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Review: could Topamax cause Lupus-like syndrome?

We study 22,500 people who have side effects while taking Topamax from FDA and social media. Among them, 20 have Lupus-like syndrome. Find out below who they are, when they have Lupus-like syndrome and more.

Get connected: join a mobile support group for people who take Topamax and have Lupus-like syndrome >>>


Topamax (latest outcomes from 24,533 users) has active ingredients of topiramate. It is often used in migraine.

Lupus-like syndrome

Lupus-like syndrome (a disease symptom matches with lupus an immune disease) (latest reports from 10,901 patients) has been reported by people with crohn's disease, rheumatoid arthritis, psoriasis, ulcerative colitis, high blood pressure.

On Sep, 15, 2014: 22,500 people reported to have side effects when taking Topamax. Among them, 20 people (0.09%) have Lupus-like Syndrome.

Trend of Lupus-like syndrome in Topamax reports

Time on Topamax when people have Lupus-like syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Lupus-like syndrome0.00%33.33%0.00%66.67%0.00%0.00%0.00%

Gender of people who have Lupus-like syndrome when taking Topamax * :

Lupus-like syndrome100.00%0.00%

Age of people who have Lupus-like syndrome when taking Topamax * :

Lupus-like syndrome0.00%0.00%6.25%43.75%12.50%18.75%18.75%0.00%

Severity of Lupus-like syndrome when taking Topamax ** :

leastmoderateseveremost severe
Lupus-like syndrome0.00%0.00%100.00%0.00%

How people recovered from Lupus-like syndrome ** :

while on the drugafter off the drugnot yet
Lupus-like syndrome0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Contraception (7 people, 35.00%)
  2. Irritable bowel syndrome (5 people, 25.00%)
  3. Rash erythematous (4 people, 20.00%)
  4. Migraine prophylaxis (3 people, 15.00%)
  5. Migraine (3 people, 15.00%)

Top co-used drugs for these people * :

  1. Celexa (7 people, 35.00%)
  2. Micronor (7 people, 35.00%)
  3. Bentyl (6 people, 30.00%)
  4. Cortisone cream (4 people, 20.00%)
  5. Neurontin (2 people, 10.00%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

Comments for this study:

Jmason (1 week ago):

Hello, I am a 32 year old Female. About 4 years ago I was put on Topamax 50mg daily for migraines. Two months later dose increased to two 50mg tabs daily. I started losing weight like crazy! Within the first year of being on Topamax I lost total of 35lbs. I even called my PCP at one point bc I was afraid to lose anymore weight. He said it would plateau at some point and not to worry. Which it did. It was around the 2nd year of being on the topamax I started noticing little symptoms that were abnormal for me... Poor circulation, getting more forgetful, my speech would get jumbled at times. My 3rd year I was getting aches and pains all over in spurts "flare ups" my finger tips were turning white and going numb/my ring finger especially. I was then referred to a Rheumatoligist and diagnosed with Raynauds Syndrome. This was unfortunately after a long series of unneeded testing by several specialists. I was having pain in my chest. Saw several cardiologists. Numerous tests done. Found enlarged right side of my heart but nothing "serious" pain in my chest continued so MRIs, chest XRaYs, etc... Finally when I was sent to the Rheumatologist: pleurisy!
Boat load of lab work. Showing I do have Lupus. SLE.
Currently on Plaquenil. Cellcept. Prednisone. HCTZ. Celexa. Topamax. Vit D 50,000 Units. Vit B12injections. And I'm STILL tired!!! I don't know how that's possible! I'm in constant "brain fog" stiff neck all the time. Achy pain in joints.. So frustrating!
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Do you have Lupus-like Syndrome while taking Topamax?

Get connected! Join a mobile support group:
- group for people who take Topamax and have Lupus-like Syndrome
- group for people who take Topamax
- group for people who have Lupus-like Syndrome

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More reviews for: Topamax, Lupus-like syndrome

On eHealthMe, Topamax (topiramate) is often used for migraine. Find out below the conditions Topamax is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Topamax used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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