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Review: could Tizanidine hydrochloride cause Suicide attempt?

Summary: Suicide attempt is found among people who take Tizanidine hydrochloride, especially for people who are female, 30-39 old, have been taking the drug for < 1 month, also take medication Zolpidem tartrate, and have Muscle spasms. We study 1,214 people who have side effects while taking Tizanidine hydrochloride from FDA and social media. Among them, 26 have Suicide attempt. Find out below who they are, when they have Suicide attempt and more.

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Tizanidine hydrochloride

Tizanidine hydrochloride has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from 1,559 Tizanidine hydrochloride users)

Suicide attempt

Suicide attempt has been reported by people with depression, quit smoking, stress and anxiety, pain, bipolar disorder. (latest reports from 32,157 Suicide attempt patients)

On Apr, 30, 2015: 1,212 people reported to have side effects when taking Tizanidine hydrochloride. Among them, 26 people (2.15%) have Suicide Attempt.

Trend of Suicide attempt in Tizanidine hydrochloride reports

Time on Tizanidine hydrochloride when people have Suicide attempt * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Suicide attempt100.00%0.00%0.00%0.00%0.00%0.00%0.00%

Gender of people who have Suicide attempt when taking Tizanidine hydrochloride * :

Suicide attempt73.08%26.92%

Age of people who have Suicide attempt when taking Tizanidine hydrochloride * :

Suicide attempt0.00%0.00%4.35%0.00%47.83%26.09%21.74%0.00%

Severity of Suicide attempt when taking Tizanidine hydrochloride ** :


How people recovered from Suicide attempt ** :


Top conditions involved for these people * :

  1. Muscle spasms (5 people, 19.23%)
  2. Migraine (3 people, 11.54%)
  3. Anxiety (2 people, 7.69%)
  4. Schizophrenia (2 people, 7.69%)
  5. Anxiety disorder (2 people, 7.69%)

Top co-used drugs for these people * :

  1. Zolpidem tartrate (6 people, 23.08%)
  2. Fluvoxamine maleate (5 people, 19.23%)
  3. Etizolam (5 people, 19.23%)
  4. Singulair (4 people, 15.38%)
  5. Diazepam (4 people, 15.38%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Do you have Suicide Attempt while taking Tizanidine Hydrochloride?


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- support group for people who take Tizanidine hydrochloride and have Suicide Attempt
- support group for people who take Tizanidine hydrochloride
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Comments from related studies:

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  • From this study (2 months ago):

  • I had emergency surgery for small bowel blockage due to lesions from a previous stomach surgery. After I made a complaint of sitting in my own diahrrea for 2 hours, my head nurse, Dan took acception to my complaining and he then,along with a few other young nurses and apprenticing Dr's proceeded to give me morphine which myself, a caregiver and daughter asked them not to give me.that in turn caused NMS!!!


  • From this study (2 months ago):

  • I had been taking Soma and Norco for muscle spasms and pain at adjusted doses for about five years. The treatment worked great, but my PM Doctor no longer prescribes muscle relaxers (strange, as this was prescribed for on going pain management)and referred me to my PCP for the Soma. My PCP indicated that he does not prescribe Soma because Soma is used for long term pain management. In place of the Soma my PCP prescribed Zanaflex @ 4mg tablets 2x per day. This is only my fourth day taking the Zanaflex.

    Day 1- (4mg @ 9am, 4mg @ 4pm) About 45min after taking my first dose I felt a moderate amount of anxiety and my heart was pounding. The symptoms started to decrease within an hour, but the anxiety continued throughout the day. My second dose resulted the same, but the anxiety did not increase.
    Day 2- (same as above, ALL +) I woke up with swollen fingers. My hands did not function fully and I was unable to make a closed fist. At around noon the swelling was less, but my wrists and fingers still felt stiff with decreased range of motion and making a closed fist was uncomfortable.
    Day 3- (same as above, ALL +) The swelling increased with the same results as above. My hands have not returned to normal.
    Day 4- (same as above, ALL +) The swelling is worse. All other symptoms are less.


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