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Review: could Topamax cause Fatigue?

Summary: Fatigue is found among people who take Topamax, especially for people who are female, 40-49 old, have been taking the drug for 1 - 6 months, also take medication Aspirin, and have Migraine. We study 22,617 people who have side effects while taking Topamax from FDA and social media. Among them, 1,305 have Fatigue. Find out below who they are, when they have Fatigue and more.

You are not alone: join a support group for people who take Topamax and have Fatigue >>>

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Topamax has active ingredients of topiramate. It is often used in migraine. (latest outcomes from 24,645 Topamax users)


Fatigue (feeling of tiredness) has been reported by people with multiple sclerosis, high blood pressure, depression, rheumatoid arthritis, osteoporosis. (latest reports from 201,009 Fatigue patients)

On Apr, 30, 2015: 22,606 people reported to have side effects when taking Topamax. Among them, 1,308 people (5.79%) have Fatigue.

Trend of Fatigue in Topamax reports

Time on Topamax when people have Fatigue * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years

Gender of people who have Fatigue when taking Topamax * :


Age of people who have Fatigue when taking Topamax * :


Severity of Fatigue when taking Topamax ** :

leastmoderateseveremost severe

How people recovered from Fatigue ** :

while on the drugafter off the drugnot yet

Top conditions involved for these people * :

  1. Migraine (243 people, 18.58%)
  2. Depression (194 people, 14.83%)
  3. Epilepsy (155 people, 11.85%)
  4. Multiple sclerosis (153 people, 11.70%)
  5. Convulsion (144 people, 11.01%)

Top co-used drugs for these people * :

  1. Aspirin (170 people, 13.00%)
  2. Synthroid (152 people, 11.62%)
  3. Cymbalta (145 people, 11.09%)
  4. Seroquel (142 people, 10.86%)
  5. Xanax (131 people, 10.02%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of topamax and fatigue on

Do you have Fatigue while taking Topamax?


You are not alone! Join a support group on :
- support group for people who take Topamax and have Fatigue
- support group for people who take Topamax
- support group for people who have Fatigue

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More questions for: Topamax, Fatigue

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More reviews for: Topamax, Fatigue

Comments from related studies:

  • From this study (1 month ago):

  • Numbness in face going to partial numbness that feels like a dental shot wearing off. Severe numbness and weakness on both sides, but especially left side. If stand for more than 10 or so minutes, leg starts shaking. Most times when walking, need a wall to guide me. When not completely numb, severe tingling in toes/feet and fingers/hands/wrists spreading up. Feels as if can't completely empty bladder. Difficulty forming words, easy forgetting, hard time remembering. Hand starts to shake when I try to grip things, hold things, writing. Sudden taste change before started topramax; change at end of December. Severe exhaustion. Super tired after 1-1/2 to 2 hours or less dependent on activities. Right arm jumps when at rest. Deep itchy shocking pain; keeps getting worse. Having problems with hands and feet staying warm; feel extremely cold all over even when it's warm. Severe chest pain especially on left side under armpit; feels as if being punched. Vision goes back and fort with blurryness and left eye shakes/twitches occassionally. Night vision is now gone; need some sort of lighting or get severely disoriented. No sense of hunger; have to remember to eat if I remember. Severe pain in fingers, hands, wrists feels as if severely swollen...makes using them extremely difficult. Severe tightness in chest as if a very heavy person sitting on chest; can't catch breath. During showers, feel extremely itchy. afterward, feels like electrical charges over whole body, then severe pain sets in and my head starts getting very foggy and ears ring even more. majority symptoms started March 18 which was over 2 months after being on topramax. These symptoms were not gradual, but hit fast. Two or 3 symptoms a day and worsening. I do see a counselor and a psychiatrist and know this is not anxiety related. Today, Thursday, April 16, saw a neurologist that was inattentive, visit was very short, he was only concerned with the symptoms that led to ER visit and not that symptoms have continued to get worse and that I developed more. Dr did not want to read my symptom diary, but was more concerned about what medications that I was taking. Dr did an eye test and announce that I did not have MS and that I need to seek psychiatric help.


  • From this study (2 months ago):

  • Born epileptic, has pedima and grandma seizures with a sudden on set of what seems to be vertigo. Two weeks of plagued pedi'ma seizures on a daily bases then they subsided leaving the dizzy spells of vertigo in their wake, after 3 weeks of non stop active dizzy spells..was finally told by an ER doctor that I had vertigo


  • From this study (7 months ago):

  • pain in body and head
    foggy mind
    thoughts of suicide


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