Review: could Propranolol hydrochloride cause Bipolar i disorder?
Summary: Bipolar i disorder is reported only by a few people who take Propranolol hydrochloride.
We study 2,508 people who have side effects while taking Propranolol hydrochloride from FDA and social media. Among them, 3 have Bipolar i disorder. Find out below who they are, when they have Bipolar i disorder and more.
You are not alone: join a mobile support group for people who take Propranolol hydrochloride and have Bipolar i disorder >>>
Propranolol hydrochloride has active ingredients of propranolol hydrochloride. It is often used in migraine. (latest outcomes from 3,334 Propranolol hydrochloride users)
Bipolar i disorder
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode) has been reported by people with depression, bipolar disorder, multiple sclerosis, pain, sleep disorder. (latest reports from 9,891 Bipolar i disorder patients)
On Jan, 20, 2015: 2,494 people reported to have side effects when taking Propranolol hydrochloride. Among them, 3 people (0.12%) have Bipolar I Disorder.
Time on Propranolol hydrochloride when people have Bipolar i disorder * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
|Bipolar i disorder||0.00%||0.00%||0.00%||100.00%||0.00%||0.00%||0.00% |
Gender of people who have Bipolar i disorder when taking Propranolol hydrochloride * :
|Bipolar i disorder||0.00%||100.00% |
Age of people who have Bipolar i disorder when taking Propranolol hydrochloride * :
|Bipolar i disorder||0.00%||0.00%||33.33%||0.00%||33.33%||0.00%||0.00%||33.33% |
Severity of Bipolar i disorder when taking Propranolol hydrochloride ** :
|least||moderate||severe||most severe |
|Bipolar i disorder||0.00%||0.00%||100.00%||0.00% |
How people recovered from Bipolar i disorder ** :
|while on the drug||after off the drug||not yet |
|Bipolar i disorder||0.00%||50.00%||50.00% |
Top conditions involved for these people * :
- Bipolar 1 (1 people, 33.33%)
- Unipolar depression (1 people, 33.33%)
- Tremor - essential (1 people, 33.33%)
- Muscle spasms (1 people, 33.33%)
- Tremor (1 people, 33.33%)
Top co-used drugs for these people * :
- Glipizide (1 people, 33.33%)
- Synthroid (1 people, 33.33%)
- Valium (1 people, 33.33%)
- Lithium carbonate (1 people, 33.33%)
- Quetiapine fumarate (1 people, 33.33%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
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Do you have Bipolar I Disorder while taking Propranolol Hydrochloride?
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- support group for people who have Bipolar I Disorder
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- Is there a published study that shows propranolol can cause shortness of breath and chest tightness?
I am a pharmacy student in his final year on rotation at the VA Memorial Hospital. While working up a patient I noticed she has called many times complaining of "panic attacks" stating that she can't breath and has chest tightness. Over the previous two week I also noticed she has been to the ER for these same symptoms.
Patient is a 61 year old female, with history of hypertension, dyslipidemia, migraine without aura, and while I don't see a specific diagnosis the patient current has a script for albuterol and at one time had a script for ipratropium. Patient has been a lifelone smoker who quit this past June.
This patient was diagnosed with migraine headaches in 1986 and has been on propranolol 80mg ever since - 28 years. Interestingly, 1986 was around the time Inderal lost its patent and propranolol became generic.
The patient served in the army from 1972-1976 during the vietnam war. She has a history of mental health issues (not sure what) and anxiety. I feel she has been "labeled" and current episodes of "panic attacks" are answered with benzodiazapines and she is sent on her way.
During my first look into propranolol, the very first page said, "Check with your doctor immediately if you have any of the following side effects:
1)Coughing up Mucus
2)Shortness of Breath
3)Tightness in the Chest"
This caught my attention. I then started probing deeper and found an article written by Dr. Noreen Kassem titled "The Long Term Side Effects of Propranolol." In the article she wrote, "...propranolol and other beta blockers can also worsen breathing disorders, such as emphysema and asthma, because they constrict the air passageways of the lungs and can cause fluid build-up in the lungs. This can result in shortness of breath, difficulty breathing and chest tightness in patients who are on propranolol for long periods of time, or who have respiratory disorders."
I tried to find Dr. Kassem to no avail. I wanted to know exactly where she got this information. I would like to find some primary literature on this topic but haven't had any luck. I need proof, because as of right now I'm a student being told that "she has been on this agent for 28 years, I doubt it's bothering her now." I'm not buying it and I think something is here.
-61 year olf lifelone smoker with almost guaranteed declining lung function
-28 year (chronic) use of propranlol (a non-selective beta blocker)
-Experiencing "shortness of breath" and "Chest tightness" that she and everyone else is called anxiety and/or panic attacks.
I think the propranolol, while not the cause of these problems, is certainly exacerbating them. Does anyone have proof of this happening; peer reviewed articles, anything. My rotation is done in 2 weeks and I know no one will ever look into this again after I'm gone.
ps... forgive any typos
- I am on propranolol 10mg 3tad i now have a stomach bug and have been prescribed vancomycin, is it safe to take both together
I have a very bad stomach bug, can this be caused by use propranolol, and is it safe and will the vancomycin work, while i am taken propranolol
- Should i go to the emergency room for severe leg pain. i'm taking propranlol (1 answer)
Extremely soar legs. Soar throat, swollen thyroid, and headache.;
- Propranolo & pregabalin - do they produce heart troubles? my meds mix has
Being on zopiclone 75mg (sleep med) gave me terrible poly/firbomyalgia, which I was then prescrbed pregabalin to aleviate pains and anxiety, and the propranolo to help with the same. On day one of propranolo I had a medium heart attack like event, within 24hrs had a large attack and became hospitalised. But vital signs and chest xray, blood tests, then showed 'normal'. But since then have had several more (almost one or more a month) heart attacklike events, hospitalisation, etc, but still being told all 'normal'. But now I've met someone who has told me they had similar heart issues and were told professionally for years his vital signs were normal : he now has a tripple-heart-bypass. I keep being told the angina like symtoms I have are anxiety realted - "only". But when I look at the professional descriptions and illustrations of angina, and similar, I see I could have written and drawn those from my own experiences. Hellish! No where to turn to. So I'm stopping the meds now one by one in careful withdrawl - docs don't like it - but I'm convinced my meds are slowly degrading my overall health as they build up into a toxic soup in me. I started this withdrawly after I discovered that - officially - Pregabalin (a calcium ?minimiser) and Propranolol (a beta blocker) should not be taken together in case they cause heart malfunctions... shame my doctors didn't know that.... before they let me take them for 8 months!!!!!!
More questions for: Propranolol hydrochloride, Bipolar i disorder
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- Transition from mirtazapine to cymbalta (bipolar ii) 6 week duration taken in conjunction with seroquel, propranalol and implanon
In early September I approached my Psychiatrist to report that I was having sleep paralysis episodes as well as insatiable appetite. I had put on about 20lb in the space of 6 months since the sleep paralysis started.
My Psychiatrist opted to wean me off the Mirtazapine and onto Cymbalta. I have now been on 60mg of Cymbalta for about 4 weeks and completely titrated off the Mirtazapine.
I have noted that since switching to Cymbalta that I no longer have the insatiable appetite, nor have I had any further sleep paralysis episodes (though I have had a brain MRI to rule out any physiological issues - yet to receive results).
I have noticed that I have had mild to moderate rolling nausea with the Cymbalta and that I now have food aversions. Food does not interest me as much anymore and I find that certain foods (mostly processed snacks) are no longer palatable. I also find that I become full after much smaller meal portions.
I have found that I can no longer drink wine or spirits because they now taste awful however I can still tolerate certain brands of beer. I also no longer enjoy drinking cola.
I am also on the Implanon Implant. I have had this implant inserted for about 12 months and my cycles have been rather regular. Since starting the Cymbalta I have had some breakthrough bleeding yet my periods have not been as painful, though they have been heavier and longer.
My Psychiatrist will commence titrating me off the Seroquel in about two weeks and onto Topamax as it is his belief it will be less sedating than the Seroquel and that it will hopefully help as a mood stabiliser, treat my migraines and allow me to come off the Propranolol. he also hopes that I am able to loose some of the weight gained since the sleep paralysis episodes started.
As a side note regarding the Propranolol, I have naturally low blood pressure and I find while Propranalol is generally an effective migraine prophylactic, (I do get some breakthrough migraines) it does make my blood pressure even lower which leads to dizziness and faintness when I stand up too quickly from a recumbent position.
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One year ago, after being on Lyrica for 5 years, I developed extreme tooth sensitivity. It came on very quickly to one tooth, then quickly spread to all of my top front 6 teeth and now the rest of my teeth are sensitive too. When I say sensitive, I mean that I can't even bite a banana using my front teeth!!! I ended up having root canals on my top front 4 teeth and then had to have two of them pulled because even after the root canals, they were extremely sensitive to any sort of touch at all!!! I now have implants for those two teeth and yet the sensitivity continues in the rest of my teeth. The dentist, endodontist, periodontist and family physician can find nothing 'physically' wrong. My gums are healthy. I feel that it is somehow nerve related and that there has been some damage done. I can not even form words properly because my tongue hits the back of my front teeth as I talk (which is normal), but even THAT causes me pain. I have to constantly use Tylenol and Advil (although they really don't give me any relief.) I have gone through no less than 20 tubes of Orajel and Ambesol in the past year. It is pretty much the only thing that gives me any sort of relief. It has completely affected my quality of life, (as if the reason I needed the Lyrica in the first place didn't already do that enough!!) I am confident that it is the Lyrica as I can find no other literature on the Propranolol causing any side effects such as this. I am a very fit, active lady. I happen to have P.O.T.S which is why I am on the Beta Blocker and Lyrica in the first place. I sure hope that if I stop taking the Lyrica, the sensitivity will decrease. At this rate, I'm going to lose all of my teeth! Incidentally, two of my otherwise healthy teeth now feel wiggly as well! Up until recently, I had only typical, age related dental issues. My dentist is perplexed as to what is going on with me. This is so frustrating!
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Comments from related studies:
From this study (6 months ago):
i'm pretty much the most comlex case 4 psychiatrists, 3 psychologists, a nuero scientist/adult mood disorder specialised doctor, 3 gp's, 2 naturopaths and an adhd specialist have ever come accross. i'm basically a pharmacy on legs with over 32types of medications tried in 13 months including those i've mentioned above. i admitted myself into hospital (to get a team around me) for 3 weeks in the psych ward in july 2013 but was granted an agreed by patient/all the different types of doctors and nursing staff to b words) and 'what planet am i from (using a nurses exact words) because i'm soe released early as they had 'no lollies left to try' (using the head psych's exact words referring to prescription medications) anr how so rediculously med-resistant to all that could be tried. the night nurses were actually scare d of me, not by any violence or anything at all alike, but by my uncanny ability to be dosed so very very highly on so many potent medications and extreme combinations to no avail. i've had 9ver 25 blood tests, ultrasounds, brain imagery mri's, sleep disorders studies in hospital and numerous other forms of clinical testing to still be on the rollercoaster and the viscous cycle 13months later and i'm still in the same boat! it's been said way more than just a few times that i'm one hell of a case for the record books!
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