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Review: could Prednisone cause Knee joint replacement?

Summary: Knee joint replacement is found among people who take Prednisone, especially for people who are female, 60+ old, also take medication Methotrexate, and have Rheumatoid arthritis.

We study 146,809 people who have side effects while taking Prednisone from FDA and social media. Among them, 259 have Knee joint replacement. Find out below who they are, when they have Knee joint replacement and more.

You are not alone: join a support group for people who take Prednisone and have Knee joint replacement >>>



Prednisone has active ingredients of prednisone. It is often used in rheumatoid arthritis. (latest outcomes from 150,135 Prednisone users)

Knee joint replacement

Knee joint replacement has been reported by people with rheumatoid arthritis, multiple sclerosis, osteoporosis, high blood pressure, pain. (latest reports from 6,184 Knee joint replacement patients)

On Mar, 31, 2015: 146,809 people reported to have side effects when taking Prednisone. Among them, 259 people (0.18%) have Knee Joint Replacement.

Trend of Knee joint replacement in Prednisone reports

Time on Prednisone when people have Knee joint replacement * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Knee joint replacement0.00%0.00%0.00%0.00%0.00%0.00%100.00%

Gender of people who have Knee joint replacement when taking Prednisone * :

Knee joint replacement75.84%24.16%

Age of people who have Knee joint replacement when taking Prednisone * :

Knee joint replacement0.00%0.00%0.00%0.53%3.74%13.90%24.60%57.22%

Severity of Knee joint replacement when taking Prednisone ** :


How people recovered from Knee joint replacement ** :


Top conditions involved for these people * :

  1. Rheumatoid arthritis (133 people, 51.35%)
  2. Osteoporosis (33 people, 12.74%)
  3. Pain (24 people, 9.27%)
  4. Hypertension (23 people, 8.88%)
  5. Muscle spasms (12 people, 4.63%)

Top co-used drugs for these people * :

  1. Methotrexate (97 people, 37.45%)
  2. Prednisone tab (81 people, 31.27%)
  3. Enbrel (77 people, 29.73%)
  4. Humira (67 people, 25.87%)
  5. Folic acid (52 people, 20.08%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Knee Joint Replacement while taking Prednisone?




You are not alone! Join a mobile support group on :
- support group for people who take Prednisone and have Knee Joint Replacement
- support group for people who take Prednisone
- support group for people who have Knee Joint Replacement

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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