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From FDA reports: Seroquel and Serotonin syndrome

This is a study of Serotonin syndrome among people who take Seroquel. The study analyzes: the time on Seroquel when people have Serotonin syndrome, gender and age of these people, the severity of Serotonin syndrome, how they recovered, and common conditions and drugs used besides Seroquel. In total 63,831 Seroquel users are studied. The study is created by eHealthMe based on reports from FDA and is updated regularly.

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Seroquel

Seroquel has active ingredients of quetiapine fumarate. It is used in bipolar disorder, insomnia, bipolar i disorder, depression, sleep disorder. Commonly reported side effects of Seroquel include diabetes, type 2 diabetes, pancreatitis, diabetic ketoacidosis, insomnia.

Serotonin syndrome

Serotonin syndrome has been reported by people with depression, pain, stress and anxiety, major depression, bipolar disorder.

On Jun, 12, 2013: 63,831 people reported to have side effects when taking Seroquel. Among them, 167 people (0.26%) have Serotonin Syndrome.

Trend of Serotonin syndrome in Seroquel reports

Time on Seroquel when people have Serotonin syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Serotonin syndrome60.87%17.39%10.87%2.17%8.70%0.00%0.00%

Gender of people who have Serotonin syndrome when taking Seroquel * :

FemaleMale
Serotonin syndrome70.56%29.44%

Age of people who have Serotonin syndrome when taking Seroquel * :

0-12-910-1920-2930-3940-4950-5960+
Serotonin syndrome0.00%0.00%3.74%10.16%12.83%32.09%25.67%15.51%

Severity of Serotonin syndrome when taking Seroquel ** :

leastmoderateseveremost severe
Serotonin syndrome0.00%100.00%0.00%0.00%

How people recovered from Serotonin syndrome ** :

n/a

Top conditions involved for these people * :

  1. Depression (84 people, 50.30%)
  2. Insomnia (33 people, 19.76%)
  3. Anxiety (31 people, 18.56%)
  4. Major depression (24 people, 14.37%)
  5. Psychotic disorder (24 people, 14.37%)

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Top co-used drugs for these people * :

  1. Zoloft (49 people, 29.34%)
  2. Lithium carbonate (39 people, 23.35%)
  3. Cymbalta (30 people, 17.96%)
  4. Effexor (29 people, 17.37%)
  5. Paxil (28 people, 16.77%)

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* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

(If the study does not answer your question, use Personalized Q&A)

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Next: check whether serotonin syndrome is from a drug or a condition

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On eHealthMe, Seroquel (quetiapine fumarate) is often used for bipolar disorder. Find out below the conditions Seroquel is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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