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Review: could Remicade cause Exhaustion, fatigue, lethargy, tiredness, weariness?

Summary: Exhaustion, fatigue, lethargy, tiredness, weariness could be caused by Remicade, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take Methotrexate, and have Rheumatoid arthritis.

We study 85,034 people who have side effects while taking Remicade from FDA and social media. Among them, 1,742 have Exhaustion, fatigue, lethargy, tiredness, weariness. Find out below who they are, when they have Exhaustion, fatigue, lethargy, tiredness, weariness and more.

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Remicade (latest outcomes from 85,433 users) has active ingredients of infliximab. It is often used in crohn's disease.

Exhaustion, fatigue, lethargy, tiredness, weariness

Exhaustion, fatigue, lethargy, tiredness, weariness (feeling of tiredness) (latest reports from 1,536,539 patients) has been reported by people with multiple sclerosis, high blood pressure, depression, rheumatoid arthritis, osteoporosis.

On Apr, 11, 2014: 85,016 people reported to have side effects when taking Remicade. Among them, 1,742 people (2.05%) have Exhaustion, Fatigue, Lethargy, Tiredness, Weariness. They amount to 0.11% of all the 1,535,566 people who have Exhaustion, Fatigue, Lethargy, Tiredness, Weariness on eHealthMe.

Trend of Exhaustion, fatigue, lethargy, tiredness, weariness in Remicade reports

Time on Remicade when people have Exhaustion, fatigue, lethargy, tiredness, weariness * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Exhaustion, fatigue, lethargy, tiredness, weariness67.10%10.28%4.86%7.29%7.66%2.43%0.37%

Gender of people who have Exhaustion, fatigue, lethargy, tiredness, weariness when taking Remicade * :

Exhaustion, fatigue, lethargy, tiredness, weariness65.88%34.12%

Age of people who have Exhaustion, fatigue, lethargy, tiredness, weariness when taking Remicade * :

Exhaustion, fatigue, lethargy, tiredness, weariness0.00%0.56%7.56%5.81%12.61%24.23%19.40%29.83%

Severity of Exhaustion, fatigue, lethargy, tiredness, weariness when taking Remicade ** :

leastmoderateseveremost severe
Exhaustion, fatigue, lethargy, tiredness, weariness0.00%64.29%21.43%14.29%

How people recovered from Exhaustion, fatigue, lethargy, tiredness, weariness ** :

while on the drugafter off the drugnot yet
Exhaustion, fatigue, lethargy, tiredness, weariness0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (1,014 people, 58.21%)
  2. Crohn's disease (984 people, 56.49%)
  3. Pain (270 people, 15.50%)
  4. Colitis ulcerative (248 people, 14.24%)
  5. Psoriatic arthropathy (157 people, 9.01%)

Top co-used drugs for these people * :

  1. Methotrexate (636 people, 36.51%)
  2. Prednisone (596 people, 34.21%)
  3. Imuran (408 people, 23.42%)
  4. Fosamax (405 people, 23.25%)
  5. Folic acid (384 people, 22.04%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

Comments for this study:

Danell (3 years ago):

I have been on Remicade 5 years and the older I get, the more exhaused I get!
Reply the comment

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Remicade, Exhaustion, fatigue, lethargy, tiredness, weariness

You can also:

On eHealthMe, Remicade (infliximab) is often used for crohn's disease. Find out below the conditions Remicade is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Remicade used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (3 months ago):

  • Joint and muscle pain and stiffness started one week before remicade treatment and was gone 8 hours after treatment. 4 weeks later pain and stiffness returned in one day all at once. 3 weeks until next treatment . Mornings are better after some stretching, by the end of the day I can barely walk. Also fatigue, I have trouble sleeping also from the pain.


  • From this study (13 months ago):

  • Had infusion remicade 6 vials like normal every five weeks for last three years. A week ago had infusion and got flu like symptoms. Cough fever and chest pains . Aches all over and joints hurt . Got diareha and feel like no energy still 7 days later. Never had this happen


    lisa on May, 3, 2013:

    I am not a male a 45 year old female


  • From this study (1 year ago):

  • Couldn't walk after second Remicade infusion for Crohn's. Was switched to Humira with same results. Am now bedridden and can no longer work outside the home. Mayo Clinic diagnosed it as drug-induced lupus but blood markers are changing while symptoms are not.



    After the first dose of Infliximab Remicade for HLA B27 + Spondyloarthropathy, ( second is due in May 2012 and I am advised for life long such an expensive treatment with no curability but to restrict the rate of deterioration), my condition is in a fix. My cornea is also affected with total absence of goblet cells suggestive of grade iv squamous metaplasia. However, my Doctor is very good / caring and humanitarian. I took opinion of four leading doctors in India and email advice from USA/UK/Netharland and all confirmed my treatment on correct path. I do not know how to finance Rs.10 Lakhs every year when my income is 50%. of that.
    Jayanta Bandyopadhyay


    bdog4u2 on Dec, 6, 2012:

    I'm a 38 yr old male. I've had crohn's for over 20 years and it sucks.


    Bobbie on Oct, 20, 2012:

    My mother, 53 years old, , diagnosed with ulcerative colitis July of 2011 has passed away from remicade. She had breat cancer and was treated with chemo in 1999 but healthy ever since. There is no other explanation. This drug is scary. If you are thinking of using it see a cardiologist and liver expert before you even think about it. I beg of you. 6 weeks and she was gone...


    Bobby Green on Dec, 6, 2012:

    Been on remicade for over 8 years the worse I got from it was athletes foot. I'm sorry for your mom its a horrible disease and the meds can be worse. I hope we have a cure one day but there's not enough profit in cures I watched remicade go from $2000 a treatment to $7000 its not fair how the sick get preyed upon


    Rainer on Jan, 7, 2013:

    I had exoperienced leg muscle weakness when on Statins of all sorts. Eventually I could not take any of the Statins any longer as they adversly affected me in numerous ways. Stopped Statins and all improved. Started Questran Lite. leg muscles feel like Jelly. May be possibly from this but not sure as yet. Will see Doc to have this confirmed. seems to me when ever I try a medication to help my High Cholesterol / Heart desease issue tthat i am stuffing myself up with considerable side effects affecting my quality of life!!


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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Related study

- Remicade side effects


Related symptom

- Exhaustion, Fatigue, Lethargy, Tiredness, Weariness



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