Plaquenil and Withdrawal syndrome - from FDA reports


Withdrawal syndrome is found among people who take Plaquenil, especially for people who are female, 50-59 old also take medication Lyrica, and have Fibromyalgia. This review analyzes which people have Withdrawal syndrome with Plaquenil. It is created by eHealthMe based on reports of 29,662 people who have side effects when taking Plaquenil from FDA, and is updated regularly.

What to expect?

If you take Plaquenil and have Withdrawal syndrome, find out what symptoms you could have in 1 year or longer.

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On Apr, 24, 2017

29,662 people reported to have side effects when taking Plaquenil.
Among them, 34 people (0.11%) have Withdrawal Syndrome

Number of reports submitted per year:

Could Plaquenil cause Withdrawal syndrome?

Gender of people who have Withdrawal Syndrome when taking Plaquenil *:

  • female: 93.94 %
  • male: 6.06 %

Age of people who have Withdrawal Syndrome when taking Plaquenil *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 3.7 %
  • 30-39: 18.52 %
  • 40-49: 18.52 %
  • 50-59: 48.15 %
  • 60+: 11.11 %

Top conditions involved for these people *:

  • Fibromyalgia (15 people, 44.12%)
  • Rheumatoid Arthritis (12 people, 35.29%)
  • Systemic Lupus Erythematosus (8 people, 23.53%)
  • Sleep Disorder (5 people, 14.71%)
  • Pain (5 people, 14.71%)

Top co-used drugs for these people *:

  • Lyrica (13 people, 38.24%)
  • Cymbalta (10 people, 29.41%)
  • Synthroid (7 people, 20.59%)
  • Enbrel (6 people, 17.65%)
  • Flexeril (5 people, 14.71%)

Top other side effects for these people *:

  • Drug Ineffective (13 people, 38.24%)
  • Nausea And Vomiting (12 people, 35.29%)
  • Weight Increased (10 people, 29.41%)
  • Pain (9 people, 26.47%)
  • Feeling Abnormal (9 people, 26.47%)

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Withdrawal syndrome when taking Plaquenil?


Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. (latest outcomes from Plaquenil 31,546 users)

Withdrawal Syndrome

Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) has been reported by people with depression, pain, stress and anxiety, back pain, fibromyalgia (latest reports from 15,159 Withdrawal syndrome patients).

Browse all side effects of Plaquenil

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Drugs that are associated with Withdrawal syndrome

Withdrawal syndrome

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What would happen?

Forecast new side effects and undetected conditions when you take Plaquenil and have Withdrawal syndrome.

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