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Review: could Topamax cause Lupus-like syndrome?

Summary: Lupus-like syndrome is found among people who take Topamax, especially for people who are female, 20-29 old, have been taking the drug for 1 - 2 years, also take medication Celexa, and have Birth control.

We study 22,595 people who have side effects while taking Topamax from FDA and social media. Among them, 20 have Lupus-like syndrome. Find out below who they are, when they have Lupus-like syndrome and more.

You are not alone: join a mobile support group for people who take Topamax and have Lupus-like syndrome >>>

 

 

 

 

Topamax

Topamax has active ingredients of topiramate. It is often used in migraine. (latest outcomes from 24,610 Topamax users)

Lupus-like syndrome

Lupus-like syndrome (a disease symptom matches with lupus an immune disease) has been reported by people with crohn's disease, rheumatoid arthritis, psoriasis, ulcerative colitis, high blood pressure. (latest reports from 3,089 Lupus-like syndrome patients)

On Feb, 25, 2015: 22,580 people reported to have side effects when taking Topamax. Among them, 20 people (0.09%) have Lupus-like Syndrome.

Trend of Lupus-like syndrome in Topamax reports

Time on Topamax when people have Lupus-like syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Lupus-like syndrome0.00%33.33%0.00%66.67%0.00%0.00%0.00%

Gender of people who have Lupus-like syndrome when taking Topamax * :

FemaleMale
Lupus-like syndrome100.00%0.00%

Age of people who have Lupus-like syndrome when taking Topamax * :

0-12-910-1920-2930-3940-4950-5960+
Lupus-like syndrome0.00%0.00%6.25%43.75%12.50%18.75%18.75%0.00%

Severity of Lupus-like syndrome when taking Topamax ** :

leastmoderateseveremost severe
Lupus-like syndrome0.00%0.00%100.00%0.00%

How people recovered from Lupus-like syndrome ** :

while on the drugafter off the drugnot yet
Lupus-like syndrome0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Contraception (7 people, 35.00%)
  2. Irritable bowel syndrome (5 people, 25.00%)
  3. Rash erythematous (4 people, 20.00%)
  4. Migraine prophylaxis (3 people, 15.00%)
  5. Migraine (3 people, 15.00%)

Top co-used drugs for these people * :

  1. Celexa (7 people, 35.00%)
  2. Micronor (7 people, 35.00%)
  3. Bentyl (6 people, 30.00%)
  4. Cortisone cream (4 people, 20.00%)
  5. Neurontin (2 people, 10.00%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

Comments for this study:

Jmason (5 months ago):

Hello, I am a 32 year old Female. About 4 years ago I was put on Topamax 50mg daily for migraines. Two months later dose increased to two 50mg tabs daily. I started losing weight like crazy! Within the first year of being on Topamax I lost total of 35lbs. I even called my PCP at one point bc I was afraid to lose anymore weight. He said it would plateau at some point and not to worry. Which it did. It was around the 2nd year of being on the topamax I started noticing little symptoms that were abnormal for me... Poor circulation, getting more forgetful, my speech would get jumbled at times. My 3rd year I was getting aches and pains all over in spurts "flare ups" my finger tips were turning white and going numb/my ring finger especially. I was then referred to a Rheumatoligist and diagnosed with Raynauds Syndrome. This was unfortunately after a long series of unneeded testing by several specialists. I was having pain in my chest. Saw several cardiologists. Numerous tests done. Found enlarged right side of my heart but nothing "serious" pain in my chest continued so MRIs, chest XRaYs, etc... Finally when I was sent to the Rheumatologist: pleurisy!
Boat load of lab work. Showing I do have Lupus. SLE.
Currently on Plaquenil. Cellcept. Prednisone. HCTZ. Celexa. Topamax. Vit D 50,000 Units. Vit B12injections. And I'm STILL tired!!! I don't know how that's possible! I'm in constant "brain fog" stiff neck all the time. Achy pain in joints.. So frustrating!
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How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of topamax and lupus-like syndrome on

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Drugs in real world that are associated with:

Could your condition cause:

Can you answer these questions (Ask a question):

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    I never really recovered... The obstruction returned after 2 days and a portion of necrotic bowel was removed, then further fever and cellulitis then MRSA and deaths door.... Isolation in high dependency (intensive care) wound break down, ventilated and all related issues that come with that - chest infection, pneumonia, bed sores. Total time in hospital 8 months. Negative pressure dressing on laparotomy wound, colostomy, picc, 4 rounds of vancomycin, minor flirt with heart failure (just water related) an eventually everything healed. Had a large incisional hernia to repair and some corrective work to the horrific scarring but then the neuropathy started plus problems eating, spewing up after any solid food, more than a few forks, diarrhoea and sickness or constipation nausea and pain driving me mad, tried all manner of drugs, nerve blocks, physio, floating tank, acupuncture, opiates, non opiates, spinal cord stimulation, an now a consultant just had a 'eureka' moment and said were you treated with vancomycin when you had MRSA? If so I'm pretty sure you have chronic intestinal pseudo obstruction and is 90% sure but wants to take a muscle biopsy to be certain. I've had so much surgery and bad news in the last 10yrs I'm terrified of germs, hospital acquired bugs and anaesthetics, is there any other way? Or can I have this test done awake - conscious sedation? I had it before during spinal cord surgery so I know what's involved and it's better than GA as I know what's going on, who is doing what to me etc...
    Does anyone with a medical background know about this ailment/disease? Does it sound feasible that MRSA or it's treatment could have caused this? I was surgically debrided up to every other day when the vac pac/negative pressure machine and dressings were changed and the doctors told me I lost a great deal of tissue and had a lot of nerve damage due to the infection.
    Any patient perspectives on this illness would also be very much valued in helping me make a decision, moving forward. If all this is going to accomplish is to attach a label to the pain but not actually change anything, after fighting it for 10yrs now, avoiding hospital as much as I can, I really can't see the point of exploratory surgerys and biopsys now when it is known that I have this propensity towards adhesions and a new wound means a potentially new adhesion growth site.
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    Beat Wishes.

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More reviews for: Topamax, Lupus-like syndrome

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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