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Review: could Promethazine cause Serotonin syndrome?

Summary: Serotonin syndrome could be caused by Promethazine, especially for people who are female, 40-49 old, also take Tramadol hydrochloride, and have Fibromyalgia.

We study 601 people who have side effects while taking Promethazine from FDA and social media. Among them, 4 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

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Promethazine

Promethazine (latest outcomes from 1,201 users) has active ingredients of promethazine hydrochloride. It is often used in nausea.

Serotonin syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) (latest reports from 34,373 patients) has been reported by people with depression, pain, stress and anxiety, major depression, bipolar disorder.

On Apr, 12, 2014: 589 people reported to have side effects when taking Promethazine. Among them, 4 people (0.68%) have Serotonin Syndrome. They amount to 0.01% of all the 34,369 people who have Serotonin Syndrome on eHealthMe.

Trend of Serotonin syndrome in Promethazine reports

Time on Promethazine when people have Serotonin syndrome * :

n/a

Gender of people who have Serotonin syndrome when taking Promethazine * :

FemaleMale
Serotonin syndrome100.00%0.00%

Age of people who have Serotonin syndrome when taking Promethazine * :

0-12-910-1920-2930-3940-4950-5960+
Serotonin syndrome0.00%0.00%0.00%0.00%0.00%100.00%0.00%0.00%

Severity of Serotonin syndrome when taking Promethazine ** :

n/a

How people recovered from Serotonin syndrome ** :

n/a

Top conditions involved for these people * :

  1. Fibromyalgia (4 people, 100.00%)

Top co-used drugs for these people * :

  1. Tramadol hydrochloride (4 people, 100.00%)
  2. Savella (4 people, 100.00%)
  3. Lasix (4 people, 100.00%)
  4. Zestril (4 people, 100.00%)
  5. Aspirin (3 people, 75.00%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Promethazine, Serotonin syndrome

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On eHealthMe, Promethazine (promethazine hydrochloride) is often used for nausea. Find out below the conditions Promethazine is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Promethazine used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

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  • From this study (1 week ago):

  • Persistant vomiting. Been diagnosed with paralytic ileus thru gastric emptying study. Have a GI doc but am getting no releif from the constant vomiting malnutrition other than hospitalization until better. Sent home after a week sometimes 2. Only to become ill again weeks later. Have had CT MRI XRays. Any insight or advise?

    Reply

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More questions for: Promethazine, Serotonin syndrome

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