Promethazine and Serotonin syndrome - from FDA reports


Summary

Serotonin syndrome is found among people who take Promethazine, especially for people who are female, 50-59 old , have been taking the drug for < 1 month, also take medication Metformin, and have Pain. This review analyzes which people have Serotonin syndrome with Promethazine. It is created by eHealthMe based on reports of 9,009 people who have side effects when taking Promethazine from FDA , and is updated regularly.

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On Sep, 26, 2017

9,009 people reported to have side effects when taking Promethazine.
Among them, 49 people (0.54%) have Serotonin syndrome


Number of reports submitted per year:

Could Promethazine cause Serotonin syndrome?

Time on Promethazine when people have Serotonin syndrome *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Serotonin syndrome when taking Promethazine *:

  • female: 93.48 %
  • male: 6.52 %

Age of people who have Serotonin syndrome when taking Promethazine *:

  • 0-1: 0.0 %
  • 2-9: 6.98 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 4.65 %
  • 40-49: 34.88 %
  • 50-59: 39.53 %
  • 60+: 13.95 %

Top conditions involved for these people *:

  • Stress And Anxiety (12 people, 24.49%)
  • Pain (12 people, 24.49%)
  • Depression (10 people, 20.41%)
  • Schizophrenia (7 people, 14.29%)
  • Procedural Pain (7 people, 14.29%)

Top co-used drugs for these people *:

  • Metformin (16 people, 32.65%)
  • Ondansetron (15 people, 30.61%)
  • Morphine (12 people, 24.49%)
  • Clozapine (11 people, 22.45%)
  • Benadryl (10 people, 20.41%)

Top other side effects for these people *:

  • Agitation (11 people, 22.45%)
  • Pain (8 people, 16.33%)
  • Clonus (8 people, 16.33%)
  • Pollakiuria (6 people, 12.24%)
  • Fall (6 people, 12.24%)

* Approximation only. Some reports may have incomplete information.

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Serotonin syndrome and Promethazine from FDA and eHealthMe reports

Promethazine

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. (latest outcomes from Promethazine 9,862 users)

Serotonin syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) has been reported by people with depression, pain, stress and anxiety, major depression, insomnia (latest reports from 10,388 Serotonin syndrome patients).

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Serotonin syndrome

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