Review: could Suboxone cause Mania?


Mania is found among people who take Suboxone, especially for people who are male, 50-59 old , have been taking the drug for 5 - 10 years, also take medication Klonopin, and have Depression . We study 8,160 people who have side effects while taking Suboxone from FDA and social media. Among them, 42 have Mania. Find out below who they are, when they have Mania and more.

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Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in drug dependence. (latest outcomes from Suboxone 10,334 users)


Mania (a state of abnormally elevated or irritable mood) has been reported by people with drug ineffective, confusional state, drowsiness, insomnia, fatigue (latest reports from 11,319 Mania patients).

On Aug, 18, 2016

8,160 people reported to have side effects when taking Suboxone.
Among them, 42 people (0.51%) have Mania

Number of reports submitted per year:

Could Suboxone cause Mania?

Time on Suboxone when people have Mania *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 20 %
  • 5 - 10 years: 80 %
  • 10+ years: 0.0 %

Gender of people who have Mania when taking Suboxone *:

  • female: 45.24 %
  • male: 54.76 %

Age of people who have Mania when taking Suboxone *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 5.26 %
  • 30-39: 21.05 %
  • 40-49: 36.84 %
  • 50-59: 36.84 %
  • 60+: 0.0 %

Top conditions involved for these people *:

  • Drug Dependence (17 people)
  • Depression (17 people)
  • Anxiety (12 people)
  • Staphylococcal Infection (8 people)
  • Attention Deficit/hyperactivity Disorder (6 people)

Top co-used drugs for these people *:

  • Klonopin (12 people)
  • Subutex (10 people)
  • Pristiq (10 people)
  • Zoloft (9 people)
  • Crystal Methamphetamine (9 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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