Review: could Tizanidine Hydrochloride cause Depression?


Depression is found among people who take Tizanidine Hydrochloride, especially for people who are female, 50-59 old , have been taking the drug for 1 - 6 months, also take medication Gabapentin, and have Depression . We study 1,096 people who have side effects while taking Tizanidine hydrochloride from FDA and social media. Among them, 35 have Depression. Find out below who they are, when they have Depression and more.

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Tizanidine Hydrochloride

Tizanidine hydrochloride has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from Tizanidine hydrochloride 1,358 users)


Depression has been reported by people with suicidal ideation, drug ineffective, drug exposure during pregnancy, insomnia, fatigue (latest reports from 245,188 Depression patients).

On Jul, 21, 2016

1,096 people reported to have side effects when taking Tizanidine Hydrochloride.
Among them, 35 people (3.19%) have Depression

Number of reports submitted per year:

Could Tizanidine hydrochloride cause Depression?

Time on Tizanidine Hydrochloride when people have Depression *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 33.33 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 33.33 %
  • 2 - 5 years: 16.67 %
  • 5 - 10 years: 16.67 %
  • 10+ years: 0.0 %

Gender of people who have Depression when taking Tizanidine Hydrochloride *:

  • female: 70.59 %
  • male: 29.41 %

Age of people who have Depression when taking Tizanidine Hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 3.45 %
  • 30-39: 6.9 %
  • 40-49: 31.03 %
  • 50-59: 55.17 %
  • 60+: 3.45 %

Severity if Depression when taking Tizanidine Hydrochloride **:

  • least: 0.0 %
  • moderate: 60 %
  • severe: 40 %
  • most severe: 0.0 %

How people recovered from Depression **:

  • while on drug: 0.0 %
  • after off the drug: 0.0 %
  • not yet: 100 %

Top conditions involved for these people *:

  • Depression (9 people)
  • Multiple Sclerosis (8 people)
  • Pain (6 people)
  • Muscle Spasms (6 people)
  • Migraine (5 people)

Top co-used drugs for these people *:

  • Gabapentin (14 people)
  • Lisinopril (10 people)
  • Baclofen (10 people)
  • Prednisone (9 people)
  • Atenolol (9 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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