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Review: could Sinemet cause Restless leg syndrome?

Summary: Restless leg syndrome is found among people who take Sinemet, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Requip, and have Parkinson's disease.

We study 10,440 people who have side effects while taking Sinemet from FDA and social media. Among them, 72 have Restless leg syndrome. Find out below who they are, when they have Restless leg syndrome and more.

You are not alone: join a mobile support group for people who take Sinemet and have Restless leg syndrome >>>

 

 

 

 

Sinemet

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. (latest outcomes from 11,051 Sinemet users)

Restless leg syndrome

Restless Leg Syndrome (a powerful urge to move your legs) has been reported by people with osteoporosis, depression, pain, high blood pressure, stress and anxiety. (latest reports from 17,452 Restless Leg Syndrome patients)

On Jan, 10, 2015: 10,440 people reported to have side effects when taking Sinemet. Among them, 72 people (0.69%) have Restless Leg Syndrome.

Trend of Restless leg syndrome in Sinemet reports

Time on Sinemet when people have Restless leg syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Restless leg syndrome16.67%0.00%0.00%0.00%66.67%16.67%0.00%

Gender of people who have Restless leg syndrome when taking Sinemet * :

FemaleMale
Restless leg syndrome54.22%45.78%

Age of people who have Restless leg syndrome when taking Sinemet * :

0-12-910-1920-2930-3940-4950-5960+
Restless leg syndrome0.00%0.00%0.00%0.00%1.72%5.17%41.38%51.72%

Severity of Restless leg syndrome when taking Sinemet ** :

leastmoderateseveremost severe
Restless leg syndrome0.00%0.00%0.00%100.00%

How people recovered from Restless leg syndrome ** :

while on the drugafter off the drugnot yet
Restless leg syndrome0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Parkinson's disease (33 people, 45.83%)
  2. Restless legs syndrome (33 people, 45.83%)
  3. Sleep disorder (20 people, 27.78%)
  4. Depression (16 people, 22.22%)
  5. Bipolar disorder (15 people, 20.83%)

Top co-used drugs for these people * :

  1. Requip (41 people, 56.94%)
  2. Seroquel (31 people, 43.06%)
  3. Depakote (20 people, 27.78%)
  4. Lipitor (19 people, 26.39%)
  5. Mirapex (18 people, 25.00%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Restless Leg Syndrome while taking Sinemet?

You are not alone! Join a mobile support group:
- support group for people who take Sinemet and have Restless Leg Syndrome
- support group for people who take Sinemet
- support group for people who have Restless Leg Syndrome

Recent conversations of related support groups:

Drugs in real world that are associated with:

Could your condition cause:

Can you answer these questions (Ask a question):

  • 2 nights i have taken mirtazapine & loratadine and i have had restless legs for 2 hours during the night. i also don't want to put on weight (1 answer)
    I am on a trial taking 10 mg of MIRTAZAPINE for Insomnia, which I have suffered from for many years. I wake every 20-40 minutes all through the night when I do finally go off to sleep. I am also taking LORATADINE to try and help the thick saliva I get in my throat. I have to spit out saliva after drinking. I often feel like I have a lump in my throat of phlegm (but it isn't). My mouth also feel slimy at intervals during the day and night. I have changed my toothpaste to see if that helps. I have only taken these tablets for 2 nights and I already have had restless legs for 2 hours both nights.
  • Can prolia cause parkinson?
    Parkinson appeared to my mother after few time since 1st. Injection of Prolia, 2 years ago had the 2d. These are the patologies she has, and the drugs she takes:
    - Bronchial asthma. - Hiatus hernia. Hashimoto -tiroiditis with hypo- and hyperthyroidism. - Bronchiectasis. - Nasal polyps. - Anxiety. - Neoplasia sigma (2012). I.Q. -- Prolapse uterino- - Cystocele grade II-III (2012). I.Q. - Fibroadenoma.
    Drugs:
    - Tranxilium
    - Sinemet plus
    - Omeprazol
    - Plusvent
    - Calcium sandoz
    - Eutirox
    - Prolia
  • What can i do to help my wife who is on ambien and sometimes has horrible restless leg syndrome?
    She will take her meds like a hour and a half before actually going to sleep. The Zambian that is and sometimes she has uncontrolled restless leg syndrome. She has to move them a certain way and everything. This last time it lasted a hour and a half. I was just wondering if there is anything I could do to belp.?
  • Has abilify affected your ability to make good decisions?
    My husband and I are 73. We had a paid off home and money in the bank until the past 3 years. We have made some terrible decisions and now we are practically penniless. We couldn't understand why we had made such bad decisions and let someone talk us into losing our money. We have also been on Abilify about the same amoount of time and I noticed that the commercials say a side affect can be lack of judgement or something to that effect. Has anyone else had this happen?
  • My sister has a past addiction to morphine. is solonpas addictive?
    I take of my baby sister, because in 2010 she tried to take her life with drugs, alcohol and. Cocaine. She complains of pain in her lower back, due to an injury in 1998, which led to surgery, which led to her addictiction to Morphine. She was diagnosed with Arthritis in her back where she had surgery. She's not allowed anything stronger than an extra strength Tylenol, Alleve and Advil.

    My question would be "Is Solonpas comparable to the OTC pain meds and is it addictive?"

More questions for: Sinemet, Restless leg syndrome

You may be interested at these reviews (Write a review):

  • Restless legs remedy
    After 24 years of restless legs I discovered that the cause was my joints. I have taken glucosamine & chondroitin as well as shark cartilage for 8 weeks and my symptoms have virtually disappeared. I did not see any improvement until after 6 weeks so please stay with this if you decide to give it a try.
  • Pristiq, epilim, sifrol, immovane, valium, mobic
    I started out with mild burnout depression in 2009 and was put on a low dose of Lexapro, which picked me up fantastically. I had been given low (2mg) Valium before for muscle relaxant purposes due to my scoliosis complications. Both these worked well. Then in 2010 I was drugged and raped and almost suffocated by my flatmate. I plummeted after 3 days of numb shock, into the deep dark abyss of major depression, and became fearful about everything. I couldn't enter a shop if there was a queue of men in there for example. Finding myself with complete lack of motivation, neglecting housework, making mistakes constantly at work, I returned to the doctor. He doubled my Lexapro dose. I went back as instructed and was not feeling any better and could not cope with how I felt, so he sent to a psychiatrist. The psychiatrist added Epilim ie pramipexole hyrochloride (low dose) for mood balance, upped the Valium ie daizepam, to 5mg, and prescribed Immovane for my insomnia and terrifying nightmares. Time went on, and I built a tolerance to Lexapro, so he put me on Pristique 200 and Epilim 200. Then I had to have both those doubled (400 each) and I take them twice a day. I have had NO negative side effects at all, and they work excellently for me. As for the restless legs syndrome, that was diagnosed before I was on these medications. The Sifrol had to be increased too as I was told it had to have time to gradually build up in my system. It makes a great difference to my quality of sleep and how my legs feel the next day.
  • Flatulence, lactose intolerance, and clonazapam
    After taking my first dose of Clonazapam, it seemed my lactose intolerance flared up for 24 hours or more. Flatulence all through the period and watery stool in the morning. Does anyone else find their lactose intolerance triggered by the lactose in Clonazapam?
  • How an integrative wellness approach cured me of insomnia, ibs, and more (1 response)
    For 10+ years, I suffered with insomnia and a host of other problems including intestinal distress, headaches, psoriasis, anxiety, cognitive issues, hypothyroid, chronic itching, restless leg, etc. Traditional medicine, aka taking drugs, was not working to heal me. Since childhood, I’ve had IBS, headaches, and upper respiratory problems. Then, in my early twenties, after childbirth, I begin to suffer with panic attacks. I managed to get the panic attacks under control, but the insomnia never went away. I took both Ambien and Clonazepam at different times in my life. When I expressed my concern over taking these meds, my doctor reassured me and told me that some people just have to take sleeping meds for their entire life. I read literature on insomnia and tried most everything – no late night eating, no TV or electronics before bed, sleep in a cool room with complete darkness, meditate, sleep labs, etc. etc. etc. Even with the sleeping meds, I never got restful sleep. Most days, I felt like it was all I could do just to get by. For at least the first half of each day, I felt that I was in dazed stupor until the meds in me would start to wear off. I was first on Clonazepam and then switched to Ambien. When I made the switch, I suffered through withdrawal for about a week. It was horrible -- no sleep, hallucinations, etc. For years, I had silently suffered – my family, friends, and colleagues having no idea to what extent. I felt that mentally, cognitively, and physically I was slowly slipping away. My love for my child and my desire to nurture and provide for him is what kept me going. Without this purpose in my life, I fear that I might have given up somewhere along the way.

    Finally, a few years ago, I went to see an integrative medicine doctor. After years of being in the darkness, I am finally living again. My IM doctor put me on natural supplements, a natural thyroid replacement, and, most importantly, tested me for food allergies/sensitivities. My test results yielded that I could not tolerate wheat, gluten, yeast, and dairy. I took these results seriously and I completely eliminated these things from my diet. After two weeks of adhering to my new diet, I already felt better. In fact, I felt so much better, that, one evening, I decided not to take my Ambien. I have not taken it or any sleep or anxiety medicine since. My doctor was as surprised as I was and did not really anticipate that the diet alone would cure my insomnia. In fact, he had told me that, since I had been taking sleeping meds for so long, eliminating them completely would be a long process that we would have to work through together. Nearly all of the symptoms I listed have disappeared. I continue to take my natural thyroid replacement and the supplements my doctor suggested. I have the occasional migraine and a few patches of psoriasis -- but nothing like the severity I had before. I am 47 now and I am on a journey of healthy transformation. I eat healthy foods, exercise regularly, and truly feel healthy, younger, and physically stronger than I have in 15 and maybe 20 years. Jokingly, my husband used to refer to me as "fragile." Well, not anymore. In fact, he has told me that my body seems like a completely different one. He has had a front-row seat to my transformation and he is as much "in awe" of the changes in me as I am in myself.

    Ten years ago, I was not optimist about my future. Today, I am full of hope, wonder, energy, and excitement. I believe we have the ability to heal ourselves, but we must be diligent in our pursuit of knowledge, persistent and strong in our will to make lifestyle changes, and patient that results will come as long as we are doing all the right things. By the way, giving up foods I had eaten my entire life was not difficult at all once I did it long enough to realize the tremendous benefits of not eating them.
  • Mother recovered significantly from confusion (1 response)
    My very independent, active mother was diagnosed with Parkinson's (long over due, she did not have the common tremor but instead had issues with her gait).

    She was already on Wellbutrin and Prozac because they thought her shuffling was muscle weakness due to inactivity caused by depression. Once properly diagnosed and under the treatment of a neurologist for Parkinson's she was prescribed Sinemet. Her ability to walk increased dramatically however she was extremely confused. She constantly wanted to go home even though she was. She would get angry with us if we tried to convince her otherwise. She confused family members with other people and thought very off the wall situations were occurring with them. The neurologist said she had common symptoms of senile dementia which can accompany Parkinson's patients. Due to a random ordered hearing/vertigo test, we were instructed to take her off of all her medications a week prior to the test. Because the sinemet was so difficult to get her to tolerate due to extreme nausea I did not take her off of it but I took her off everything else. Within four to five days of being off the depression medication which had been combined with the sinemet she had a 360 degree turnaround in her confusion. She was even able to tell me that she knew she was confused but could not reason herself out of it. It was an end to eight months of pure H**. If you have a family suffering confusion and symptoms of senility that is on Sinemet and also taking anti-depression medications, insist that they be weaned of the anti-depressants before you accept the senility diagnosis.

More reviews for: Sinemet, Restless leg syndrome

Comments from related studies:

  • From this study (3 days ago):

  • My restless legs have been an issue since 2002. I have had stages of getting a maximum of 20 minute blocks of sleep then awake for an hour or two all night. Unable to work from 2007 until I started sifrol in 2009. It was working well until about 3 years ago. I am gradually declining again and am scared it will return as severe as before. I had a heart attack in 2006 which I believe was a result of rls. No medical condition was found to have caused my myocardial infarction..I now also feel the restless sensation in my stomach and chest..

    Reply

  • From this study (3 weeks ago):

  • is this caused by the medication?

    Reply

  • From this study (1 month ago):

  • Hyperventilating, severe dyskinesia at same time. Not sure if from under medication or over medication. We not sure where the dyskinesia travels in the body

    Reply

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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