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Review: could Prozac cause Irritability?

Summary: Irritability is found among people who take Prozac, especially for people who are female, 40-49 old, have been taking the drug for < 1 month, also take medication Xanax, and have Depression.

We study 39,027 people who have side effects while taking Prozac from FDA and social media. Among them, 507 have Irritability. Find out below who they are, when they have Irritability and more.

You are not alone: join a mobile support group for people who take Prozac and have Irritability >>>

 

 

 

 

Prozac

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. (latest outcomes from 42,333 Prozac users)

Irritability

Irritability has been reported by people with depression, quit smoking, pain, stress and anxiety, attention deficit hyperactivity disorder. (latest reports from 23,559 Irritability patients)

On Feb, 13, 2015: 39,027 people reported to have side effects when taking Prozac. Among them, 507 people (1.30%) have Irritability.

Trend of Irritability in Prozac reports

Time on Prozac when people have Irritability * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Irritability24.00%20.00%6.00%22.00%14.00%2.00%12.00%

Age of people who have Irritability when taking Prozac * :

0-12-910-1920-2930-3940-4950-5960+
Irritability1.13%1.81%8.80%9.71%16.48%33.18%19.64%9.26%

Severity of Irritability when taking Prozac ** :

leastmoderateseveremost severe
Irritability0.00%62.50%37.50%0.00%

How people recovered from Irritability ** :

while on the drugafter off the drugnot yet
Irritability0.00%25.00%75.00%

Top conditions involved for these people * :

  1. Depression (148 people, 29.19%)
  2. Pain (65 people, 12.82%)
  3. Anxiety (54 people, 10.65%)
  4. Bipolar disorder (35 people, 6.90%)
  5. Smoking cessation therapy (33 people, 6.51%)

Top co-used drugs for these people * :

  1. Xanax (85 people, 16.77%)
  2. Neurontin (69 people, 13.61%)
  3. Oxycontin (61 people, 12.03%)
  4. Seroquel (61 people, 12.03%)
  5. Ambien (59 people, 11.64%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of prozac and irritability on

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- support group for people who take Prozac and have Irritability
- support group for people who take Prozac
- support group for people who have Irritability

Drugs in real world that are associated with:

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Can you answer these questions (Ask a question):

  • I too have hashimoto's and hydrocephalus
    I have been HYPOTHYROID since at least 18 years old, now 43, and last 2 years found out that I did test positive for Hashimotos and was told I have no thyroid left. When I was 26, I had visual disturbance and went to the ER. Was told by the neurologist that I had mild hydroencephaly, and may require a shunt. Due to lack of insurance, went years with no treatment or follow up. Now have numerous problems with Hashimotos/Hypothyroid and investigating the correlation between the Hydroencephaly and Hashimotos. Is this the only study of the two relations?
  • Im taking prozac and about to go on testosterone cypionate at the same time what are the side effects of both of these together?
    I am a transgender female to male I was on testosterone before and the side effects of either singly are not what I'm asking for. I want to know what the side effects of both are on a person my age. I'm sure females on testosterone Cypionate are few and far in between so I just want to know what the side effects of the 2 are for anyone male or female. Whatever information is noted is appreciated
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    Taking atenolol for two years. Taking Prozac for 20 years.
  • I'm starting 7.5 mg remeron tonight , how can i expect to feal in the morning? (1 answer)
    Long period of depression desperate to find something that will work quik and give me some energy.
  • Can nuvigil (vs adderall) be used simultaneously to help wean off 60mg/day of adderall? (1 answer)
    I have been on Adderall 30mg 2x daily for years!! I've had it lowered to 20mg, I've TRIED to go months without it (when not working) however I feel I've built up a tolerance level to the point that it's not as effective as it once was. My personal life has detoured WAY past anything an ADHD medication can possibly help as far as focusing on NEEDED tasks etc. I end up feeling wrapped up in what I'm doing at the moment that my anxiety increases due to all that I haven't been able to accomplish. I take various medications for various reasons, depression, anxiety, bulimia etc., and for the most part the doses have varied based on circumstances and current need at said time of prescription.. MY FAMILY HAS A HISTORY OF HEART DISEASE, And realizing that I'm already on the highest Adderall dosage scares me (and THEN as I think about it, it makes my heart race!). I've also noticed increased muscle spasms as well as extreme and intense pressure on my jaw (TMJ). MY QUESTION IS: does anyone have any experience LOWERING their Adderall dosage AND adding Nuvigil? The research I've done to date gives me impression that it could help balance out the more extreme effects of Adderall (60mg/day) but that the nuvigil would or could potentially help with the EXTREME exhaustion I feel as Adderall wears off. Some days I just crash, some days I sleep fine and others no matter how hard I tryyyy, I just CAN'T fall asleep, therefore making the next day worse! IDEALLY I'D LIKE TO BE MED FREE, right now I need them, but am hoping maybe I can speak with my doctor to lower Adderall and add Nuvigil to help wean me off the amphetamines as well as lower dosage intake. YES, a lot of the anxiety, sleeplessness and depression are related to current circumstances in my life, however, where I am is not where I want to be or where I'm headed.. Life is a journey, and all my meds have become a part of a journey I never thought I'd find myself taking. I don't want life/meds to define me, or create a me I no longer recognize, because scarily enough that seems to be a common pattern. As I overcome each and every daily obstacle, I also don't want to be "hooked" on my meds or needing "more" to wake up/sleep/function.. I'd like to work on finding a solution towards weaning off my meds NOW, and work my way off slowly, primarily the Adderall. I'm hoping by suggesting to my doctor and showing him my research he may agree (IF ITS EVEN A LOGICAL COMBO, CLEARLY IM NOT A DOCTOR) nuvigil could help me. I've already started taking less of my anti depressants, trazadone and xanax without discussing with doc because he is always busy.. My next appt I want to go in fully prepared with a plan and an overall goal to REDUCE my Adderall dose, but overall, I'm clueless!!! I have no idea what other meds other than nuvigil "could" potentially help if at all. I could be entirely wrong, Anyone with any experience using one vs other or both simultaneously, or anyone with constructive input, PLEASE COMMENT/SHARE!!

More questions for: Prozac, Irritability

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    Was taking fluoxetine until recently for a depressive episode (suffered from depression pretty much my whole life). Strange hypnagogic hallucinations and bizarre thoughts, sometimes coupled with feeling faint. Also strong feelings of numbness for the first two weeks or so, headaches and dry mouth. Strangely only on 20mg...This is my second time on fluoxetine and the experience has been totally different (last time it seemed to make me act callously and superficially towards people, and to be generally irresponsible, going out, avoiding work etc.).

    Doctor had now changed me over to sertraline, been on it for 3 days and ok so far apart from minor headaches.
  • A life of depression and fatigue (1 response)
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    do not smoke, avoid horrific or traumatic situations and try to find some enjoyment in life. If you have symptoms like mine seek early treatment put balance in your life. The often heard recommendations - get plenty of sleep, eat properly, learn to relax and avoid bad habits should not be ignored, they are critical to good physical and mental health.
  • Lorazepam nearly killed me during cancer treatment
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  • Yaz was the cause of increasing my pmdd, pms, irritability and depression symptoms
    I had taken Ortho Novum 777 from the age of 18 to 28 stopping in-between pregnancies. I had 3 children between the ages of 21 and 29.

    In my early 30's I decided to stop taking birth control pills simply because I 'thought' it would be a healthier thing to do for my body. I did know that unless I was taking Ortho Novum that my period were not the standard 28 day routine. They were irregular and would be anywhere from 28 to 38 days. The longer the time in between periods the worse the pms symptoms would be. My theory is most likely because of the extended time between when I perceived a period and when I actually got it. It could very well have been psychosomatic but when my period would finally arrive, irritability and bloating would subside within a day or two. It was like a reset button and relief. I was calmer, more rational, even Kiel and motivated.

    In addition to the irregular pattern of my periods when off if birth control pills I also experienced pms twice a month. It would happen mid month when I was ovulating. The ovulation would be uncomfortable, I'd feel bloated again, and the cramps were painful. I'd move from ovulation week of irritability to PMS week of even greater irritability. I'd be waiting and counting down til my period was suppose to happen in anticipation of relief.

    I remember age 32 being significant for some reason. Upon reflecting back over the years while seeking treatment for a solution out of the psyco cycle I remember referring to age 32 as the year that things were never the same as they were in my 20's.

    Mid 30's I had asked my ob/gyn if I could go back on the Ortho Novum 777. I was told that I was too old. This was early 2000's, 2003 or 2004. I was given a different birth control pill that he recommended and I tried that for a while but it wasn't making things better and I don't remember the exact details. I tried bio identical hormones... That wasn't really helpful either, it was more work and a long process that I stuck with for at least a year trying to get the formula right. I finally threw the towel in on that.

    Then a different ob/gyn suggested I try progesterone only. He prescribed a pink round ball of a pill. I was to take it the last 10 days of the month. I tried that for 3 or 4 months, it wasn't making things better... in fact I think it made it worse. Then I went cold turkey again for the better part of a year. At age 37, after not finding a doctor that was helping the situation I decided to find a doctor in AZ. I live full time in CA but had a vacation home in AZ so I thought I'd try that for a change.

    I did find a doctor and she prescribed yaz 24 day. She said it should help me as it has helped many other women. I took the yaz for a little better than a year and psychologically I thought I had a winner! This doctor sounded like she knew my problems and that this was the solution. Alas it was not. I remember feeling the most depressed is ever felt. I didn't think it had anything to do with the yaz, I figured it was just life. When I returned to that doctor after a year I explained my situation. She then recommended that I get an ablation!?! I was never a heavy bleeder and it makes no sense to have that done, but she sold me on the idea that it would help my problem. I realize now she was doing exactly that, selling. I'm sure it was a nice payment from the insurance company.

    None of my issues were solved. I had stopped taking the yaz or any birth control at that point. My period were non existent after boiling my uterus in boiling water, which is what the ablation is. And to this day my period is hardly worth talking about or being prepared for. It's spotting for a couple 3 days at best. With regard to my symptoms, the pms, pmdd, extreme irritability, depression all that stayed the same. I tried Seasonal for about 2 months and that was not good, it seemed to 'amp' the 'hot' - not physically hot but an irritable term I use to describe the upped level my nerves set at.

    I did exercise pretty regularly during all if this. The times I wasn't exercising were over the top as far as pmdd symptoms so that motivates you to get your rear to the gym. On the Yaz 24 day I knew something wasn't right. At day 14 I'd feel the symptoms if ovulation, not imagined but real. I was slightly irritable and had cramps for 2 to 3 days. At day 17, a Wednesday the irritability would ramp up and the depression would start to be present for the next 2 weeks.

    The following Wednesday was day 24, that was the last day of taking the pill. I did get a bit of relief after stopping the pill and 4 days later I resumed taking the next months pack on Sunday. The thing is I wouldn't get my period until Tuesday after I started the new pack? I know that my period should have happened between day 24 and 28 but it never did. It always started on day 31 or 32 and lasted 2 to 3 days. Then the whole cycle begins again with day 14.

    On Yaz 24

    Day 1 Sunday
    Day 3 or 4 Tuesday and my period would start.
    Day 5 or 6 my period ended
    Day 14 - Day 17 ovulation type cramping
    Day 17 irritability started ramping up into PMS, PMDD & Depression
    Symptoms were worse without exercise by at least 40%
    Day 24 Wednesday, last day of Yaz pack for the month
    Day 25 slight mood improvement
    Day 30-31 (same as Day 3/4above) period would start

    The ob/gyn expertise wasn't working, male or female. I went to my regular general practitioner for a check up and had done much research on the type of hormones in the Yaz, Yasmin and many others. I was convinced that I need to move over to Yasmin 21 day. It had a but more estrogen and it was only 21 instead of 24 days so worth a try.

    She asked me when the last time I felt 'normal' with regard to the hormones. I told her that as far as I can recall it was when I was in my 20's when I was taking the Ortho Novum 777. She said why don't we have you start taking that again! I was like, what? I explained I was told I could not take that because of my age and I thought some doctor had told me it had been discontinued years ago anyway. She said no, I can prescribe it to you, it's still available. I was a little excited about that. Maybe... just maybe that would be a solution for relief. My blood pressure is 100/70 always has been low, I don't smoke and I'm 5' 8", 150 pounds. She saw no reason for me not to try it again. We agreed that I would and if it didn't go well we'd try the Yasmin.

    I've been in the Ortho Novum, my package and brand saying Alyacen 7/7/7 for 3 weeks now. Today is Sunday and I stop taking active pills for 7 days now. At day 7 or so I noticed how much easier it was becoming to get out of bed in the morning. I began noticing I had an interest in getting something done. I didn't have a big heavy cloud urging me to just stay in bed. I started feeling alive again.

    The jury is still out and I have ordered a second months supply but I am deeply encouraged. During week 3 I have been crampier than on the yaz but in a very normal feeling way. Like my body is preparing for menstruation. I'm anticipating bleeding heavier than I'm used to, but in a good way. The cramping has been something I definitely notice much much more so but it's manageable. What I also notice is lack...... huge overwhelming lack of that horrible irritability. I'm more sensitive than weeks one and two but it's nothing by comparison. I've been more level headed, more 'normal'. Time will tell if this is my cure for the next 6 or so years but I'm extremely encouraged right now. I literally feel the best I have in years and there is some pretty crapy stressful things going on in my life. But I can handle them-

    Side note, I am a Type A personality. I am under a lot of stress running my own business often. I am a mother of 3 and a very capable woman. Watch out world if I'm back like my 20's nothing will stop me. I'm positive, excited and thankful for this moment.

    It stinks if this is this truly is the solution to my problem, as years of my life and those around me have been effected. But it does no good to look back I'm looking forward with great anticipation!

    Good Luck, I hope this monologue can help someone else just like me and I'll be saving a copy for future female generations of mine.

    God Bless
  • Prescribed drugs side effect (1 response)
    I have been on these 2 drugs (Gabapentin and Baclofen) prescribed by my gp for osteoarthritis and nerve damage in my full back.Now also suffering from the grief of losing my beloved companion Harvey (dog),I was diagnosed with deep depression. I was given fluoxetine and have been taking this for almost 4 weeks (along with the other 2 meds) and today I have a very sore tongue and it has been white for a number of days,i am going to the pharmacy tomorrow to seek some advice as I am not sure I should be taking all these together? As I am on the highest dose of depression tablets with the fluoxetine I feel it is unsafe to take with the other 2 as the baclofen can also be used to treat certain types of depression. But I can not do without either and as I am allergic to codeine I am pretty much stuck.

More reviews for: Prozac, Irritability

Comments from related studies:

  • From this study (2 years ago):

  • I have just had my topamax increased and as it did when I first began, I have this overall feeling of sadness and malaise. Im wondering if its the combination of the medication or just the topamax. It does eventually dissipate, but the feeling sucks! Its as though im never going to be cheerful again. And when I become angry, I become enraged and even irrational! Not me at all.

    Reply

    ed on Oct, 12, 2012:

    I am a 43 year old male. I had a shoulder in January and went to a pain management clinic in June and been taking Topamax since then. I understand how you feel especially when they upped my grams from 50 to 100 a day. My feelings got darker. I am currently trying to get off the medication. I hope all goes well with you.

    Reply

  • From this study (3 years ago):

  • George P on May, 7, 2012:

    I developed torticollis soon after starting abilify. At the same time, I developed pain in my left side. An MRI revealed 4 ruptured disks in my spine, a known cause of torticollis.

    Conclusion: I have no idea (neither, it seems, do the doctors). But I found abilify very effective for its purpose.

    Reply

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