because as of right now I'm a student being told that "she has been on this agent for 28 years, I doubt it's bothering her now." I'm not buying it and I think something is here.

    -61 year olf lifelone smoker with almost guaranteed declining lung function
    -28 year (chronic) use of propranlol (a non-selective beta blocker)
    -Possible asthmatic
    -Experiencing "shortness of breath" and "Chest tightness" that she and everyone else is called anxiety and/or panic attacks.

    I think the propranolol, while not the cause of these problems, is certainly exacerbating them. Does anyone have proof of this happening; peer reviewed articles, anything. My rotation is done in 2 weeks and I know no one will ever look into this again after I'm gone.

    ps... forgive any typos
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