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Review: could Premarin cause Mood swings?

Summary: Mood swings could be caused by Premarin, especially for people who are female, 50-59 old, also take Provera, and have Hormone replacement therapy.

We study 69,829 people who have side effects while taking Premarin from FDA and social media. Among them, 227 have Mood swings. Find out below who they are, when they have Mood swings and more.

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Premarin (latest outcomes from 70,279 users) has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy.

Mood swings

Mood swings (an extreme or rapid change in mood) (latest reports from 119,690 patients) has been reported by people with quit smoking, depression, birth control, attention deficit hyperactivity disorder, pain.

On Apr, 11, 2014: 69,809 people reported to have side effects when taking Premarin. Among them, 227 people (0.33%) have Mood Swings. They amount to 0.19% of all the 119,395 people who have Mood Swings on eHealthMe.

Trend of Mood swings in Premarin reports

Time on Premarin when people have Mood swings * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Mood swings18.03%3.28%6.56%1.64%24.59%4.92%40.98%

Age of people who have Mood swings when taking Premarin * :

Mood swings0.00%0.00%0.00%2.25%3.60%31.08%32.88%30.18%

Severity of Mood swings when taking Premarin ** :

leastmoderateseveremost severe
Mood swings50.00%0.00%0.00%50.00%

How people recovered from Mood swings ** :


Top conditions involved for these people * :

  1. Hormone replacement therapy (29 people, 12.78%)
  2. Depression (23 people, 10.13%)
  3. Osteoporosis (20 people, 8.81%)
  4. Pain (17 people, 7.49%)
  5. Hypertension (15 people, 6.61%)

Top co-used drugs for these people * :

  1. Provera (32 people, 14.10%)
  2. Prempro (27 people, 11.89%)
  3. Klonopin (23 people, 10.13%)
  4. Aspirin (22 people, 9.69%)
  5. Prozac (20 people, 8.81%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Premarin, Mood swings

You can also:

On eHealthMe, Premarin (estrogens, conjugated) is often used for hormone replacement therapy. Find out below the conditions Premarin is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Premarin used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (2 years ago):

  • After moving 1000+ miles, and unable to find work for several months, I was no longer able to pay for Depakote or Premarin. Lack of Premarin sent me into menopause, with skin changes, insomnia, weight gain, etc. Without Depakote I had sever them I became increasingly depressed, lost interest in life, and then extremely agitated/hypomanic. After 2 weeks back on Depakote I felt like a new person, and began to find interest in life again.


Can you answer these questions (what is this?):

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Related study

- Premarin side effects


Related symptom

- Mood Swings



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