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Review: could Tacrolimus cause Interstitial lung disease?

Summary: Interstitial lung disease is found among people who take Tacrolimus, especially for people who are male, 60+ old, have been taking the drug for < 1 month, also take medication Prednisolone, and have Rheumatoid arthritis.

We study 13,505 people who have side effects while taking Tacrolimus from FDA and social media. Among them, 178 have Interstitial lung disease. Find out below who they are, when they have Interstitial lung disease and more.

You are not alone: join a mobile support group for people who take Tacrolimus and have Interstitial lung disease >>>






Tacrolimus has active ingredients of tacrolimus. It is often used in kidney transplant. (latest outcomes from 13,592 Tacrolimus users)

Interstitial lung disease

Interstitial lung disease has been reported by people with rheumatoid arthritis, high blood pressure, lung cancer - non-small cell, osteoporosis, prostate cancer. (latest reports from 20,667 Interstitial lung disease patients)

On Feb, 4, 2015: 13,504 people reported to have side effects when taking Tacrolimus. Among them, 178 people (1.32%) have Interstitial Lung Disease.

Trend of Interstitial lung disease in Tacrolimus reports

Time on Tacrolimus when people have Interstitial lung disease * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Interstitial lung disease39.33%39.33%8.99%10.11%2.25%0.00%0.00%

Gender of people who have Interstitial lung disease when taking Tacrolimus * :

Interstitial lung disease49.73%50.27%

Age of people who have Interstitial lung disease when taking Tacrolimus * :

Interstitial lung disease0.58%7.60%8.77%8.77%5.26%4.09%12.87%52.05%

Severity of Interstitial lung disease when taking Tacrolimus ** :


How people recovered from Interstitial lung disease ** :


Top conditions involved for these people * :

  1. Rheumatoid arthritis (74 people, 41.57%)
  2. Prophylaxis (34 people, 19.10%)
  3. Bone marrow conditioning regimen (33 people, 18.54%)
  4. Interstitial lung disease (23 people, 12.92%)
  5. Oedema (16 people, 8.99%)

Top co-used drugs for these people * :

  1. Prednisolone (90 people, 50.56%)
  2. Methotrexate (46 people, 25.84%)
  3. Thymoglobulin (37 people, 20.79%)
  4. Fludarabine phosphate (34 people, 19.10%)
  5. Humira (29 people, 16.29%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Interstitial Lung Disease while taking Tacrolimus?

You are not alone! Join a mobile support group:
- support group for people who take Tacrolimus and have Interstitial Lung Disease
- support group for people who take Tacrolimus
- support group for people who have Interstitial Lung Disease

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More questions for: Tacrolimus, Interstitial lung disease

You may be interested at these reviews (Write a review):

  • Thrush while on prograf
    I am a health provider at an emergency room and had a patient come in because of a food bolus and when i examined his oral/pharynx I noticed he had thrush. Patient stated it has been their for a while. Patient also stated he has been having progressive difficulty in swallowing. Pt is a kidney transplant patient and has been worked up for other causes of his thrush (including HIV, as per patient results neg) and everything came back negative. I can only conclude that maybe the prograf which is a immunosupressent can possible be the cause
  • Rituxan mental changes (2 responses)
    Within a month my daughter has had altered mental health symptoms such as confusion 'ADD symptoms' decrease in vision, trouble concentrating, frequent headaches and sharp head pain, forgetfulness, blanks out much more and 'feels off'
    it has now been about 5 months since last rituxan
  • Low platelet blood count
    Kidney transplant had been performed 10 years ago.Mycophenolate mofetil was introduced 5 years ago to replace azathioprine.It has caused various undesirable side effects like severe diarrhea,nausea,nose and gum bleeding and low platelet count.Most of them were reduced as soon as the dose decreased except from the low platelet count which seriously concerns me as it has gone almost down the lowest limit.
  • Suicide attempted at first then sadly completed from prograf
    The mother of my 12 year old son had a very successful career and recently received her 3rd kidney transplant after the previous kidney which lasted over 20 years had eventually succumbed to a chronic kidney disease. She had a very successful career as an RN and then a Nurse Anesthetist. Had a bright future and retirement and college plans etc. for herself and our son. House and vehicles paid off etc.

    She received a transplant which she waited 5 years on dialysis for. Still strong in her career and household and my sons care during those 5 years as well. Once she received her transplant and was prescribed Prograf 1 year ago her life changed dramatically. Confusion, severe depression, loss of focus crying several times a day. She pleaded about every month or so with the doctor to greatly reduce the Prograf or put her back on Immuran which worked well for her the previous 20 plus years. The doctor repeatedly told her there are no mental side effects associated with Prograf and that is was her and her kidney is fine. She went to see a therapist which did not help. She kept pleading the doctor for help including her family and loved ones pleading for her as well explaining how it dramatically changed her mentally. Sadly she began thinking her mind was irrecoverable from the damage from Prograf and started to think she would be a burden to her son and her family. The very ones she has always helped all these years. 6 weeks ago she attempted suicide driving her vehicle into a creek. She was admitted to a psychiatric hospital. A few days later released. She again pleaded with the doctor along with family members explaining how bad it is getting. Also visited a renal doctor locally she knew for her entire career. It was hard to do this as she was embarrassed about her condition but was desperate for help. Unfortunately that doctor to all of our surprise told her to go back to the first doctor and to persist with them. Sadly this was the last straw, she gave up, thinking she was mentally damaged for life despite all of us begging her to hold on til we found a doctor willing to help with something other than Prograf. She committed suicide a few days later. Leaving her son whom she loved and treasured more than anything. She left two suicide notes, one to her son explaining she was only going to hinder his life as she was now incapable of any kind of adult life and especially caring for him. She apologized of course but told him how absolutely special he is and to never ever change. She expressed her pride in him etc. and said she will always be watching him and keep sending signs of this. We believe she does.
  • Suicide by gunshot standing in a cold creek during a prograf episode
    My ex-wife who dearly dearly loved our 12 year old son and did all she could for him every spare minute of every day and had a very very succesful career as a nurse anesthetist until she started taking Prograf and went on leave a month ago after driving her jeep into a creek imagining that a bridge that was taken out (about 7 years ago) was still there which connects to her back yard. She just shot herself in the head standing in a cold creek at the edge of the back yard 2 days ago. She pleaded with the doctors for year, since she got her transplant to go back to Imuran which she did fine on for over 20 years with her first kidney transplant. The doctors repeatedly over the last year kept telling her there are no mental side effects with Prograf and that it was her. Her family all contacted the transplant hospital and the doctors and after a while they wouldnt even return their calls. Now my son is suffering from the sudden loss of his normally very strong loving and successful mother. She even asked to move in with me but I am remarried and my wife had a good argument that she does have a very supportive family there all wanting to help. She did move in with her sister leaving her home in the country that she loves and my son love so much. Beautiful prestine property with two creeks running through it on 25 acres. 6 acre yard. Gorgious property. She loved it and we wanted our son to take it over when he was of age. Suddenly she did this.

More reviews for: Tacrolimus, Interstitial lung disease

Comments from related studies:

  • From this study (2 weeks ago):

  • Liver Transplant around age of three, using Prograf entire life. 16 Years old now.


  • From this study (4 months ago):

  • The nausea is persistent and debilitating as is the fatigue. Nothing relieves the nausea. I was transplanted for esld Chronic Hep B but developed de novo autoimmune hepatitis with a touch of graft v. host disease.

    The emotional troubles became extremely exacerbated post-transplant.

    3 yrs post-transplant, my alkaline phosphatase is 3-4x above avg and my ggt remains at 635. I have developed cirrhosis of the new liver which is just under 3 yrs old due to autoimmune hepatitis. I have been told I will have to be re-transplanted.


  • From this study (4 months ago):

  • Find out safety of Ditropan XL and Trospium for kidney transplant recipients. Interaction of these pharmaceuticals for safety.


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