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Review: could Prempro cause Breast cancer?

Summary: Breast cancer is found among people who take Prempro, especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years, also take medication Premarin, and have Hormone replacement therapy.

We study 37,489 people who have side effects while taking Prempro from FDA and social media. Among them, 14,615 have Breast cancer. Find out below who they are, when they have Breast cancer and more.

You are not alone: join a mobile support group for people who take Prempro and have Breast cancer >>>






Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. (latest outcomes from 37,633 Prempro users)

Breast cancer

Breast cancer has been reported by people with hormone replacement therapy, multiple sclerosis, rheumatoid arthritis, menopausal symptoms, osteoporosis. (latest reports from 77,332 Breast cancer patients)

On Mar, 1, 2015: 37,489 people reported to have side effects when taking Prempro. Among them, 14,615 people (38.98%) have Breast Cancer.

Trend of Breast cancer in Prempro reports

Time on Prempro when people have Breast cancer * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Breast cancer0.55%2.44%3.78%12.28%35.88%33.57%11.49%

Age of people who have Breast cancer when taking Prempro * :

Breast cancer0.00%0.00%0.00%0.01%0.12%5.90%51.04%42.94%

Severity of Breast cancer when taking Prempro ** :


How people recovered from Breast cancer ** :


Top conditions involved for these people * :

  1. Hormone replacement therapy (7,440 people, 50.91%)
  2. Menopausal symptoms (975 people, 6.67%)
  3. Menopause (474 people, 3.24%)
  4. Hypertension (227 people, 1.55%)
  5. Hot flush (142 people, 0.97%)

Top co-used drugs for these people * :

  1. Premarin (9,602 people, 65.70%)
  2. Provera (8,537 people, 58.41%)
  3. Cycrin (1,849 people, 12.65%)
  4. Medroxyprogesterone acetate (1,702 people, 11.65%)
  5. Estrace (1,125 people, 7.70%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of prempro and breast cancer on

Do you have Breast Cancer while taking Prempro?

You are not alone! Join a mobile support group:
- support group for people who take Prempro and have Breast Cancer
- support group for people who take Prempro
- support group for people who have Breast Cancer

Drugs in real world that are associated with:

Could your condition cause:

Can you answer these questions (Ask a question):

  • My question is there are if studies and reports on the efficiency of this treatment?
    My mother is being treated against breast cancer for almost 20 years. There are about four years has been removed a breast and emptied (removed) the armpits. After she used only Xeloda Capecitabina 500 mg and soon after chemotherapy. At present she use Faslodex one time by month. Another doctor, suggested using the Faslodex and Xeloda Capecitabina 500 mg together. My question is there are if studies and reports on the efficiency of this treatment?
  • Prempro and post menapausel bleeding
    I am 46 years old. was taking birth control pills for 10 years. August of 2013 I stopped getting my periods. In January I saw my Gyn. He advised to wait another month and get blood work done. Results showed I was postmenapousal.
    Dr. put me on the lowest dose of Prempro. In 2 weeks I started heavy bleeding for about 18 days. Then in 3 weeks started bleeding again, Stopped in 15 days and then started again in 10 days. Then did not bleed for 5 weeks and then again. Spoke to the dr. increased the dose to the highest level and did a biopsy. Results the linning was too thin. I am on this higher dose for two months. Started bleeding in 2 weeks and lasted for 5 days. Not heavy at all. I could live with it. Then in 30 days started bleeding again. I am now bleeding for 14 days and don't know whats next. Any suggests on what I should except or what I should do next. PLEASE HELP.
  • Does femara affect crp results?
    Does femara affect the results of the C Reactive Protein test? I have been on it for two years and have side effects of joint pain and hot flashes with nausea.
  • Breast cancer of former norplant users (2 answers)
    Patients who had a norplant that developed breast cancer after it's removal. I know of 3 young women who have aggressive breast cancer and they all had norplant at some point.
  • Can i take garcinia cambogia with 80mg of flouoxitine and prempro?
    Would like to know if I can take Garcinia Cambogia with the meds and vitamin I am currently taking. I'd like to lose weight with Garcinia Cambogia. Thank You

More questions for: Prempro, Breast cancer

You may be interested at these reviews (Write a review):

  • Victoza and breast cancer
    I took victoza for about 1 year. I have no history of breast cancer 9 my family.
  • I'm curing my lichen sclerosis
    I took Prempro for about 5 years and then Activella for about 3 years for Menopausal symptoms. My first obvious symptoms of a problem began in 2005 which follow all the classic symptoms of Lichen. I spent thousands on Urology exams, tests, and surgical procedures. And thousands on Gynecological attempts at remedies. Finally with no answers and no relief against the doctors advise I went off my H.R.T.s and Vagifem and then a year later all antiobiotics, creams etc. and though mending has been catastrophically slow (4 years)I am in what I'd call the last stage of mending as this condition is not just skin deep (urogenital). I have just the faintest redness left (where it first began!)and of course scarring/fusing of labia's etc. But I would say 90% of symptoms are gone. Just know it took 4 Years to heal without pain medications and all the crazy meds that just covered the 'adverse chemical reaction'. I filed a report with the FDA in 2009 and of course heard nothing back.

More reviews for: Prempro, Breast cancer

Comments from related studies:

  • From this study (4 years ago):

  • Judy on Jul, 4, 2011:

    I have been taking prometrium for two weeks now. It has helped reduce my headaches and I sleep so much better. The one negative thing I've noticed is my varicose veins in the back of my calf are protruding more and are painful. They used to be painful when I was having periods or if I was on birth control pills, but I haven't had a period in two years now and the varicose veins didn't give me any problems. But now with the prometrium I'm feeling it again. Is it not safe for me to take prometrium because of the varicose veins?


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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