Review: could Rituxan cause Rigors?


Rigors is found among people who take Rituxan, especially for people who are male, 60+ old , have been taking the drug for < 1 month, also take medication Benadryl, and have Non-hodgkin's lymphoma . We study 12,688 people who have side effects while taking Rituxan from FDA and social media. Among them, 527 have Rigors. Find out below who they are, when they have Rigors and more.

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Rituxan has active ingredients of rituximab. It is often used in non-hodgkin's lymphoma. (latest outcomes from Rituxan 12,844 users)


Rigors (an episode of shaking or exaggerated shivering) has been reported by people with clostridium difficile colitis, hypotension, abdominal pain, cholestasis, alanine aminotransferase increased (latest reports from 53,914 Rigors patients).

On Aug, 26, 2016

12,688 people reported to have side effects when taking Rituxan.
Among them, 527 people (4.15%) have Rigors

Number of reports submitted per year:

Could Rituxan cause Rigors?

Time on Rituxan when people have Rigors *:

  • < 1 month: 74.78 %
  • 1 - 6 months: 16.52 %
  • 6 - 12 months: 4.35 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 4.35 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Rigors when taking Rituxan *:

  • female: 40.68 %
  • male: 59.32 %

Age of people who have Rigors when taking Rituxan *:

  • 0-1: 0.0 %
  • 2-9: 0.46 %
  • 10-19: 0.0 %
  • 20-29: 2.76 %
  • 30-39: 2.07 %
  • 40-49: 13.56 %
  • 50-59: 20.69 %
  • 60+: 60.46 %

Severity if Rigors when taking Rituxan **:

  • least: 0.0 %
  • moderate: 0.0 %
  • severe: 100 %
  • most severe: 0.0 %

Top conditions involved for these people *:

  • Non-Hodgkin's Lymphoma (74 people)
  • Chronic Lymphocytic Leukaemia (62 people)
  • Lymphoma (40 people)
  • Rheumatoid Arthritis (19 people)
  • B-Cell Lymphoma (16 people)

Top co-used drugs for these people *:

  • Benadryl (52 people)
  • Tylenol (46 people)
  • Prednisone (41 people)
  • Vincristine (37 people)
  • Allopurinol (37 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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