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Review: could Sulfasalazine cause Anterior uveitis?

Summary: Anterior uveitis could be caused by Sulfasalazine, especially for people who are female, 40-49 old, also take Methotrexate, and have Rheumatoid arthritis.

We study 11,384 people who have side effects while taking Sulfasalazine from FDA and social media. Among them, 19 have Anterior uveitis. Find out below who they are, when they have Anterior uveitis and more.

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Sulfasalazine (latest outcomes from 11,703 users) has active ingredients of sulfasalazine. It is often used in rheumatoid arthritis.

Anterior uveitis

Anterior uveitis (inflammation of the middle layer of the eye, which includes the iris (coloured part of the eye) and adjacent tissue, known as the ciliary body) (latest reports from 18,562 patients) has been reported by people with ankylosing spondylitis, rheumatoid arthritis, macular degeneration, osteoporosis, multiple sclerosis.

On Apr, 10, 2014: 11,392 people reported to have side effects when taking Sulfasalazine. Among them, 19 people (0.17%) have Anterior Uveitis. They amount to 0.10% of all the 18,479 people who have Anterior Uveitis on eHealthMe.

Trend of Anterior uveitis in Sulfasalazine reports

Time on Sulfasalazine when people have Anterior uveitis * :


Gender of people who have Anterior uveitis when taking Sulfasalazine * :

Anterior uveitis65.00%35.00%

Age of people who have Anterior uveitis when taking Sulfasalazine * :

Anterior uveitis0.00%0.00%0.00%13.33%0.00%60.00%6.67%20.00%

Severity of Anterior uveitis when taking Sulfasalazine ** :


How people recovered from Anterior uveitis ** :


Top conditions involved for these people * :

  1. Rheumatoid arthritis (10 people, 52.63%)
  2. Ankylosing spondylitis (4 people, 21.05%)
  3. Chronic myeloid leukaemia (1 people, 5.26%)
  4. Anaemia (1 people, 5.26%)
  5. Arthritis (1 people, 5.26%)

Top co-used drugs for these people * :

  1. Methotrexate (9 people, 47.37%)
  2. Humira (8 people, 42.11%)
  3. Enbrel (8 people, 42.11%)
  4. Folic acid (5 people, 26.32%)
  5. Arava (5 people, 26.32%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Sulfasalazine, Anterior uveitis

You can also:

On eHealthMe, Sulfasalazine (sulfasalazine) is often used for rheumatoid arthritis. Find out below the conditions Sulfasalazine is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Sulfasalazine used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (3 days ago):

  • Sarcoidosis caused complete heart block. Pacemaker implanted in December 2009 but for the past two years I have had palpitations caused by around 3.7 million ectopic heartbeats per year.

    Sarcoidosis also in lungs and eyes. Extended use of Pred Forte caused development of cataracts, one of which has been removed and I am awaiting the second operation.

    Breathlessness is caused by lack of oxygen entering the bloodstream and my ongoing heart problems

    Rarely able to sleep properly due to pain, sleeping for about 20 minutes at a time when I become so exhausted that the pain can't keep me awake

    Muscle and joint pain have made me weak and clumsy.Pain is felt all over, from head to toes along with muscle cramps and intense burning sensation to skin on lower legs.

    ACE levels fluctuate but average 110 - 150.

    Blood pressure on average is 150 / 78 - no treatment given

    I also take Nefopam Hydrochloride (Acupan) for pain but this drug is not on the list.

    Immobility, fatigue and constant pain have left me very depressed ad harbouring thoughts of suicide. My 15 year old granddaughter has lived with me since the death of my daughter 11 years ago and it is my hope that I will live long enough to see her settled in college and independent after which the only thing I have to look forward to is to end my own suffering.


  • From this study (3 weeks ago):

  • Onset of symptoms of bilateral peripheral neuropathy coincides with onset of other side effects of sulfasalazine. Sulfasalazine dosage level for 4 months was 2 grams daily. Initial neurologic diagnosis was peroneal nerve palsy.
    Undifferentiated spondyloarthropathy is a rare autoimmune disease. Alternate explanations of peripheral neuropathy include but are not limited to autoimmune damage to peroneal nerve.
    Current prednisone dosage level of 7.5 mg daily and current dosage of Sulfasalazine are inadequate to control severe arthritic pain and increase range of motion in 32 joints, including but not limited to spinal facet joints, shoulders, hips, SI joints and sternoclavicular joints. Proposed solution is to increase dosage to 3 grams of Sulfasalazine but not if Sulfasalazine is causing peripheral neuropathy.


  • From this study (2 months ago):

  • morning sweating feeling faint then ok rest of the day


Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

  • Which drug seems more effective for ra pain?
    Severe RA - taking sulfasalazine, but extreme fatigue. Good pain relief with celebrax and cymbalta. Taking prednisone for 6 months, tapering to half a tablet for one month. My concerns are swollen eyelids and hair loss. Anyone know if swelling, especially bad when waking in morning is typical for my ...

  • Does sulfasalazine make you gain weight
    I have steadily gained weight while on this drug has anybody had the same weight gain I do not eat much at all and average activeness nothing different in this since starting the tablets very confused.

  • What systemic treatments work for uveitis?
    I am taking methotrexate injections for uveitis and not having much luck controlling it. The side effects are horrible. I am bedridden for several days. If I am very lucky I have 1, mayby 2 good days a week then it is time for the next injection.

More questions for: Sulfasalazine, Anterior uveitis

More reviews for: Sulfasalazine, Anterior uveitis

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Related study

- Sulfasalazine side effects


Related symptom

- Anterior Uveitis



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