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Review: could Rituxan cause Mental status changes?

Summary: Mental status changes is found among people who take Rituxan, especially for people who are male, 60+ old, have been taking the drug for < 1 month, also take medication Prednisone, and have Non-hodgkin's lymphoma.

We study 10,200 people who have side effects while taking Rituxan from FDA and social media. Among them, 49 have Mental status changes. Find out below who they are, when they have Mental status changes and more.

You are not alone: join a mobile support group for people who take Rituxan and have Mental status changes >>>

 

 

 

 

Rituxan

Rituxan has active ingredients of rituximab. It is often used in rheumatoid arthritis. (latest outcomes from 10,312 Rituxan users)

Mental status changes

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation) has been reported by people with pain, depression, high blood pressure, multiple myeloma, multiple sclerosis. (latest reports from 14,041 Mental status changes patients)

On Jan, 12, 2015: 10,200 people reported to have side effects when taking Rituxan. Among them, 49 people (0.48%) have Mental Status Changes.

Trend of Mental status changes in Rituxan reports

Time on Rituxan when people have Mental status changes * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Mental status changes58.82%41.18%0.00%0.00%0.00%0.00%0.00%

Gender of people who have Mental status changes when taking Rituxan * :

FemaleMale
Mental status changes49.12%50.88%

Age of people who have Mental status changes when taking Rituxan * :

0-12-910-1920-2930-3940-4950-5960+
Mental status changes0.00%0.00%0.00%0.00%4.26%6.38%8.51%80.85%

Severity of Mental status changes when taking Rituxan ** :

n/a

How people recovered from Mental status changes ** :

n/a

Top conditions involved for these people * :

  1. Non-hodgkin's lymphoma (10 people, 20.41%)
  2. Prostate cancer metastatic (7 people, 14.29%)
  3. Bone disorder (6 people, 12.24%)
  4. Diffuse large b-cell lymphoma (5 people, 10.20%)
  5. Chronic lymphocytic leukaemia (4 people, 8.16%)

Top co-used drugs for these people * :

  1. Prednisone (20 people, 40.82%)
  2. Vincristine (19 people, 38.78%)
  3. Aspirin (16 people, 32.65%)
  4. Lasix (14 people, 28.57%)
  5. Prednisone tab (12 people, 24.49%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Mental Status Changes while taking Rituxan?

You are not alone! Join a mobile support group:
- support group for people who take Rituxan and have Mental Status Changes
- support group for people who take Rituxan
- support group for people who have Mental Status Changes

Drugs in real world that are associated with:

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Can you answer these questions (Ask a question):

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  • How do i at least try to get the psychiatrist doing my follow up assessment to consider the possibility that the mirena iud was the cause of the acute psychosis i experienced?
    I had a Mirena IUD inserted on December 9th. Insertion was fine (but I think I have a pretty high tolerance for pain); but things started going downhill fast. On December 15th I had a blackout drunken episode and in January I had two puffs of a marijuna joint and believe I went briefly Psycotic. I've tried marijuna at most maybe 10 times in my life and aside from once in Amsterdam over 10-years ago (where I likely had more than I should have); I get nothing out of it, don't see what the point is (aside from the possibility maybe I'll realize what all the fuss is about and I might eventually find it relaxing? Thus the ~9 other lifetime attemts.



    I just attributed both of these events to bad behaviour and too much alcohol (blackout drunkeness is not new to me, nor are mental health issues). But things have been very stressful in my life, as owing to my personality and upbrining I am just an anxious person and I have some stress management issues. I like to think this is relatively normal human behavior and not means for locking me up and lecturing me for getting someone to buy me a $10 phone card when the call was worth over $100 and I likely make more money than any of the nurses that are working in the psych ward. But alas I have been labelled bi-polar and someone with mental healt issues so I must be both (a) an excessive spender and financially irresponsible and (b) paranoid and dellusional when I believe I have a well paying job (sorry small rant break...)



    Anyway starting ~early-mid January I started waking up really early. Not a big deal for a few weeks and I am generally a 'bad' sleeper but generally that manifests itself in having a hard time falling asleep, not staying asleep until the morning. I kept waking up earlier and earlier and sleeping less each night, this early waking up (at first 5am, then 4am and in the last few days before I was locked up, more like midnight after ~1 hr of sleep) happened to a much lesser extreme in 2011 with my first real noticable experience with 'elevated states' of mental health; it was terrifying then because I didn't understand if I was going crazy or just making stuff up in my head (to get attention? I don't know, but I don't have the most consience ingrained 3-meals/day eating habbits at the best of times and after long enough with no sleep I no longer feel hungry and I have to consciencely remember that I should eat and I think I've gone days without food in these states. Eventually in 2011 after too long with not enough sleep (and feeling wired, but not generally exhausted) and after consulation with various phone crisis lines I took myself into the ER to get checked out. I came with a binder of notes regarding my mental health history (mostly self observed and not in my medical files anywhere except for the 2008 ER visit and subsequent 'mild depression' diagnosis) and they were great because they listened to me and did not discount everything I was saying just because I have mental health issues. They also were not willing to provide any official diagnosis, even after a number of follow up sessions. I also very much appreciated this because I don't believe there is a whole lot of value to mental health diagnosis aside from necessairy critical assessments and short term action plans; however I don't know (or don't believe owing to my experiences and general 'normailized' cynical outlook on life?)



    I was referred elsewhere for official assessment and subsequently my diagnosis of mild depression and drug regime of antidepressants changed to a bi-polar II dignosis coupled by a doctor who provided 'drug therapy' in the form of lithium and some other mood booster; regular blood tests and monthly lectures wrt if I was aware smoking was an unhealthy activity (yes I have mental health issues, but that does not mean I am stupid nor illeterate; I believe the knowledge that smoking is not healthy has been generally widly accepted as truth long before I was born. i don't actually smoke becuase I think it's the healthiest thing I could ever do for myself!!!). I was either told (or it was just the message I received from the experience?) that I basically had to be on lithium for life, there was no better alternative. This doctor diagnosed me based on the ER medical records; he diagnosed me without even ever talking to me and he never bothered to consider any other options and/or assessments. I am bi-polar II, I am no longer normal or human or really a valuable memeber of society, I need to be drugged so I don't become even more of a problem to society.



    I don't think lithium ever did anything for me, I don't think it did anything to me aside from confusing me and allowing me not to have any confidence in myself and my own ability to manage my health or that the meditation/sun lamp therapy/CBT and other various techniques I started were of any value. I do believe that the antidepressants helped me; but I'm not sure if it was the actual drug or just the placebo effect that gave me hope and allowed me to pull through a 9-month period that made me believe that I really wasn't a valuable memeber of society. But if that's the message I have I don't see why I would stick around in society and waste everybody's time just to be a worthless druggie. I don't see why it's such a horrific thing that I've done, smoking pot ~10 times in my life and using alcohol and ciggarettes to self medicate; these are terrible things that I've done I should stop all of this and become a worthless, lesser version of myself and a prescription-druggie. If it comes in a bottle at the drug store, then it's definitly 'good' drugs?



    Anyway, I was definitly not in a good place mentally but I stayed at home riding it out (using non-mental health help lines to benchmark my physical condition; which I've given some stress with no sleeping and little eating and generally just being stressed out). I've been making decisions on which is the best of all my bad options with a timeframe that kept shrinking (e.g. warm bath is good because it calms me down, but it's bad because heat is problematic and makes the rashes worse which will add at least a little anxiety for a few hours after the bath; wine makes me a little less anxious so I'll drink it when in this state; but I can't afford not to be aware so I can't get drunk so I drink it slowly, maybe I'll have a small buzz on, maybe a little drunk enough to allow myself to go to bed and help me fall asleep - yes, not ideal but how is this better than being on the drugs they kept feeding me in the psych ward that after the first (maybe second?) night that they did help me sleep at night I felt nasuated, confused, dull and stupid? Why is it ok for other people to drink way more than me and have worse hangovers for the next day but I should get the message that I should never drink alcohol but I should always feel worse than horribly hungover so I don't ever cry, snap at someone too loudly again because I might hurt someone's feelings?



    I was planning to go to the ER if that's what my friends and family doctor wanted me to do, owing to my state. I already know I can manage this better and I already know at that point none of the 'professional's' are likely to believe anything I say so I doubt anyone will pay heed to my suggestions that this IUD had any effect? I was admitted to the psych ward but unfortunatly my timing was terrible - it was march break, a lot of the psychiatrists were off skiing so no one could give me any clear indication of when, if ever I would be assessed. I saw the last 30 years flash before my eyes and I can see all of the terrible ways I've been treating myself, I also now believe I was likely sexually assulted by my peditrition (which might explain some of my angst wrt doctors and hospitals and the terror of being locked up in one?) but they told me I was not a good candidate for one on one therapy. I'm posting this annonynously but it's not really something I want to start looking at in detail in a group therapy setting, is that crazy? I'm worried I will be given yet another diagnosis and told I need to take drugs; which will likely make my short term disability claim be denied (as I don't intend to comply with this action plan), and I can't find much on the internet aside from personal experiences individuals have posted wrt the Mirena IUD and psyhcosis so I can't imagine the phychatrist will be interested in listening to my opinion.



    Do I need to go back to school for 8-years and get a PhD in psychatry before anyone will believe I am 'qualified' to assess what I know of myself, given that I am the only one who might have a hope of understanding exactly what has happened in the last 30+ years? Can anyone help me in my fight to be myself rather than a prescription-druggie duller and much less interested version of myself that I know I don't like?
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    Peripheral neuropathy started after my diagnosis and the initiation of the RA meds. My Rheumatologist says it is not associated with the meds BUT I find info on the net that disagrees. I think it is the med(s). I am interested in what experience others have had. Thanks K
  • How does rituxan help pcd patients?
    One neurologist wants to use rituxan to help while the other neurologist says it is too risky and has terrible side effects. Has it helped PCD patients?

More questions for: Rituxan, Mental status changes

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Comments from related studies:

  • From this study (2 months ago):

  • Fell terrible on this drug. Oncologist keeps telling me these symptoms are not from the chemo. I was fine on just the Rituxan. But then I got cancer in my lung lymph nodes. He put me on Treanda. I feel like it's killing me. Wish there was some other drug. Not sure I trust him anymore.

    Reply

    Thomas Norton on Nov, 14, 2014:

    Hope you're doing well. If you are still having trouble with specific chemo drugs, you might want to look into a new oral pill, specifically targeted to the B cells of CLL. Its called Ibrutinib. Very impressive results in trials, and FDA approved this year. I haven't been on it very long, but I've little side effects and am feeling more energy overall. Youtube has some stuff on it also. Good Luck!

    Reply

  • From this study (2 months ago):

  • Have developed a chronic form of myalgia - very painful.

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